Ribose is used for heart disease, mental function, athletic performance, chronic fatigue syndrome (CFS), fibromyalgia, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Possibly Ineffective for
- Athletic performance. Taking ribose by mouth, alone or with other supplements, does not seem to improve power, muscle strength, or athletic performance in trained or untrained people.
Likely InEffective for
Insufficient Evidence for
- Chronic fatigue syndrome (CFS). Some early research shows that taking ribose by mouth might improve energy, sleep, and sense of well-being in people with CFS.
- Surgery to improve blood flow to the heart (CABG surgery). Some early research shows that people who take ribose by mouth immediately before surgery have better heart function after surgery.
- Heart disease. Early research shows that taking ribose by mouth seems to help reduce chest pain and improve the heart's ability to manage low blood flow in some people with heart disease.
- Heart failure and fluid build up in the body (congestive heart failure or CHF). Early research shows that taking ribose by mouth seems to improve quality of life and some measures of heart function in people with CHF.
- Fibromyalgia. Early research shows that taking ribose by mouth can improve energy, sleep, sense of well-being, and pain in people with fibromyalgia.
- Memory and thinking skills (cognitive function). Early research shows that taking ribose by mouth does not appear to improve mental function during tasks that cause mental tiredness.
- An inherited disease that affects muscles used for movement (myoadenylate deaminase deficiency or MAD). Research in a few people with MAD suggests that taking ribose by mouth might help prevent cramping, pain, and stiffness after exercise.
- A disorder that causes leg discomfort and an irresistible urge to move the legs (restless legs syndrome or RLS). Some early research shows that taking ribose by mouth with meals improves symptoms of restless legs syndrome.
- Seizures not caused by epilepsy. Some early research shows that taking ribose by mouth might improve behavior and reduce the number of seizures in people with seizures caused by a deficiency of the chemical adenylosuccinase.
When given by IV: Ribose is LIKELY SAFE when administered by a healthcare provider.
Special Precautions and Warnings
Diabetes: Ribose might lower blood sugar. When used along with diabetes medications that lower blood sugar, it might make blood sugar drop too low. It's best not to use ribose if you have diabetes.
Surgery: Since ribose might lower blood sugar, there is a concern that it might interfere with blood sugar control during and after surgery. Stop taking ribose at least 2 weeks before a scheduled surgery.
Insulin interacts with RIBOSE
Ribose might decrease blood sugar. Insulin is also used to decrease blood sugar. Taking ribose along with insulin might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
Medications for diabetes (Antidiabetes drugs) interacts with RIBOSE
Ribose might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking ribose along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Be cautious with this combination
Alcohol interacts with RIBOSE
Alcohol might decrease your blood sugar. Ribose might also decrease your blood sugar. Taking ribose along with alcohol might cause your blood sugar to go too low.
Aspirin interacts with RIBOSE
Ribose might decrease blood sugar. Large amounts of aspirin might also decrease blood sugar. Taking ribose along with large amounts of aspirin might cause your blood sugar to go too low. But this interaction probably isn't a big concern for most people that take 81 mg of aspirin a day.
Choline Magnesium Trisalicylate (Trilisate) interacts with RIBOSE
Choline magnesium trisalicylate (Trilisate) might decrease your blood sugar. Ribose might also decrease blood sugar. Taking ribose along with choline magnesium trisalicylate (Trilisate) might cause your blood sugar to be too low. But it is not clear if this interaction is a big concern.
Propranolol (Inderal) interacts with RIBOSE
Propanolol (Inderal) might decrease blood sugar. Ribose might also decrease blood sugar. Taking ribose along with propanolol (Inderal) might cause your blood sugar to go too low.
Salsalate (Disalcid) interacts with RIBOSE
Large amounts of salsalate (Disalcid) can cause blood sugar to become low. Taking salsalate along with ribose might cause blood sugar to become too low.
Be watchful with this combination
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