Dimethylis Sulfoxidum, Dimethyl Sulfoxide, Dimethyl Sulphoxide, Dimethylsulfoxide, Diméthylsulfoxyde, Dimetilsulfóxido, DMSO, Methyl Sulphoxide, NSC-763, SQ-9453, Sulfoxyde de Diméthyl, Sulphinybismethane.
Overview InformationDimethylsulfoxide (DMSO) is a chemical. It is available as a prescription medicine and also as a dietary supplement. It can be taken by mouth, applied to the skin (used topically), or injected into the veins (used intravenously or by IV).
DMSO is used for bladder inflammation (interstitial cystitis), limb pain that usually occurs after an injury (complex regional pain syndrome), and leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). It is also used for other conditions, but there is no good scientific evidence to support most of these uses.
How does it work?DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.
Uses & Effectiveness
- Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.
Possibly Effective for
- Limb pain that usually occurs after an injury (complex regional pain syndrome). Research suggests that applying DMSO 50% cream to the skin improves pain in people with this condition.
- Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein into the skin or surrounding tissue. Research suggests that applying DMSO to the skin might prevent further damage if this happens.
Possibly Ineffective for
- Hardening of skin and connective tissue (scleroderma). Most research suggests that applying DMSO to the skin does not help treat symptoms in people with a skin condition called scleroderma.
Insufficient Evidence for
- Abnormal protein buildup in the body (amyloidosis). Some early research suggests that applying DMSO to the skin, taking DMSO by mouth, or washing the bladder with DMSO might help treat amyloidosis.
- Foot sores in people with diabetes. Early research suggests that applying DMSO to the affected area might improve the healing of foot ulcers in people with diabetes.
- Shingles (herpes zoster). Research suggests that applying DMSO to the skin along with a drug called idoxuridine reduces lesions and swelling associated with shingles. But this effect is likely due to idoxuridine.
- Increased pressure within the skull (intracranial hypertension). Some evidence suggests that injecting DMSO intravenously (by IV) might help with this condition.
- Osteoarthritis. Early research suggests that applying DMSO to the skin might help decrease symptoms of osteoarthritis.
- Stomach ulcers. Early research suggests that taking DMSO might be more effective than the drug cimetidine for treating ulcers in people with ulcers.
- Bed sores (pressure ulcers). Early research suggests that applying DMSO 5% cream to the skin along with massage does not help prevent pressure ulcers in people living in nursing homes.
- Rheumatoid arthritis (RA). Early research suggests that applying DMSO to the skin might help decrease symptoms of rheumatoid arthritis (RA).
- Nerve pain caused by shingles (postherpetic neuralgia). Research suggests that applying DMSO to the skin along with a drug called idoxuridine reduces pain caused by shingles. But this effect is likely due to idoxuridine.
- Poor blood supply to a skin flap after surgery. Early research suggests that applying DMSO to the skin might help the skin heal after surgery.
- Painful conditions caused by overuse of tendons (tendinopathy). Early research suggests that applying DMSO 10% gel to the skin might improve pain and joint movement in people with tendon injuries.
- Eye problems.
- Gall stones.
- Muscle problems.
- Skin problems such as calluses.
- Other conditions.
Side Effects & SafetyWhen taken by mouth: There isn't enough reliable information to know if DMSO is safe or what the side effects might be.
When applied to the skin: Non-prescription DMSO is POSSIBLY UNSAFE. Some non-prescription DMSO products might be "industrial grade," which is not intended for human use. These products can contain impurities that can cause health issues. To make matters worse, DMSO is easily absorbed through the skin, so it carries these impurities rapidly into the body. Some side effects of taking DMSO include skin reactions, dry skin, headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation, breathing problems, and allergic reactions. DMSO also causes a garlic-like taste and breath and body odor.
When applied inside the bladder: DMSO is LIKELY SAFE when applied into the bladder as a prescription medication. Don't use DMSO products that are not prescribed by a healthcare professional.
