HOPS

OTHER NAME(S):

Asperge Sauvage, Common Hops, Couleuvrée, Couleuvrée Septentrionale, European Hops, Hop, Hop Strobile, Hopfenzapfen, Houblon, Humulus lupulus, Lupuli Strobulus, Lupulin, Lúpulo, Pi Jiu Hua, Salsepareille Indigène, Vigne du Nord.<br/><br/>

Overview

Overview Information

Hops is a plant. The dried, flowering part of the plant is used to make medicine.

Hops is used for anxiety, inability to sleep (insomnia) and other sleep disorders, restlessness, tension, excitability, attention deficit-hyperactivity disorder (ADHD), nervousness, and irritability. It is also used to improve appetite, increase urine flow, start the flow of breast milk, as a bitter tonic, and for indigestion. Other uses include prostate cancer, breast cancer, ovarian cancer, high cholesterol, tuberculosis, bladder infections, intestinal cramps, an intestinal disorder called mucous colitis, nerve pain, and prolonged painful erection of the penis (priapism).

Hops is sometimes applied to the skin for leg ulcers and as an antibacterial agent.

In foods and beverages, the extracts and oil are used as flavor components. Hops are also used in brewing beer.

In manufacturing, the extract is used in skin creams and lotions.

How does it work?

The chemicals in hops seem to have weak estrogen effects.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Body odor. Early research suggests that applying a deodorant that contains hops and a specific zinc salt to the underarm can reduce body odor.
  • Insomnia. Some research suggests that taking a combination of hops extract plus valerian extract at bedtime helps some people fall asleep faster. It appears to take 28 days of treatment to see these benefits. However, a combination of valerian extract and hops extract seems to improve sleep quality similarly to bromazepam (Lexotanil) when taken for only 14 days. Sleep quality does not appear to be improved by taking a combination of hops, soya oil, soya lecithin, and Cannabis sativa (Cyclamax) for one month.
  • Menopausal symptoms. Early research suggests that taking hops extract daily does not improve menopausal symptoms after 8-12 weeks of treatment. However, it might improve the severity of hot flashes after 6 weeks of treatment.
  • Postmenopausal conditions. Some research suggests that applying 1-2 grams of a vaginal gel that contains hops, hyaluronic acid, liposomes, and vitamin E can reduce vaginal dryness, burning, itching, and rash in postmenopausal women.
  • Leg ulcers. Early research suggests that applying a cream containing bladderwrack, English ivy, horse chestnut, gotu kola, butcher’s broom, horsetail, and hops (Idrastin), together with compression therapy, might help decrease pain and inflammation in people with leg ulcers and poor blood circulation in the legs.
  • Tenseness.
  • Attention deficit-hyperactivity disorder (ADHD).
  • Improving appetite.
  • Indigestion.
  • Prostate cancer.
  • Breast cancer.
  • Ovarian cancer.
  • High cholesterol.
  • Intestinal cramps.
  • Tuberculosis.
  • Pain and swelling (inflammation) of the bladder.
  • Nerve pain.
  • Start the flow of breast milk.
  • Other conditions.
More evidence is needed to rate the effectiveness of hops for these uses.

Side Effects

Side Effects & Safety

Hops are considered LIKELY SAFE when consumed in amounts commonly found in foods. Hops are POSSIBLY SAFE when taken by mouth for medicinal uses.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hops if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Depression: Hops may make depression worse. Avoid use.

Hormone sensitive cancers and conditions: Some chemicals in hops act like estrogen. People who have conditions that are sensitive to hormones should avoid hops. Some of these conditions including breast cancer and endometriosis.

Surgery: Hops might cause too much sleepiness when combined with anesthesia and other medications during and after surgical procedures. Stop taking hops at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Alcohol interacts with HOPS

    Alcohol can cause sleepiness and drowsiness. Hops might also cause sleepiness and drowsiness. Taking large amounts of hops along with alcohol might cause too much sleepiness.

