GAMMA-ORYZANOL: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Gamma-oryzanol is group of chemicals found in rice bran oil. It is also found in wheat bran and some fruits and vegetables.

Gamma-oryzanol isn't absorbed well in the gut. Because of this, it might reduce cholesterol levels by reducing how much cholesterol is absorbed from foods.

People use gamma-oryzanol for high cholesterol, symptoms of menopause, athletic performance, eczema, high blood pressure, and many other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness ?

Possibly Effective for

Abnormal levels of cholesterol or blood fats (dyslipidemia). Taking gamma-oryzanol by mouth might decrease total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and blood fats called triglycerides in people with high cholesterol.

There is interest in using gamma-oryzanol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

Special Precautions and Warnings

When taken by mouth: Gamma-oryzanol is possibly safe when used in doses up to 300 mg daily. It seems to be well-tolerated.

When applied to the skin: Gamma-oryzanol is possibly safe when used appropriately. Pregnancy and breast-feeding: There isn't enough reliable information to know if gamma-oryzanol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Thyroid conditions: Gamma-oryzanol might change thyroid function. Speak with a healthcare provider before using gamma-oryzanol if you have a thyroid condition.

Interactions ?

We currently have no information for GAMMA-ORYZANOL overview.

Dosing

Gamma-oryzanol has most often been used by adults in doses of 100-300 mg by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

REFERENCES:

Accinni, R., Rosina, M., Bamonti, F., Della, Noce C., Tonini, A., Bernacchi, F., Campolo, J., Caruso, R., Novembrino, C., Ghersi, L., Lonati, S., Grossi, S., Ippolito, S., Lorenzano, E., Ciani, A., and Gorini, M. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects. Nutr Metab Cardiovasc.Dis. 2006;16(2):121-127. View abstract.

Arai, T. [Effect of gamma-oryzanol on indefinite complaints in the gastrointestinal symptoms in patients with chronic gastritis--studies on the endocrinological environment (author's transl)]. Horumon To Rinsho 1982;30(3):271-279. View abstract.

Berger, A., Rein, D., Schafer, A., Monnard, I., Gremaud, G., Lambelet, P., and Bertoli, C. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men*. Eur J Nutr 2005;44(3):163-173. View abstract.

Chen, C. W. and Cheng, H. H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006;136(6):1472-1476. View abstract.

Cicero, A. F. and Gaddi, A. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother Res 2001;15(4):277-289. View abstract.

Fujiwaki, T. and Furusho, K. An open study of gamm-oryzanol as a bath product for children with atopic dermatitis. Acta Paediatrica Hungarica 1993;33(3-4):287-298.

Hayakawa, R. Clinical evaluation of FC-9201 cream containing 1.0% gamma-oryzanol. Skin Research 1993;35(1):131-154.

Hayakawa, R., Suzuki, M., and Ogino, Y. Clinical evaluation of gamma-oryzanol on skin diseases with dry skin. Acata Dermatologica 1994;89(1):115-119.

Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., and Ito, N. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene. Cancer Lett. 8-15-1994;83(1-2):149-156. View abstract.

Ichimaru, Y., Moriyama, M., Ichimaru, M., and Gomita, Y. [Effects of gamma-oryzanol on gastric lesions and small intestinal propulsive activity in mice]. Nippon Yakurigaku Zasshi 1984;84(6):537-542. View abstract.

Itaya, K., Kitonaga, J., and Ishikawa, M. [Studies of gamma-oryzanol. (2) The antiulcerogenic action]. Nippon Yakurigaku Zasshi 1976;72(8):1001-1011. View abstract.

Juliano, C., Cossu, M., Alamanni, M. C., and Piu, L. Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm 8-11-2005;299(1-2):146-154. View abstract.

Kitazume, H., Ageishi, Y., Iwama, T., Kubo, I., and Suzuki, A. [Ticlopidine may prevent subtotal or total occlusion of dilated lesions after percutaneous coronary angioplasty]. J Cardiol 1993;23(2):149-155. View abstract.

Lichtenstein, A. H., Ausman, L. M., Carrasco, W., Gualtieri, L. J., Jenner, J. L., Ordovas, J. M., Nicolosi, R. J., Goldin, B. R., and Schaefer, E. J. Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans. Arterioscler.Thromb. 1994;14(4):549-556. View abstract.

Most, M. M., Tulley, R., Morales, S., and Lefevre, M. Rice bran oil, not fiber, lowers cholesterol in humans. Am J Clin Nutr 2005;81(1):64-68. View abstract.

Ng, S. S. and Figg, W. D. Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice. Anticancer Res 2003;23(5A):3585-3590. View abstract.

Parrado, J., Miramontes, E., Jover, M., Marquez, J. C., Angeles, Mejias M., Collantes, De Teran, Absi, E., and Bautista, J. Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran. Eur J Nutr 2003;42(6):307-314. View abstract.

Rosenbloom, C., Millard-Stafford, M., and Lathrop, J. Contemporary ergogenic aids used by strength/power athletes. J Am Diet Assoc 1992;92(10):1264-1266. View abstract.

