Overview
Androstenedione is used to increase the production of the hormone testosterone to enhance athletic performance, build muscle, reduce body fat, increase energy, keep red blood cells healthy, and increase sexual desire and performance.
Androstenedione gained popularity as the supplement used by the baseball homerun hitter Mark McGwire and other professional sports players. In January 2005 legislation went into effect in the United States called the Anabolic Steroid Control Act of 2004. This reclassified androstenedione from a dietary supplement to an anabolic steroid, which is a schedule III controlled substance.
Androstenedione is considered a banned substance by the National Collegiate Athletic Association (NCAA).
How does it work ?
Uses & Effectiveness
Likely InEffective for
- Enhancing athletic performance. Taking androstenedione by mouth in doses of 100-300 mg per day does not significantly increase muscle strength, muscle size, or lean body mass when used for 2-3 months in connection with weight training.
Insufficient Evidence for
- Increasing energy.
- Red blood cell health.
- Increasing sexual desire and function.
- Other conditions.
Side Effects
There is some concern that the strength and purity of androstenedione products may not match the product labeling.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Androstenedione is LIKELY UNSAFE to use during pregnancy. It might bring on labor and cause a miscarriage.Not enough is known about the safety of using androstenedione during breast-feeding. Stay on the safe side and avoid use.
Children: In children, androstenedione is LIKELY UNSAFE as it might stop bone growth and lead to shorter adult height. It might also cause early onset of puberty.
Depression: There is concern that androstenedione supplements might make depression worse in women. This is because some women with severe major depression have naturally high levels of androstenedione, so some people think there may be a connection. However, it is not known if taking androstenedione supplements causes depression.
Hormone-sensitive cancers and conditions: Androstenedione is the steroid hormone used by the body to make testosterone and estrogen. Taking androstenedione seems to increase estrogen levels. Men and women with hormone sensitive conditions should avoid androstenedione. Some of these conditions include breast, uterine, ovarian, and prostate cancer; endometriosis; and uterine fibroids.
Liver disease: There is some concern that androstenedione might harm the liver. So far, no such cases have been reported, but steroids similar to androstenedione have been connected to liver problems. Don't take androstenedione if you have any type of liver disease. Even if you don't have liver disease, it's best to get liver function tests if you take androstenedione.
Polycystic ovary syndrome (PCOS): There is concern that androstenedione supplements might worsen symptoms of PCOS. This is because women with PCOS have naturally high levels of androstenedione. But it is not known if taking androstenedione supplements actually worsens symptoms of PCOS.
Prostate cancer: There is some concern that androstenedione might increase the chances of developing prostate cancer. Developing research suggests that androstenedione can encourage prostate tumor cell growth. Don't use androstenedione if you have prostate cancer.
Special Precautions and Warnings
There is some concern that the strength and purity of androstenedione products may not match the product labeling.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Androstenedione is LIKELY UNSAFE to use during pregnancy. It might bring on labor and cause a miscarriage.Not enough is known about the safety of using androstenedione during breast-feeding. Stay on the safe side and avoid use.
Children: In children, androstenedione is LIKELY UNSAFE as it might stop bone growth and lead to shorter adult height. It might also cause early onset of puberty.
Depression: There is concern that androstenedione supplements might make depression worse in women. This is because some women with severe major depression have naturally high levels of androstenedione, so some people think there may be a connection. However, it is not known if taking androstenedione supplements causes depression.
Hormone-sensitive cancers and conditions: Androstenedione is the steroid hormone used by the body to make testosterone and estrogen. Taking androstenedione seems to increase estrogen levels. Men and women with hormone sensitive conditions should avoid androstenedione. Some of these conditions include breast, uterine, ovarian, and prostate cancer; endometriosis; and uterine fibroids.
Liver disease: There is some concern that androstenedione might harm the liver. So far, no such cases have been reported, but steroids similar to androstenedione have been connected to liver problems. Don't take androstenedione if you have any type of liver disease. Even if you don't have liver disease, it's best to get liver function tests if you take androstenedione.
Polycystic ovary syndrome (PCOS): There is concern that androstenedione supplements might worsen symptoms of PCOS. This is because women with PCOS have naturally high levels of androstenedione. But it is not known if taking androstenedione supplements actually worsens symptoms of PCOS.
Prostate cancer: There is some concern that androstenedione might increase the chances of developing prostate cancer. Developing research suggests that androstenedione can encourage prostate tumor cell growth. Don't use androstenedione if you have prostate cancer.
Interactions
Estrogens interacts with ANDROSTENEDIONE
Androstenedione seems to increase estrogen levels in the body. Taking androstenedione along with estrogen pills might cause too much estrogen in the body.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Moderate Interaction
Be cautious with this combination
Dosing
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.