  • Sedative medications (CNS depressants) interacts with HOPS

    Hops might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hops along with sedative medications might cause too much sleepiness.<br/><br/> Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Dosing

Dosing

The appropriate dose of hops depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hops. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Babish, J. G., Pacioretty, L. M., Bland, J. S., Minich, D. M., Hu, J., and Tripp, M. L. Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice. J Med Food 2010;13(3):535-547. View abstract.
  • Behr, J. and Vogel, R. F. Mechanisms of hop inhibition include the transmembrane redox reaction. Appl.Environ Microbiol. 2010;76(1):142-149. View abstract.
  • Bolca, S., Li, J., Nikolic, D., Roche, N., Blondeel, P., Possemiers, S., De, Keukeleire D., Bracke, M., Heyerick, A., van Breemen, R. B., and Depypere, H. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res 2010;54 Suppl 2:S284-S294. View abstract.
  • Caballero, I., Agut, M., Armentia, A., and Blanco, C. A. Importance of tetrahydroiso alpha-acids to the microbiological stability of beer. J AOAC Int 2009;92(4):1160-1164. View abstract.
  • Casey, T. R. and Bamforth, C. W. Silicon in beer and brewing. J Sci Food Agric 4-15-2010;90(5):784-788. View abstract.
  • Cattoor, K., Bracke, M., Deforce, D., De, Keukeleire D., and Heyerick, A. Transport of hop bitter acids across intestinal Caco-2 cell monolayers. J Agric Food Chem 4-14-2010;58(7):4132-4140. View abstract.
  • Ceslova, L., Holcapek, M., Fidler, M., Drstickova, J., and Lisa, M. Characterization of prenylflavonoids and hop bitter acids in various classes of Czech beers and hop extracts using high-performance liquid chromatography-mass spectrometry. J Chromatogr.A 10-23-2009;1216(43):7249-7257. View abstract.
  • Chadwick, L. R., Nikolic, D., Burdette, J. E., Overk, C. R., Bolton, J. L., van Breemen, R. B., Frohlich, R., Fong, H. H., Farnsworth, N. R., and Pauli, G. F. Estrogens and congeners from spent hops (Humulus lupulus). J Nat.Prod. 2004;67(12):2024-2032. View abstract.
  • Chiummariello, S., De, Gado F., Monarca, C., Ruggiero, M., Carlesimo, B., Scuderi, N., and Alfano, C. [Multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs]. G.Chir 2009;30(11-12):497-501. View abstract.
  • Choi, Y., Jermihov, K., Nam, S. J., Sturdy, M., Maloney, K., Qiu, X., Chadwick, L. R., Main, M., Chen, S. N., Mesecar, A. D., Farnsworth, N. R., Pauli, G. F., Fenical, W., Pezzuto, J. M., and van Breemen, R. B. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal.Chem 2-1-2011;83(3):1048-1052. View abstract.
  • Chu, H. M., Ko, T. P., and Wang, A. H. Crystal structure and substrate specificity of plant adenylate isopentenyltransferase from Humulus lupulus: distinctive binding affinity for purine and pyrimidine nucleotides. Nucleic Acids Res 2010;38(5):1738-1748. View abstract.
  • Chung, W. G., Miranda, C. L., Stevens, J. F., and Maier, C. S. Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. Food Chem Toxicol. 2009;47(4):827-836. View abstract.
  • Cornu, C., Remontet, L., Noel-Baron, F., Nicolas, A., Feugier-Favier, N., Roy, P., Claustrat, B., Saadatian-Elahi, M., and Kassai, B. A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial. BMC.Complement Altern Med 2010;10:29. View abstract.
  • Deeb, D., Gao, X., Jiang, H., Arbab, A. S., Dulchavsky, S. A., and Gautam, S. C. Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells. Anticancer Res 2010;30(9):3333-3339. View abstract.
