All Spice, Allspice Essential Oil, Aqua Pimentae, Clove Pepper, Eugenia Piment, Eugenia pimenta, Jamaica Pepper, Jamaican Pepper, Piment de la Jamaïque, Pimenta dioica, Pimenta officinalis, Pimento, Pimienta de Jamaica, Poivre Anglais, Poivre Aromatique, Poivre de Jamaïque, Poivre de la Jamaïque, Quatre-Épices, Spanish Pimienta, Toute-Épice, Water of Pimento, West Pimenta Officinalis.


Overview Information

Allspice is a plant. The unripe berries and leaves of the plant are used to make medicine.

People use allspice for many conditions, but there is no good scientific evidence to support these uses.

In foods, allspice is used as a spice.

How does it work?

Allspice contains a chemical called eugenol, which might explain some of its traditional uses for toothache, muscle pain, and as a germ-killer. Other compounds in allspice seem to kill cancer cells.


Uses & Effectiveness?

Insufficient Evidence for

  • Intestinal gas.
  • Indigestion.
  • Vomiting.
  • Diarrhea.
  • Fever.
  • Flu.
  • Colds.
  • Heavy menstrual bleeding.
  • Menopause symptoms.
  • Emptying the bowels.
  • Other conditions.
More evidence is needed to rate the effectiveness of allspice for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Allspice is LIKELY SAFE for most adults when used as a spice. Some people are allergic to allspice. There isn't enough reliable information to know if allspice is safe to use as a medicine or what the side effects might be.

When applied to the skin: There isn't enough reliable information to know if allspice is safe or what the side effects might be. Some people are allergic to allspice.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if allspice is safe to use as a medicine when pregnant or breast-feeding. Stay on the safe side and avoid using amounts larger than those found in foods.

Surgery: Allspice can slow blood clotting. There is some concern that it might increase the chance of bleeding during and after surgery. Stop using allspice at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with ALLSPICE

    Allspice might slow blood clotting. Taking allspice along with medications that also slow clotting might increase the chances of bruising and bleeding.
    Allspice contains eugenol. Eugenol is the part of allspice that might slow blood clotting. Eugenol is very fragrant and gives allspice and cloves their distinctive smell.
    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



The appropriate dose of allspice depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for allspice. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Al-Rehaily and et al. Ethnopharmacological Studies on Allspice ( Pimenta dioica ) In Laboratory Animals. Pharmaceutical Biology 2002;40(3):200.
  • Doyle, B. J., Frasor, J., Bellows, L. E., Locklear, T. D., Perez, A., Gomez-Laurito, J., and Mahady, G. B. Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms. Menopause. 2009;16(4):748-755. View abstract.
  • Kikuzaki, H., Miyajima, Y., and Nakatani, N. Phenolic Glycosides from Berries of Pimenta dioica. J Nat.Prod. 3-4-2008; View abstract.
  • Kikuzaki, H., Sato, A., Mayahara, Y., and Nakatani, N. Galloylglucosides from berries of Pimenta dioica. J Nat.Prod. 2000;63(6):749-752. View abstract.
  • Logarto, Parra A., Silva, Yhebra R., Guerra, Sardinas, I, and Iglesias, Buela L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine. 2001;8(5):395-400. View abstract.
  • Marzouk, M. S., Moharram, F. A., Mohamed, M. A., Gamal-Eldeen, A. M., and Aboutabl, E. A. Anticancer and antioxidant tannins from Pimenta dioica leaves. Z.Naturforsch.[C.] 2007;62(7-8):526-536. View abstract.
  • Miyajima, Y., Kikuzaki, H., Hisamoto, M., and Nikatani, N. Antioxidative polyphenols from berries of Pimenta dioica. Biofactors 2004;21(1-4):301-303. View abstract.
  • Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. View abstract.
  • Doyle BJ, Lawal TO, Locklear TD, et al. Isolation and identification of three new chromones from the leaves of Pimenta dioica with cytotoxic, oestrogenic and anti-oestrogenic effects. Pharm Biol. 2018;56(1):235-244. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at:
  • Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. View abstract.
  • Padmakumari KP, Sasidharan I, Sreekumar MM. Composition and antioxidant activity of essential oil of pimento (Pimenta dioica (L) Merr.) from Jamaica. Nat Prod Res. 2011;25(2):152-60. View abstract.
  • Ramos A, Visozo A, Piloto J, et al. Screening of antimutagenicity via antioxidant activity in Cuban medicinal plants. J Ethnopharmacol 2003;87:241-6. View abstract.
  • Shamaladevi N, Lyn DA, Shaaban KA, et al. Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer. Carcinogenesis. 2013;34(8):1822-32. View abstract.
  • Suarez A, Ulate G, Ciccio JF. Cardiovascular effects of ethanolic and aqueous extracts of Pimenta dioica in Sprague-Dawley rats. J Ethnopharmacol 1997;55:107-11. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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