When given by IV: There isn't enough reliable information to know if DMSO is safe. It might cause side effects such as blood problems, weakness, and confusion.
Special Precautions & Warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Diabetes: There are reports that topical use of DMSO can change how insulin works in the body. If you use insulin to treat diabetes and also use DMSO, monitor your blood sugar closely. Insulin doses may need to be adjusted.
Certain blood disorders. Injecting DMSO intravenously (by IV) might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.
Kidney problems: DMSO might harm the kidneys. Kidney function tests are recommended every 6 months if you use DMSO and have a kidney condition.
Liver problems: DMSO might harm the liver. If you have liver conditions and use DMSO, be sure to get liver function tests every 6 months.
Be cautious with this combination
Medications applied to the skin, eyes, or ears (Topical drugs) interacts with DIMETHYLSULFOXIDE (DMSO)
DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO along with medications you put on the skin or in the eyes or ears can increase how much medicine your body absorbs. Increasing how much medicine your body absorbs might increase the effects and side effects of the medicine.
Medications given as a shot (Injectable drugs) interacts with DIMETHYLSULFOXIDE (DMSO)
DMSO (dimethylsulfoxide) might help the body absorb some medicines. Using DMSO and getting a shot might increase how much medicine the body absorbs and increase the effects and side effects of medications given as a shot.
Medications taken by mouth (Oral drugs) interacts with DIMETHYLSULFOXIDE (DMSO)
DMSO (dimethylsulfoxide) might increase how much medicine your body absorbs. Taking DMSO along with medications taken by mouth might increase how much medicine your body absorbs. Increasing how much medicine your body absorbs can increase the effects and side effects of your medicines.
The following doses have been studied in scientific research:
APPLIED TO THE SKIN:
- For limb pain that usually occurs after an injury (complex regional pain syndrome): Applying a cream containing 50% DMSO to the affected area has been used up to five times daily for 2-12 months.
- For leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation): A dressing containing 77% to 90% DMSO solution has been applied every 3-8 hours for up to 2 weeks.
- For painful bladder syndrome (interstitial cystitis): Healthcare providers drip a DMSO solution into the bladder using a tube called a catheter. The catheter is removed and the patient is asked to hold the solution for a period of time before urinating.
- Aliaga, A., Armijo, M., Camacho, F., Castro, A., Cruces, M., Diaz, J. L., Fernandez, J. M., Iglesias, L., Ledo, A., Mascaro, J. M., and . [A topical solution of 40% idoxuridine in dimethyl sulfoxide compared to oral acyclovir in the treatment of herpes zoster. A double-blind multicenter clinical trial]. Med.Clin (Barc.) 2-22-1992;98(7):245-249. View abstract.
- Bertelli, G., Dini, D., Forno, G., Gozza, A., Venturini, M., Ballella, G., and Rosso, R. Dimethylsulphoxide and cooling after extravasation of antitumour agents. Lancet 4-24-1993;341(8852):1098-1099. View abstract.
- Bertelli, G., Gozza, A., Forno, G. B., Vidili, M. G., Silvestro, S., Venturini, M., Del Mastro, L., Garrone, O., Rosso, R., and Dini, D. Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study. J.Clin Oncol. 1995;13(11):2851-2855. View abstract.
- Binder, I. and van, Ophoven A. [The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 1: Background and basic principles]. Aktuelle Urol. 2008;39(3):205-214. View abstract.
- Binder, I., Rossbach, G., and van, Ophoven A. [The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment]. Aktuelle Urol. 2008;39(4):289-297. View abstract.
- Bonnetblanc, J. M., Bordessoule, D., Fayol, J., and Amici, J. M. [Treatment of accidental extravasation of antitumor agents with dimethylsulfoxide and alpha-tocopherol]. Ann Dermatol Venereol. 1996;123(10):640-643. View abstract.
- Brien, S., Prescott, P., Bashir, N., Lewith, H., and Lewith, G. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis.Cartilage. 2008;16(11):1277-1288. View abstract.