  • Dhooghe, L., Naessens, T., Heyerick, A., De, Keukeleire D., Vlietinck, A. J., Pieters, L., and Apers, S. Quantification of xanthohumol, isoxanthohumol, 8-prenylnaringenin, and 6-prenylnaringenin in hop extracts and derived capsules using secondary standards. Talanta 12-15-2010;83(2):448-456. View abstract.
  • Di, Viesti, V, Carnevale, G., Zavatti, M., Benelli, A., and Zanoli, P. Increased sexual motivation in female rats treated with Humulus lupulus L. extract. J Ethnopharmacol. 3-24-2011;134(2):514-517. View abstract.
  • Dietz, B. M. and Bolton, J. L. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chem Biol Interact. 6-30-2011;192(1-2):72-80. View abstract.
  • Dimpfel, W., Pischel, I., and Lehnfeld, R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. Eur.J Med Res 9-29-2004;9(9):423-431. View abstract.
  • Dorn, C., Bataille, F., Gaebele, E., Heilmann, J., and Hellerbrand, C. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food Chem Toxicol. 2010;48(7):1890-1897. View abstract.
  • Dorn, C., Kraus, B., Motyl, M., Weiss, T. S., Gehrig, M., Scholmerich, J., Heilmann, J., and Hellerbrand, C. Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Mol Nutr Food Res 2010;54 Suppl 2:S205-S213. View abstract.
  • Dorn, C., Weiss, T. S., Heilmann, J., and Hellerbrand, C. Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. Int J Oncol. 2010;36(2):435-441. View abstract.
  • Dumas, E. R., Michaud, A. E., Bergeron, C., Lafrance, J. L., Mortillo, S., and Gafner, S. Deodorant effects of a supercritical hops extract: antibacterial activity against Corynebacterium xerosis and Staphylococcus epidermidis and efficacy testing of a hops/zinc ricinoleate stick in humans through the sensory evaluation of axillary deodorancy. J Cosmet.Dermatol 2009;8(3):197-204. View abstract.
  • Duncan, K. L., Hare, W. R., and Buck, W. B. Malignant hyperthermia-like reaction secondary to ingestion of hops in five dogs. J Am Vet Med Assoc 1-1-1997;210(1):51-54. View abstract.
  • Erkkola, R., Vervarcke, S., Vansteelandt, S., Rompotti, P., De, Keukeleire D., and Heyerick, A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine. 2010;17(6):389-396. View abstract.
  • European Food Safety Authority. Modification of the existing MRL for acequinocyl in hops. EFSA Journal 2010;8(12)
  • European Food Safety Authority. Reasoned opinion of EFSA: modification of the current MRL for mandipropamid in hops. EFSA Journal 2011;9(2)
  • Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. View abstract.
  • Flesar, J., Havlik, J., Kloucek, P., Rada, V., Titera, D., Bednar, M., Stropnicky, M., and Kokoska, L. In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees. Vet.Microbiol. 9-28-2010;145(1-2):129-133. View abstract.
  • Foster, B. C., Arnason, J. T., Saleem, A., Tam, T. W., Liu, R., Mao, J., and Desjardins, S. Comparative study of hops-containing products on human cytochrome P450-mediated metabolism. J Agric Food Chem 5-11-2011;59(9):5159-5163. View abstract.
  • Foster, B. C., Kearns, N., Arnason, J. T., Saleem, A., Ogrodowczyk, C., and Desjardins, S. Comparative study of hop-containing products on human cytochrome p450-mediated metabolism. J Agric Food Chem 6-10-2009;57(11):5100-5105. View abstract.
  • Franco, L., Sanchez, C., Bravo, R., Rodriguez, A. B., Barriga, C., Romero, E., and Cubero, J. The sedative effect of non-alcoholic beer in healthy female nurses. PLoS.One. 2012;7(7):e37290. View abstract.
  • Gao, X., Deeb, D., Liu, Y., Gautam, S., Dulchavsky, S. A., and Gautam, S. C. Immunomodulatory activity of xanthohumol: inhibition of T cell proliferation, cell-mediated cytotoxicity and Th1 cytokine production through suppression of NF-kappaB. Immunopharmacol.Immunotoxicol. 2009;31(3):477-484. View abstract.
