7-KETO-DHEA
OTHER NAME(S):
(3-beta)-3-hydroxyandrost-5-ene-7,17-dione; (3S,8R,9S,10R,13R,14S)-3-hydroxy-10,13-dimethyl-2,3,4,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17-dione, 3-acetyl-7-oxo-dehydroepiandrosterone, 3-acetyl-7-oxo-DHEA, 3-beta-acetoxy-androst-5-ene-7,17-dione, 3-acetoxyandrost-5-ene-7,17-dione, 5-androsten-3-beta-17-one-DHEA, 5-androsten-3-beta-ol-7,17-dione, 7-Keto, 7-Keto Dehydroepiandrosterone, 7-Keto Déhydroépiandrostérone, 7-Keto DHEA, 7-Keto DHEA Acetate, 7-Keto-DHEA-THP, 7-ODA, 7-oxo-dehydroepiandrosterone, 7-oxo-dehydroepiandrosterone-3-acetate, 7-oxo-DHEA, 7-oxo-DHEA-acetate, 7-oxoprasterone, Acétate 7-Keto DHEA, DHEA acetate-7-one. <br/><br/>
OverviewUses
Side Effects
Interactions
Dosing
Uses & Effectiveness
Insufficient Evidence for
- Promoting weight loss. Early research shows that taking 7-keto-DHEA along with exercise might help obese adults lose weight and fat.
- Improving lean body mass.
- Building muscle.
- Increasing activity of the thyroid gland.
- Boosting the immune system.
- Enhancing memory.
- Reducing signs of aging.
- Depression.
- Anxiety.
- Post-traumatic stress disorder (PTSD).
- Other conditions.
Interactions
We currently have no information for 7-KETO-DHEA Interactions.
Dosing
BY MOUTH:
- For weight loss: 100 mg twice daily has been used.
REFERENCES:
- 7-keto-DHEA patents. Google Patents: www.google.com/patents/ (accessed 10/17/16).
- Amato RJ, Hulin MW, Winsauer PJ. A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule. Behav Pharmacol 2012;23(3):250-61. View abstract.
- Bobyleva V, Bellei M, Kneer N, Lardy H. The effects of ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Arch Biochem Biophys 1997;341:122-8. View abstract.
- Colker CM, Torina GC, Swain MA, Kalman DS. Double-Blind Study Evaluating the Effects of Exercise Plus 3-Acetyl-7-oxo-dehydroepiandrosterone on Body Composition and the Endocrine System in Overweight Adults. Abstract presented at 2nd ASEP Annual Meeting, October 14-16, 1999, and published in Journal of Exercise Physiology online, Volume 2 Number 4 October 1999.
- Davidson M, Marwah A, Sawchuk RJ, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med 2000;23:300-10.. View abstract.
- Davidson MH, Weeks C, Lardy H, et al. Clinical Safety and Endocrine Effects of 7-KETO-DHEA. Abstract presented at: Experimental Biology 98, April 19-22, 1998, San Francisco, CA. Abstract obtained from Humanetics Corporation website.
- Hampl R, Sulcova J, Bilek R, Hill M. How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influences thyroid function. Physiol Res 2006;55:49-54. View abstract.
- Ihler G, Chami-Stemmann H. 7-oxo-DHEA and Raynaud's phenomenon. Medical Hypotheses 2003;60(3):391-7. View abstract.
- Kalman DS, Colker CM, Swain MA, et al. A randomized double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Curr Ther Res 2000;61(7):435-42.
- Lardy H, Partridge B, Kneer N, Wei Y. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc Natl Acad Sci U S A 1995;92:6617-9. View abstract.
- Nelson R, Herron M, Weeks C, Lardy H. Dehydroepiandrosterone and 7-KETO-DHEA augment Interleukin 2 (IL2) Production by Human Lymphocytes In Vitro. Abstract presented at: The 5th Conference on Retroviruses and Opportunistic Infections, February 1-5, 1998, Chicago, IL. Abstract obtained from Humanetics Corporation.
- Shi J, Schulze S, Lardy HA. The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids 2000;65:124-9. View abstract.
- Sulcova J, Hampl R, Hill M, Starka L, Novacek A. Delayed effects of short-term transdermal applications of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers. Clin Chem Lab Med 2005;43(2):221-7. View abstract.
- Sulcova J, Hill M, Masek Z, et al. Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. Physiol Res 2001;50:9-18.. View abstract.
- US FDA. New Dietary Ingredients in Dietary Supplements - Background for Industry. www.fda.gov/Food/DietarySupplements/ucm109764.htm#new_din (accessed 10/16/16).
- Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-34. View abstract.