Rukmini, C. and Raghuram, T. C. Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. J Am Coll Nutr 1991;10(6):593-601. View abstract.

Sugano, M. and Tsuji, E. Rice bran oil and cholesterol metabolism. J Nutr 1997;127(3):521S-524S. View abstract.

Suh, M. H., Yoo, S. H., Chang, P. S., and Lee, H. G. Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats. J Agric.Food Chem 12-14-2005;53(25):9747-9750. View abstract.

Suwa, M., Inoue, H., Adachi, Y., Nagamine, Y., and Yamamoto, T. Treatment of hyperlipidemia with probucol, gamma-oryzanol or their combination. Medical Journal of Kinki University 1988;13(4 Suppl.):83-85.

Tezuka, T. The clinical effects of bathquina for dry, scaly skin of atopic dermatitis patients. Skin Research 1992;34(5):624-638.

Xu, Z. and Godber, J. S. Purification and identification of components of gamma-oryzanol in rice bran Oil. J Agric.Food Chem 1999;47(7):2724-2728. View abstract.

Xu, Z., Hua, N., and Godber, J. S. Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. J Agric.Food Chem 2001;49(4):2077-2081. View abstract.

Yoshino, G., Kazumi, T., Amano., M., Tateiwa., M., Yamasaki, T., Takashima, S., Iwai, M., Hatanaka, H., and Baba, S. Effects of gamma-oryzanol and probucol on hyperlipidemia. Current Therapeutic Research, Clinical & Experimental 1989;45(6):975-982.

Yoshino, G., Kazumi, T., Amano., M., Tateiwa., M., Yamasaki, T., Takashima, S., Iwai, M., Hatanaka, H., and Baba, S. Effects of gamma-oryzanol on hyperlipidemic subjects. Current Therapeutic Research, Clinical & Experimental 1989;45(4):543-552.

Ahn J, Son HJ, Seo HD, et al. ?-Oryzanol improves exercise endurance and muscle strength by upregulating PPARd and ERR? activity in aged mice. Mol Nutr Food Res. 2021 Jul;65(14):e2000652. View abstract.

Bumrungpert A, Chongsuwat R, Phosat C, Butacnum A. Rice Bran Oil Containing Gamma-Oryzanol Improves Lipid Profiles and Antioxidant Status in Hyperlipidemic Subjects: A Randomized Double-Blind Controlled Trial. J Altern Complement Med. 2019;25(3):353-358. View abstract.

Devarajan S, Singh R, Chatterjee B, Zhang B, Ali A. A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients. J Clin Lipidol. 2016;10(2):339-49. View abstract.

Eslami S, Esa NM, Marandi SM, Ghasemi G, Eslami S. Effects of gamma oryzanol supplementation on anthropometric measurements & muscular strength in healthy males following chronic resistance training. Indian J Med Res. 2014;139(6):857-63. View abstract.

Fry AC, et al. The effects of gamma-oryzanol supplementation during resistance exercise training. Int J Sport Nutr 1997;7:318-29. View abstract.

Grunewald KK, Bailey RS. Commercially marketed supplements for bodybuilding athletes. Sports Med 1993;15:90-103. View abstract.

Ishihara M, Ito Y, Nakakita T, et al. [Clinical effect of gamma-oryzanol on climacteric disturbance- on serum lipid peroxides]. Nippon Sanka Fujinka Gakkai Zasshi 1982;34:243-51. View abstract.

Mäkynen K, Chitchumroonchokchai C, Adisakwattana S, Failla M, Ariyapitipun T. Effect of gamma-oryzanol on the bioaccessibility and synthesis of cholesterol. Eur Rev Med Pharmacol Sci. 2012;16(1):49-56. View abstract.

Minatel IO, Lee YM, Yoon H, et al. Antiadipogenic Activity of y-Oryzanol and Its Stability in Pigmented Rice. J Med Food. 2016;19(7):710-5. View abstract.

Sasaki J, Takada Y, Handa K, et al. Effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin Ther 1990;12:263-8. View abstract.

Seetharamaiah GS, Chandrasekhara N. Effect of oryzanol on cholesterol absorption and biliary and fecal bile acids in rats. Indian J Med Res 1990;92:471-5. View abstract.

Shimomura Y, Kobayashi I, Maruto S, et al. Effect of gamma-oryzanol on serum TSH concentrations in primary hypothyroidism. Endocrinol Jpn 1980;27:83-6. View abstract.

Sugano M, Koba K, Tsuji E. Health benefits of rice bran oil. Anticancer Res 1999;19:3651-7. View abstract.

Sugano M, Tsuji E. Rice bran oil and human health. Biomed Environ Sci 1996;9:242-6. View abstract.

Wang L, Lin Q, Yang T, et al. Oryzanol Modifies High Fat Diet-Induced Obesity, Liver Gene Expression Profile, and Inflammation Response in Mice. J Agric Food Chem. 2017;65(38):8374-8385. View abstract.

Wang O, Liu J, Cheng Q, et al. Effects of ferulic acid and ?-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats. PLoS One. 2015;10(2):e0118135. View abstract.

Wheeler KB, Garleb KA. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects. Int J Sport Nutr 1991;1:170-7. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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