  • Gerhard, U., Linnenbrink, N., Georghiadou, C., and Hobi, V. Vigilanzmindernde Effekte zweier pflazlicher Schlafmittel (Effects of two plant-based sleep remedies on vigilance). Schweiz.Rundsch.Med.Prax. 4-9-1996;85(15):473-481. View abstract.
  • Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. View abstract.
  • Gora, A., Skorska, C., Sitkowska, J., Prazmo, Z., Krysinska-Traczyk, E., Urbanowicz, B., and Dutkiewicz, J. Exposure of hop growers to bioaerosols. Ann.Agric.Environ.Med 2004;11(1):129-138. View abstract.
  • Gross-Steinmeyer, K. and Eaton, D. L. Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1). Toxicology 9-28-2012;299(2-3):69-79. View abstract.
  • Hall, A. J., Babish, J. G., Darland, G. K., Carroll, B. J., Konda, V. R., Lerman, R. H., Bland, J. S., and Tripp, M. L. Safety, efficacy and anti-inflammatory activity of rho iso-alpha-acids from hops. Phytochemistry 2008;69(7):1534-1547. View abstract.
  • Hänsel R, Wohlfart R, and Schmidt H. The sedative-hypnotic principle of hops. 3. Communication: contents of 2-methyl-3-butene-2-ol in hops and hop preparations. Planta Med 1982;45:224-228.
  • Hansel, R., Wohlfart, R., and Coper, H. [Sedative-hypnotic compounds in the exhalation of hops, II]. Z.Naturforsch.[C.] 1980;35(11-12):1096-1097. View abstract.
  • Hartkorn, A., Hoffmann, F., Ajamieh, H., Vogel, S., Heilmann, J., Gerbes, A. L., Vollmar, A. M., and Zahler, S. Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury. J Nat Prod 2009;72(10):1741-1747. View abstract.
  • Heyerick, A., Vervarcke, S., Depypere, H., Bracke, M., and De Keukeleire, D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas 5-20-2006;54(2):164-175. View abstract.
  • Holick, M. F., Lamb, J. J., Lerman, R. H., Konda, V. R., Darland, G., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. J Bone Miner.Metab 2010;28(3):342-350. View abstract.
  • In: Bradley PR. British Herbal Compendium. Bournemouth, Dorset, UK: British Herbal Medicine Association;1992.
  • Izzo, G., Soder, O., and Svechnikov, K. The prenylflavonoid phytoestrogens 8-prenylnaringenin and isoxanthohumol diferentially suppress steroidogenesis in rat Leydig cells in ontogenesis. J Appl.Toxicol. 11-9-2010; View abstract.
  • Jakovljevic, V., Popovic, M., Raskovic, A., Sabo, A., and Vasic, R. Effect of aroma and magnum hops extracts and paracetamol on antioxidant liver parameters in mice. Eur J Drug Metab Pharmacokinet. 2008;33(4):205-209. View abstract.
  • Jakovljevic, V., Popovic, M., Raskovic, A., Sabo, A., Horvat, O., Mitic, R., and Vasic, R. Effect of aroma and magnum hops extracts and paracetamol on antioxidant liver parameters in mice. Eur J Drug Metab Pharmacokinet. 2009;34(1):37-41. View abstract.
  • Jirasko, R., Holcapek, M., Vrublova, E., Ulrichova, J., and Simanek, V. Identification of new phase II metabolites of xanthohumol in rat in vivo biotransformation of hop extracts using high-performance liquid chromatography electrospray ionization tandem mass spectrometry. J Chromatogr.A 6-18-2010;1217(25):4100-4108. View abstract.
  • Jones, J. L., Fernandez, M. L., McIntosh, M. S., Najm, W., Calle, M. C., Kalynych, C., Vukich, C., Barona, J., Ackermann, D., Kim, J. E., Kumar, V., Lott, M., Volek, J. S., and Lerman, R. H. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. J Clin Lipidol. 2011;5(3):188-196. View abstract.
  • Kermanshahi, R. K, Esfahani, B. N, Serkani, J. E, Asghari, G. R, and Babaie, A. A. P. The study of antibacterial effect of Humulus lupulus on some of Gram positive & Gram negative bacteria. Journal of Medicinal Plants 2009;8(30):92-97.
