Bovine Colostrum, Bovine Immunoglobulin, Bovine Lacteal Compounds, Calostro, Colostrum Bovin, Colostrum Bovin Hyperimmune, Colostrum de Chèvre, Colostrum de Lait de Vache, Cow Milk Colostrum, Goat Colostrum, Hyperimmune Bovine Colostrum, Immunoglobuline Bovine, Lait Colostral, Protogala.<br/><br/>
Overview InformationBovine colostrum is a milky fluid that comes from the breasts of cows the first few days after giving birth, before true milk appears. It contains proteins, carbohydrates, fats, vitamins, minerals, and specific kinds of proteins called antibodies that fight disease-causing agents such as bacteria and viruses. Antibody levels in bovine colostrum can be 100 times higher than levels in regular cow's milk.
People originally got interested in bovine colostrum because of the high antibody levels. They thought that the antibodies might prevent infections in people.
Some athletes take bovine colostrum by mouth to burn fat, build lean muscle, increase stamina and vitality, and improve athletic performance. Bovine colostrum is not on the banned drug list of the International Olympic Committee.
Bovine colostrum is also taken by mouth for boosting the immune system, healing injuries, repairing nervous system damage, improving mood and sense of well-being, slowing and reversing aging, and as an agent for killing bacteria and fungus.
Bovine colostrum is used in the rectum for inflammation of the colon (colitis). It is used in the vagina for HPV (human papilloma virus) and for thinning of the vaginal wall in women after menopause.
Bovine colostrum is applied in the mouth to reduce dental plaque and to treat mouth inflammation associated with diseases like oral lichen planus and Sjogren's syndrome. In the eyes, bovine colostrum is applied for dry eyes.
Researchers have created a special type of bovine colostrum called "hyperimmune bovine colostrum." This special colostrum is produced by cows that have received vaccinations against specific disease-causing organisms. The vaccinations cause the cows to develop antibodies to fight those specific organisms. The antibodies pass into the colostrum. Hyperimmune bovine colostrum has been used in clinical trials for treating AIDS-related diarrhea, diarrhea associated with graft versus host disease following bone marrow transplant, and rotavirus diarrhea in children.
The U.S. Food and Drug Administration (FDA) has granted hyperimmune bovine colostrum "orphan drug status." Under the Orphan Drug Law, drug makers who invest in the development of treatments for rare conditions enjoy special market advantages; for example, permission to sell the drug without competition for 7 years. If these special incentives were not in place, pharmaceutical companies might not develop drugs for rare conditions because the potential market is so small.
How does it work?Colostrum is collected from cows that have been vaccinated to produce antibodies that fight the bacteria that cause diarrheal disease. These antibodies appear in the colostrum that is collected as medicine. Though the hope is that these cow antibodies will help fight human disease, the cow antibodies do not seem to be very active in humans.
Uses & Effectiveness
Possibly Effective for
- Upper airway infection in people who exercise. Research shows that taking bovine colostrum by mouth for 8-12 weeks can reduce of the number of episodes and symptoms of upper airway infections in people who exercise.
- Infectious diarrhea. Taking bovine colostrum seems to prevent infectious diarrhea from developing in adults, as well as children with a history of infectious diarrhea. It also seems to treat infectious diarrhea that has already developed in children. But it doesn't appear to speed recovery from infectious diarrhea in children who are also taking an antibiotic.
- Diarrhea in people with HIV. Taking bovine colostrum helps reduce diarrhea in people with HIV. Most research has used hyperimmune bovine colostrum.
- The flu (influenza). Taking a specific type of bovine colostrum (Ad Colostrum, Corcon srl) by mouth for 8 weeks helps prevent the flu, including in people that have already been vaccinated against the flu and in people with heart disease who have a higher risk of getting the flu.
- Rotaviral diarrhea. Taking bovine colostrum seems to reduce diarrhea in children with diarrhea due to rotavirus. Most research has used hyperimmune bovine colostrum.
Insufficient Evidence for
- Muscle loss in the elderly. Some research shows that taking a specific bovine colostrum product (Eterna Gold, Saskatoon Colostrum Co. Ltd.) improves leg strength but not upper body strength or body composition in older adults doing some weight training.
- Athletic performance. Early research shows that bovine colostrum might increase athletic performance for some athletic activities. However, it does not seem to work for rowing or strength training.
- Memory (cognitive function). Early research shows that taking bovine colostrum does not improve memory in older adults also taking part in an exercise program.
