Gama Orizanol, Gamma-Oryzanol, Gamma-OZ, Oryzanol.


Overview Information

Gamma oryzanol is a substance that is taken out of rice bran oil. It is also found in wheat bran and some fruits and vegetables. People use it as medicine.

Gamma oryzanol is used for high cholesterol, symptoms of menopause, and many other conditions, but there is no good scientific evidence to support most of these uses.

How does it work?

Gamma oryzanol might reduce cholesterol levels by reducing absorption of cholesterol from foods.

Gamma oryzanol is also often promoted for treating menopause, but it is unclear how it would work for this use. Some researchers suspect it might be helpful due to effects on luteinizing hormone (LH). However, this effect has not been shown in people.

Some people use gamma oryzanol for increasing testosterone and growth hormone levels. However, gamma oryzanol appears to have no effect on these hormone levels. In fact, animal studies suggest that gamma oryzanol might even reduce testosterone production.


Uses & Effectiveness?

Possibly Effective for

  • Abnormal levels of cholesterol or blood fats (dyslipidemia). Most research shows that taking gamma oryzanol by mouth decreases total cholesterol, "bad" low-density lipoprotein (LDL) cholesterol, and blood fats called triglycerides in people with high cholesterol. The effects of gamma oryzanol on "good" high-density lipoprotein (HDL) cholesterol are mixed. Rice bran oil with gamma oryzanol also lowers LDL cholesterol. But it is unclear if the amount of gamma oryzanol in rice bran oil makes an impact on lowering LDL cholesterol.

Insufficient Evidence for

  • Athletic performance. Taking gamma oryzanol while participating in resistance training doesn't seem to improve muscular strength or jump power in well-trained male athletes. But it may improve muscular strength when used by untrained men.
  • Eczema (atopic dermatitis). Early research shows that bathing in bathwater containing a small amount of gamma oryzanol each day for up to 6 months improves eczema in children.
  • High blood pressure.
  • Menopause symptoms.
  • Other conditions.
More evidence is needed to rate the effectiveness of gamma oryzanol for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Gamma oryzanol is POSSIBLY SAFE for most adults when taken by mouth.

When applied to the skin: Gamma oryzanol is POSSIBLY SAFE for most adults when applied to the skin.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking gamma oryzanol if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Under-active thyroid (hypothyroidism): Gamma oryzanol might lower thyroid function. Don't use gamma oryzanol if you have thyroid problems.



We currently have no information for GAMMA ORYZANOL Interactions.



The following doses have been studied in scientific research:


  • For lowering abnormal levels of cholesterol or blood fats (dyslipidemia): the usual dose of gamma oryzanol is 300 mg once daily or in three divided doses daily. In one study, rice brain oil 30 mL containing 4000, 8000, and 11000 ppm gamma oryzanol was used.

View References


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