  • Kligler, B., Homel, P., Blank, A. E., Kenney, J., Levenson, H., and Merrell, W. Randomized trial of the effect of an integrative medicine approach to the management of asthma in adults on disease-related quality of life and pulmonary function. Altern.Ther.Health Med. 2011;17(1):10-15. View abstract.
  • Koetter, U and Biendl, M. HOPS. HerbalGram 2010;(87):44-57.
  • Komarek, M, Balík, J, Chrastný, V, and Száková, J. DISTRIBUTION AND FRACTIONATION OF COPPER IN CONTAMINATED HOP FIELD SOILS. Fresenius Environmental Bulletin 2009;18(7b):1319-1323.
  • Konda, V. R., Desai, A., Darland, G., Bland, J. S., and Tripp, M. L. Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradation. J Inflamm.(Lond) 2009;6:26. View abstract.
  • Kornysova, O., Stanius, Z., Obelevicius, K., Ragazinskiene, O., Skrzydlewska, E., and Maruska, A. Capillary zone electrophoresis method for determination of bitter (alpha- and beta-) acids in hop (Humulus lupulus L.) cone extracts. Adv.Med Sci 2009;54(1):41-46. View abstract.
  • Lamb, J. J., Holick, M. F., Lerman, R. H., Konda, V. R., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D(3), and vitamin K(1) produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome. Nutr Res 2011;31(5):347-355. View abstract.
  • Langezaal, C. R., Chandra, A., and Scheffer, J. J. Antimicrobial screening of essential oils and extracts of some Humulus lupulus L. cultivars. Pharm Weekbl Sci 12-11-1992;14(6):353-356. View abstract.
  • Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  • Lee, I. S., Lim, J., Gal, J., Kang, J. C., Kim, H. J., Kang, B. Y., and Choi, H. J. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem.Int 2011;58(2):153-160. View abstract.
  • Lerman, R. H., Minich, D. M., Darland, G., Lamb, J. J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Subjects with elevated LDL cholesterol and metabolic syndrome benefit from supplementation with soy protein, phytosterols, hops rho iso-alpha acids, and Acacia nilotica proanthocyanidins. J Clin Lipidol. 2010;4(1):59-68. View abstract.
  • Lopez-Jaen, A. B., Codoñer-Franch, P, Martínez-Álvarez, J. R., Villarino-Marín, A, and Valls-Bellés, V. Effect on health of non-alcohol beer and hop supplementation in a group of nuns in a closed order. Proceedings of the Nutrition Society 2010;69(OCE3):26.
  • Lupinacci, E., Meijerink, J., Vincken, J. P., Gabriele, B., Gruppen, H., and Witkamp, R. F. Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. J Agric Food Chem 8-26-2009;57(16):7274-7281. View abstract.
  • Magalhaes, P. J., Vieira, J. S., Goncalves, L. M., Pacheco, J. G., Guido, L. F., and Barros, A. A. Isolation of phenolic compounds from hop extracts using polyvinylpolypyrrolidone: characterization by high-performance liquid chromatography-diode array detection-electrospray tandem mass spectrometry. J Chromatogr.A 5-7-2010;1217(19):3258-3268. View abstract.
  • Mannering, G. J. and Shoeman, J. A. Murine cytochrome P4503A is induced by 2-methyl-3-buten-2-ol, 3-methyl- 1-pentyn-3-ol(meparfynol), and tert-amyl alcohol. Xenobiotica 1996;26(5):487-493. View abstract.
  • Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. View abstract.
  • Mannering, G. J., Shoeman, J. A., and Shoeman, D. W. Effects of colupulone, a component of hops and brewers yeast, and chromium on glucose tolerance and hepatic cytochrome P450 in nondiabetic and spontaneously diabetic mice. Biochem Biophys Res Commun 5-16-1994;200(3):1455-1462. View abstract.
  • Marinova, G and Batchvarov, V. Hop and beer polyphenols and their healthiness. Scientific Works of the University of Food Technologies - Plovdiv 2009;56(1):162-168.
  • Minich, D. M., Lerman, R. H., Darland, G., Babish, J. G., Pacioretty, L. M., Bland, J. S., and Tripp, M. L. Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome. J Nutr Metab 2010;2010 View abstract.
