PANTOTHENIC ACID (VITAMIN B5)

OTHER NAME(S):

Acide D-Pantothénique, Acide Pantothénique, Ácido Pantoténico, Alcool Pantothénylique, B Complex Vitamin, Calcii Pantothenas, Calcium D-Pantothenate, Calcium Pantothenate, Complexe de Vitamines B, D-Calcium Pantothenate, D-Panthenol, D-Panthénol, D-Pantothénate de Calcium, D-Pantothenic Acid, D-Pantothenyl Alcohol, Dexpanthenol, Dexpanthénol, Dexpanthenolum, Pantéthine, Panthenol, Panthénol, Pantothenate, Pantothénate, Pantothénate de Calcium, Pantothenol, Pantothenylol, Vitamin B5, Vitamin B-5, Vitamina B5, Vitamine B5.

Overview

Overview Information

Pantothenic acid is a vitamin, also known as vitamin B5. It is widely found in both plants and animals including meat, vegetables, cereal grains, legumes, eggs, and milk.

Vitamin B5 is commercially available as D-pantothenic acid, as well as dexpanthenol and calcium pantothenate, which are chemicals made in the lab from D-pantothenic acid.

Pantothenic acid is frequently used in combination with other B vitamins in vitamin B complex formulations. Vitamin B complex generally includes vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid. However, some products do not contain all of these ingredients and some may include others, such as biotin, para-aminobenzoic acid (PABA), choline bitartrate, and inositol.

Pantothenic acid is used for pantothenic acid deficiency. Dexpanthenol, a chemical similar to pantothenic acid, is used for skin irritation, nasal swelling and irritation, and other conditions, but there is no good scientific research to support these uses.

How does it work?

Pantothenic acid is important for our bodies to properly use carbohydrates, proteins, and lipids and for healthy skin.

Uses

Uses & Effectiveness?

Effective for

  • Pantothenic acid deficiency. Taking pantothenic acid by mouth prevents and treats pantothenic acid deficiency.

Possibly Ineffective for

  • Skin damage caused by radiation therapy (radiation dermatitis). Applying dexpanthenol, a chemical similar to pantothenic acid, to areas of irritated skin does not seem to reduce skin damage caused by radiation therapy.

