Acide Diméthylaminoacétique, Dimethyl Glycine, Diméthylglycine, Dimethylglycine HCl, Diméthylglycine HCl, (Dimethylamino)acetic Acid, Dimetilglicina, DMG, DMG HCl, N,N-dimethylaminoacetic Acid, N,N-dimethylglycine, N,N-diméthylglycine, N,N Dimethylglycine HCl, N,N Diméthylglycine HCl, N-methylsarcosine.


Overview Information

Dimethylglycine is an amino acid, a building block for protein. It is found in the body in very small amounts and for only seconds at a time.

Dimethylglycine is used for attention deficit-hyperactivity disorder (ADHD), epilepsy, chronic fatigue syndrome (CFS), allergies, respiratory disorders, pain and swelling (inflammation), cancer, alcoholism, and drug addiction. It is also used to improve speech and behavior in autism, nervous system function, liver function, the body's use of oxygen, and athletic performance. Some people use it to reduce stress and the effects of aging, as well as boost the immune system's defenses against infection. Dimethylglycine is also used to lower bloodcholesterol and triglycerides, and to help bring blood pressure and blood sugar into normal range.

How does it work?

Dimethylglycine might help improve the way the body's immune system works.


Uses & Effectiveness?

Insufficient Evidence for

  • Athletic performance. Early clinical research shows that taking dimethylglycine daily for 3 weeks does not improve the performance of athletes.
  • Autism. Early clinical research shows that taking low doses of dimethylglycine daily for 1 month does not improve symptoms of autism.
  • Epilepsy. Early clinical research shows that taking dimethylglycine daily for 4 weeks does not improve generalized or akinetic/myoclonic seizures in patients with epilepsy.
  • Alcoholism.
  • Allergies.
  • Attention deficit-hyperactivity disorder (ADHD).
  • Breathing problems.
  • Cancer.
  • Chronic fatigue syndrome (CFS).
  • Drug addiction.
  • High blood pressure.
  • High cholesterol.
  • Improving the body's immune system.
  • Stress.
  • Other conditions.
More evidence is needed to rate the effectiveness of dimethylglycine for these uses.

Side Effects

Side Effects & Safety

Dimethylglycine is POSSIBLY SAFE when used short-term, for up to 28 days. The safety of long-term use is unknown.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking dimethylglycine if you are pregnant or breast feeding. Stay on the safe side and avoid use.



We currently have no information for DIMETHYLGLYCINE (DMG) Interactions.



The appropriate dose of dimethylglycine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for dimethylglycine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Bolman WM, Richmond JA. A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder. J Autism Dev Disord 1999;29:191-4. View abstract.
  • Freed WJ. N,N-dimethylglycine, betaine and seizures [letter]. Arch Neurol 1984;41:1129-30. View abstract.
  • Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav 1985;22:641-3. View abstract.
  • Gascon G, Patterson B, Yearwood K, Slotnick H. N,N-dimethylglycine and epilepsy. Epilepsia 1989;30:90-3. View abstract.
  • Graber CD, Goust JM, Glassman AD, et al. Immunomodulating properties of dimethylglycine in humans. J Infect Dis 1981;143:101-5. View abstract.
  • Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc 1982;14:424-7. View abstract.
  • Herbert V. N,N-dimethylglycine for epilepsy [letter]. N Engl J Med 1983;308:527-8.
  • Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res 1989;222:343-50. View abstract.
  • Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med 1990;115:481-6. View abstract.
  • Roach ES, Carlin L. N,N dimethylglycine for epilepsy [letter]. N Engl J Med 1982;307:1081-2.
  • Tonda ME, Hart LL. N,N-dimthylglycine and L-carnitine as performance enhancers in athletes. Ann Pharmacother 1992;26:935-7.
  • Ward TN, Smith EB, Reeves AG. Dimethylglycine and reduction of mortality in penicillin-induced seizures [letter]. Ann Neurol 1985;17:213.
  • Weiss RC. Immunologic responses in healthy random-source cats fed N,N-dimethylglycine-supplemented diets. Am J Vet Res 1992;53:829-33. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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