  • Miranda, C. L., Yang, Y. H., Henderson, M. C., Stevens, J. F., Santana-Rios, G., Deinzer, M. L., and Buhler, D. R. Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5- f]quinoline, mediated by cDNA-expressed human CYP1A2. Drug Metab Dispos 2000;28(11):1297-1302. View abstract.
  • Morali, G., Polatti, F., Metelitsa, E. N., Mascarucci, P., Magnani, P., and Marre, G. B. Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung 2006;56(3):230-238. View abstract.
  • Moreira, M. M., Carvalho, A. M., Valente, I. M., Goncalves, L. M., Rodrigues, J. A., Barros, A. A., and Guido, L. F. Novel application of square-wave adsorptive-stripping voltammetry for the determination of xanthohumol in spent hops. J Agric Food Chem 7-27-2011;59(14):7654-7658. View abstract.
  • Mozny, M, Tolasz, R, Nekovar, J., Sparks, T, Trnka, M, and Zalud, Z. The impact of climate change on the yield and quality of Saaz hops in the Czech Republic. Agricultural & Forest Meteorology 2009;149(6/7):913-919.
  • Negrao, R., Costa, R., Duarte, D., Taveira, Gomes T., Mendanha, M., Moura, L., Vasques, L., Azevedo, I., and Soares, R. Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells. J Cell Biochem 12-1-2010;111(5):1270-1279. View abstract.
  • Negri, G., Santi, D., and Tabach, R. Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic. Revista Brasileira de Farmacognosia 2010;20(6):850-859.
  • Olas, B., Kolodziejczyk, J., Wachowicz, B., Jedrejek, D., Stochmal, A., and Oleszek, W. The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets. Platelets. 2011;22(5):345-352. View abstract.
  • Peluso, M. R., Miranda, C. L., Hobbs, D. J., Proteau, R. R., and Stevens, J. F. Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). Planta Med 2010;76(14):1536-1543. View abstract.
  • Philips, N., Samuel, M., Arena, R., Chen, Y. J., Conte, J., Natarajan, P., Haas, G., and Gonzalez, S. Direct inhibition of elastase and matrixmetalloproteinases and stimulation of biosynthesis of fibrillar collagens, elastin, and fibrillins by xanthohumol. J Cosmet.Sci 2010;61(2):125-132. View abstract.
  • Possemiers, S., Bolca, S., Grootaert, C., Heyerick, A., Decroos, K., Dhooge, W., De, Keukeleire D., Rabot, S., Verstraete, W., and Van de Wiele, T. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr 2006;136(7):1862-1867. View abstract.
  • Radovic, B., Hussong, R., Gerhauser, C., Meinl, W., Frank, N., Becker, H., and Kohrle, J. Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. Mol Nutr Food Res 2010;54 Suppl 2:S225-S235. View abstract.
  • Ross, S. M. Sleep disorders: a single dose administration of valerian/hops fluid extract (dormeasan) is found to be effective in improving sleep. Holist.Nurs Pract 2009;23(4):253-256. View abstract.
  • Salter, S. and Brownie, S. Treating primary insomnia - the efficacy of valerian and hops. Aust.Fam.Physician 2010;39(6):433-437. View abstract.
  • Samojlov, Y. K., Lemza, V. D, Buchkov, P. P, and Loban, L. L. Biological protection of hop-plant. Progress in Plant Protection 2010;50(4):2013-2016.
  • Schellenberg, R., Sauer, S., Abourashed, E. A., Koetter, U., and Brattstrom, A. The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism. Planta Med 2004;70(7):594-597. View abstract.
  • Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. View abstract.
  • Shapouri, R and Rahnema, M. Evaluation of antimicrobial effect of hops extracts on intramacrophages Brucella abortus and B. melitensis. Jundishapur Journal of Microbiology 2011;4(Suppl 1):S51-S58.
  • Shen, C., Geornaras, I., Kendall, P. A., and Sofos, J. N. Control of Listeria monocytogenes on frankfurters by dipping in hops beta acids solutions. J Food Prot. 2009;72(4):702-706. View abstract.