- Diabetes. Early research shows taking bovine colostrum might help to reduce levels of blood sugar following a meal, as well as cholesterol levels in people with type 2 diabetes.
- Inflammation of the colon (colitis). There is some early evidence that a rectal enema containing 10% bovine colostrum might be helpful for treating colitis.
- Reduced health in young children (failure to thrive). In young children that are not growing well, early research suggests taking bovine colostrum by mouth improves weight but not height.
- Human papilloma virus (HPV). Early research shows that applying bovine colostrum to the vagina for 6 months helps cure cervical lesions in people with HPV.
- Multiple sclerosis (MS). Taking hyperimmune bovine colostrum might help treat symptoms of MS, but not all research agrees.
- Upper airway infection. Research shows that taking bovine colostrum protein helps prevent upper airway infections in adult men. However, it doesn't appear to reduce the duration of upper airway infections if they do occur. Bovine colostrum also seems to reduce the number of upper airway infections in children who get them frequently.
- Thinning of the vaginal wall (vulvovaginal atrophy). Early research shows that applying a cream containing bovine colostrum and other ingredients in the vagina helps improve the thinning of the vaginal wall that occurs after menopause.
- Bacterial and fungal infections.
- Building lean muscle.
- Burning fat.
- Dry eyes.
- Elevating mood and sense of well-being.
- Healing injuries.
- Increasing stamina and vitality.
- Inflammation in the mouth.
- Repairing nervous system damage.
- Stimulating the immune system.
- Slowing and reversing aging.
- Other conditions.
Side Effects & SafetyBovine colostrum is LIKELY SAFE for most adults when taken appropriately by mouth. When it is given rectally as an enema, or in the vagina as a cream or tablets, it is POSSIBLY SAFE for most people. While most people don't experience any side effects from bovine colostrum, there have been rare reports of problems in HIV-positive people such as nausea, vomiting, abnormal liver function tests, and decreased red blood cells.
There is some concern about the possibility of catching "mad cow disease" (bovine spongiform encephalitis, BSE) or other diseases from products that come from animals. "Mad cow disease" does not appear to be transmitted through milk products, but it is probably wise to avoid animal products from countries where "mad cow disease" has been found.
Special Precautions & Warnings:Children: Bovine colostrum is POSSIBLY SAFE when taken appropriately by mouth in children.
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking bovine colostrum if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
Allergy to cow's milk: If you are allergic to cow's milk or milk products, you may also be allergic to bovine colostrum. In that case, it is best to avoid it.
We currently have no information for BOVINE COLOSTRUM Interactions.
The following doses have been studied in scientific research:
- For preventing upper airway infections in people who exercise: 10-20 grams of bovine colostrum daily for 8-12 weeks has been used.
- For diarrhea in people with HIV: 10-30 grams of bovine colostrum powder has been taken 1-4 times daily for 10-21 days.
- For the flu (influenza): 400 mg of a defatted freeze-dried bovine colostrum daily for 8 weeks has been used.
- For infectious diarrhea: 7 grams of bovine colostrum three times daily for 14 days has been used. For preventing infectious diarrhea, 3 grams of bovine colostrum once daily for 4 weeks has been used in children under 1-2 years-old, and 3 grams twice daily for 4 weeks has been used in children 2-6 years-old.
- For rotaviral diarrhea: 10 grams of bovine colostrum daily for 4 days, or 20-300 mL daily for up to 2 weeks, has been used.
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- Pedersen, A. M., Andersen, T. L., Reibel, J., Holmstrup, P., and Nauntofte, B. Oral findings in patients with primary Sjogren's syndrome and oral lichen planus--a preliminary study on the effects of bovine colostrum-containing oral hygiene products. Clin.Oral Investig. 2002;6(1):11-20. View abstract.
- Sambasivarao, D., Hooton, J., Dost, A., and Paetkau, V. A novel immunosuppressive factor in bovine colostrum blocks activation of the interleukin 2 gene enhancer at the NFAT site. Biochem.Cell Biol. 1996;74(4):585-593. View abstract.
- Saxon, A. and Weinstein, W. Oral administration of bovine colostrum anti-cryptosporidia antibody fails to alter the course of human cryptosporidiosis. J.Parasitol. 1987;73(2):413-415. View abstract.
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- Shing CM, Jenkins DG, Stevenson L, Coombes JS. The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists. Br J Sports Med 2006;40:797-801. View abstract.
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