Insufficient Evidence for

  • Constipation. Early research suggests that taking dexpanthenol, a chemical similar to pantothenic acid, by mouth daily or receiving dexpanthenol shots can help treat constipation.
  • Eye trauma. Early research shows that applying drops containing dexpanthenol, a chemical similar to pantothenic acid, reduces eye pain and discomfort after surgery to the retinal. But applying dexpanthenol ointment doesn't seem to help improve wound healing after surgery to the cornea.
  • Osteoarthritis. Early research suggests that pantothenic acid (given as calcium pantothenate) does not reduce symptoms of osteoarthritis.
  • Impaired movement of food through the intestines after surgery. Taking pantothenic acid or dexpanthenol, a chemical similar to pantothenic acid, does not seem to improve bowel function after gallbladder removal.
  • Sore throat after surgery. Taking lozenges containing dexpanthenol, a chemical similar to pantothenic acid, before surgery might reduce sore throat symptoms after surgery.
  • Rheumatoid arthritis (RA). Early research suggests that pantothenic acid (given as calcium pantothenate) does not reduce the symptoms in people with rheumatoid arthritis.
  • Swelling (inflammation) of the nasal cavity and sinuses (rhinosinusitis). Early research suggests that using a nasal spray containing dexpanthenol, a chemical similar to pantothenic acid, after sinus surgery reduces discharge from the nose, but not other symptoms.
  • Skin irritation. Applying dexpanthenol, a chemical similar to pantothenic acid, does not seem to prevent skin irritation caused by a certain chemical in soap. But it might help treat this type of skin irritation.
  • Acne.
  • Aging.
  • Alcoholism.
  • Allergies.
  • Asthma.
  • Athletic performance.
  • Attention deficit-hyperactivity disorder (ADHD).
  • Autism.
  • Bladder infections.
  • Burning feet syndrome.
  • Carpal tunnel syndrome.
  • Celiac disease.
  • Chronic fatigue syndrome.
  • Colitis.
  • Convulsions.
  • Dandruff.
  • Delayed growth.
  • Depression.
  • Diabetic problems.
  • Enhancing immune function.
  • Eye infections (conjunctivitis).
  • Gray hair.
  • Hair loss.
  • Headache.
  • Heart problems.
  • Hyperactivity.
  • Hypoglycemia.
  • Inability to sleep (insomnia).
  • Irritability.
  • Kidney disorders.
  • Low blood pressure.
  • Lung disorders.
  • Multiple sclerosis (MS).
  • Muscle cramps.
  • Muscular dystrophy.
  • Osteoarthritis.
  • Parkinson disease.
  • Premenstrual syndrome (PMS).
  • Rheumatoid arthritis.
  • Side effects of thyroid medication and other medications.
  • Shingles (herpes zoster).
  • Skin disorders.
  • Stress.
  • Swelling of the prostate.
  • Yeast infections.
  • Vertigo.
  • Wound healing.
  • Eczema (atopic dermatitis), when applied to the skin.
  • Insect stings, when applied to the skin.
  • Rash, when applied to the skin.
  • Dry eye, when applied to the skin.
  • Sprains, when applied to the skin.
  • Promoting movement in the intestines, when given as a shot.
  • Other conditions.
More evidence is needed to rate the effectiveness of pantothenic acid for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Pantothenic acid is LIKELY SAFE for most people when taken by mouth in appropriate amounts. The recommended amount for adults is 5 mg per day. Even larger amounts (up to 10 grams) seem to be safe for some people. But taking larger amounts increases the chance of having side effects such as diarrhea.

When applied to the skin: Dexpanthenol, a chemical similar to pantothenic acid, is POSSIBLY SAFE when applied to the skin, short-term.

When given as a nasal spray: Dexpanthenol, a chemical similar to pantothenic acid, is POSSIBLY SAFE when used as a nasal spray, short-term.

When given as a shot: Dexpanthenol, a chemical similar to pantothenic acid, is POSSIBLY SAFE when injected as a shot into the muscle appropriately, short-term.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Pantothenic acid is LIKELY SAFE when taken by mouth in recommended amounts of 6 mg per day during pregnancy and 7 mg per day during breast-feeding. There isn't enough reliable information to know if taking more than these amounts is safe to use when pregnant or breast-feeding. Avoid using larger amounts of pantothenic acid.

Children: Dexpanthenol, a chemical similar to pantothenic acid, is POSSIBLY SAFE for children when applied to the skin.

Hemophila: Do not take dexpanthenol, a chemical similar to pantothenic acid, if you have hemophila. It might increase the risk of bleeding.

Stomach blockage: Do not receive injections of dexpanthenol, a chemical similar to pantothenic acid, if you have a gastrointestinal blockage.

Ulcerative colitis: Use enemas containing dexpanthenol, a chemical similar to pantothenic acid, cautiously if you have ulcerative colitis.

Interactions

Interactions?

We currently have no information for PANTOTHENIC ACID (VITAMIN B5) Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • General: Dietary Reference Intakes (DRI) are based on adequate intakes (AI) for pantothenic acid (vitamin B5) and are as follows: Infants 0-6 months, 1.7 mg; infants 7-12 months, 1.8 mg; children 1-3 years, 2 mg; children 4-8 years, 3 mg; children 9-13 years, 4 mg; men and women 14 years and older, 5 mg; pregnant women, 6 mg; and breast-feeding women, 7 mg.
  • For pantothenic acid deficiency: 5-10 mg of pantothenic acid (vitamin B5).

View References

REFERENCES:

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