  • Shou, C., Li, J., and Liu, Z. Complementary and alternative medicine in the treatment of menopausal symptoms. Chin J Integr Med 2011;17(12):883-888. View abstract.
  • Simpson, W. J. and Smith, A. R. Factors affecting antibacterial activity of hop compounds and their derivatives. J Appl Bacteriol. 1992;72(4):327-334. View abstract.
  • Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465. View abstract.
  • Stevens, J. F. and Page, J. E. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 2004;65(10):1317-1330. View abstract.
  • Stevens, J. F., Miranda, C. L., Frei, B., and Buhler, D. R. Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore. Chem Res Toxicol 2003;16(10):1277-1286. View abstract.
  • Stocker HR. Sedative und hypnogene Wirkung des Hopfens. Schweizerische Brauerei-Rundschau 1967;78(4):80-89.
  • Stracke, D., Schulz, T., and Prehm, P. Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions. Mol Nutr Food Res 2011;55(3):485-494. View abstract.
  • Strathmann, J., Klimo, K., Sauer, S. W., Okun, J. G., Prehn, J. H., and Gerhauser, C. Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism. FASEB J 2010;24(8):2938-2950. View abstract.
  • Swanston-Flatt, S. K., Day, C., Flatt, P. R., Gould, B. J., and Bailey, C. J. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res 1989;10(2):69-73. View abstract.
  • Takano, N., Inokuchi, Y., and Kurachi, M. [Effects of ethanol extracts of herbal medicines on dermatitis in an atopic dermatitis mouse model]. Yakugaku Zasshi 2011;131(4):581-586. View abstract.
  • Takoi, K., Degueil, M., Shinkaruk, S., Thibon, C., Maeda, K., Ito, K., Bennetau, B., Dubourdieu, D., and Tominaga, T. Identification and characteristics of new volatile thiols derived from the hop (Humulus luplus L.) cultivar Nelson Sauvin (dagger). J Agric Food Chem 3-25-2009;57(6):2493-2502. View abstract.
  • Tamasdan S, Cristea E, and Mihele D. Action upon gastric secretion of Robiniae flores, Chamomilae flores and Strobuli lupuli extracts. Farmacia 1981;29:71-75.
  • van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095. View abstract.
  • Van, Cleemput M., Cattoor, K., De, Bosscher K., Haegeman, G., De, Keukeleire D., and Heyerick, A. Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. J Nat Prod 2009;72(6):1220-1230. View abstract.
  • Van, Cleemput M., Heyerick, A., Libert, C., Swerts, K., Philippe, J., De, Keukeleire D., Haegeman, G., and De, Bosscher K. Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. Mol Nutr Food Res 2009;53(9):1143-1155. View abstract.
  • Vonderheid-Guth, B., Todorova, A., Brattstrom, A., and Dimpfel, W. Pharmacodynamic effects of valerian and hops extract combination (Ze 91019) on the quantitative-topographical EEG in healthy volunteers. Eur J Med Res 4-19-2000;5(4):139-144. View abstract.
  • Wang, G. and Dixon, R. A. Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis. Proc Natl Acad Sci U S A 6-16-2009;106(24):9914-9919. View abstract.
  • Wang, Y. J., Dou, J., Cross, K. P., and Valerio, L. G., Jr. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. Regul.Toxicol.Pharmacol. 2011;59(1):111-124. View abstract.
  • Weeks, B. S. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Med Sci Monit. 2009;15(11):RA256-RA262. View abstract.
  • Wohlfart, R., Hansel, R., and Schmidt, H. [The sedative-hypnotic action of hops. 4. Communication: pharmacology of the hop substance 2-methyl-3-buten-2-ol]. Planta Med 1983;48(2):120-123. View abstract.
  • Wohlfart, R., Wurm, G., Hansel, R., and Schmidt, H. [Detection of sedative-hypnotic active ingredients in hops. 5. Degradation of bitter acids to 2-methyl-3-buten-2-ol, a hop constituent with sedative-hypnotic activity]. Arch.Pharm.(Weinheim) 1983;316(2):132-137. View abstract.
  • Yadav, V. R., Prasad, S., Sung, B., and Aggarwal, B. B. The role of chalcones in suppression of NF-kappaB-mediated inflammation and cancer. Int Immunopharmacol. 2011;11(3):295-309. View abstract.
  • Yajima, H., Ikeshima, E., Shiraki, M., Kanaya, T., Fujiwara, D., Odai, H., Tsuboyama-Kasaoka, N., Ezaki, O., Oikawa, S., and Kondo, K. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. J Biol Chem 8-6-2004;279(32):33456-33462. View abstract.
  • Yamaguchi, N., Satoh-Yamaguchi, K., and Ono, M. In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris. Phytomedicine. 2009;16(4):369-376. View abstract.
  • Yasukawa, K., Takeuchi, M., and Takido, M. Humulon, a bitter in the hop, inhibits tumor promotion by 12-O- tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 1995;52(2):156-158. View abstract.
  • Zanoli, P., Zavatti, M., Rivasi, M., Benelli, A., Avallone, R., and Baraldi, M. Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naive male rats. J Ethnopharmacol. 8-17-2009;125(1):36-40. View abstract.
  • Zenisek A and Bednar IJ. Contribution of the identification of the estrogen activity of hops. Am Perfumer Arom 1960;75:61.
  • Zhang, N., Liu, Z., Han, Q., Chen, J., and Lv, Y. Xanthohumol enhances antiviral effect of interferon alpha-2b against bovine viral diarrhea virus, a surrogate of hepatitis C virus. Phytomedicine. 2010;17(5):310-316. View abstract.
  • Colgate EC, Miranda CL, Stevens JF, et al. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett 2007;246:201-9. View abstract.
  • Dixon-Shanies D, Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep 1999;6:1383-7.. View abstract.
  • Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. View abstract.
  • Leathwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982;17:65-71. View abstract.
  • Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-9.. View abstract.
  • Lukaczer D, Darland G, Tripp M, et al. A pilot trial evaluating Meta050, a proprietary combination of reduced iso-alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia. Phytother Res 2005;19(10):864-9. View abstract.
  • Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. View abstract.
  • Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. View abstract.
  • Miranda CL, Stevens JF, Helmrich A, et al. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem Toxicol 1999;37:271-85.. View abstract.
  • Monteiro R, Becker H, Azevedo I, Calhau C. Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity. Agric Food Chem 2006;54:2938-43. View abstract.
  • Morin CM, Koetter U, Bastien C, et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005;28:1465-71. View abstract.
  • Müller-Limmroth W, Ehrenstein W. [Experimental studies of the effects of Seda-Kneipp on the sleep of sleep disturbed subjects; implications for the treatment of different sleep disturbances (author's transl)]. Med Klin. 1977 Jun 24;72:1119-25. View abstract.
  • Nozawa H. Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun 2005;336:754-61. View abstract.
  • Overk CR, Yao P, Chadwick LR, et al. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem 2005;53:6246-53. View abstract.
  • Schmitz M, Jäckel M. [Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with a hops-valarian preparation and a benzodiazepine drug]. Wien Med Wochenschr. 1998;148:291-8. View abstract.
  • Sun J. Morning/evening menopausal formula relieves menopausal symptoms: a pilot study. J Altern Complement Med 2003;9:403-9. View abstract.
  • Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. View abstract.

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