- Bulum, T., Prkacin, I., Cavric, G., Sobocan, N., Skurla, B., Duvnjak, L., and Bulimbasic, S. [Secondary (AA) amyloidosis in Crohn's disease]. Acta Med Croatica 2011;65(3):271-278. View abstract.
- Dawson, T. E. and Jamison, J. Intravesical treatments for painful bladder syndrome/ interstitial cystitis. Cochrane.Database.Syst.Rev 2007;(4):CD006113. View abstract.
- Demir, E., Kilciler, M., Bedir, S., Erten, K., and Ozgok, Y. Comparing two local anesthesia techniques for extracorporeal shock wave lithotripsy. Urology 2007;69(4):625-628. View abstract.
- Duimel-Peeters, I. G., Halfens, J. G., Ambergen, A. W., Houwing, R. H., Berger, P. F., and Snoeckx, L. H. The effectiveness of massage with and without dimethyl sulfoxide in preventing pressure ulcers: a randomized, double-blind cross-over trial in patients prone to pressure ulcers. Int J Nurs Stud 2007;44(8):1285-1295. View abstract.
- Fall, M., Oberpenning, F., and Peeker, R. Treatment of bladder pain syndrome/interstitial cystitis 2008: can we make evidence-based decisions? Eur Urol. 2008;54(1):65-75. View abstract.
- Flores-Carreras, O., Martinez-Espinoza, C. J., and Gonzalez-Ruiz, M. I. [Experience in the treatment of interstitial cystitis: review of 17 cases]. Ginecol.Obstet Mex. 2011;79(3):125-130. View abstract.
- Geertzen, J. H., de Bruijn, H., Bruijn-Kofman, A. T., and Arendzen, J. H. Reflex sympathetic dystrophy: early treatment and psychological aspects. Arch.Phys.Med.Rehabil. 1994;75(4):442-446. View abstract.
- Goris, R. J., Dongen, L. M., and Winters, H. A. Are toxic oxygen radicals involved in the pathogenesis of reflex sympathetic dystrophy? Free Radic.Res Commun. 1987;3(1-5):13-18. View abstract.
- Hoang, B. X., Levine, S. A., Shaw, D. G., Tran, D. M., Tran, H. Q., Nguyen, P. M., Tran, H. D., Hoang, C., and Pham, P. T. Dimethyl sulfoxide as an excitatory modulator and its possible role in cancer pain management. Inflamm.Allergy Drug Targets. 2010;9(4):306-312. View abstract.
- Hoang, B. X., Tran, D. M., Tran, H. Q., Nguyen, P. T., Pham, T. D., Dang, H. V., Ha, T. V., Tran, H. D., Hoang, C., Luong, K. N., and Shaw, D. G. Dimethyl sulfoxide and sodium bicarbonate in the treatment of refractory cancer pain. J Pain Palliat.Care Pharmacother. 2011;25(1):19-24. View abstract.
- Juel-Jensen, B. E., MacCallum, F. O., Mackenzie, A. M., and Pike, M. C. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 12-26-1970;4(5738):776-780. View abstract.
- Kneer, W., Kuhnau, S., Bias, P., and Haag, R. F. [Dimethylsulfoxide (DMSO) gel in treatment of acute tendopathies. A multicenter, placebo-controlled, randomized study]. Fortschr.Med. 4-10-1994;112(10):142-146. View abstract.
- Koenen NJ, Haag RF Bia P Rose P. Perkutane therapie bei aktivierter Gonarthrose. Munch Med Wochenschr 1996;138:534e8.
- Kumar, S., Kumar, S., Ganesamoni, R., Mandal, A. K., Prasad, S., and Singh, S. K. Dimethyl sulfoxide with lignocaine versus eutectic mixture of local anesthetics: prospective randomized study to compare the efficacy of cutaneous anesthesia in shock wave lithotripsy. Urol.Res 2011;39(3):181-183. View abstract.
- Lawrence, H. J. and Goodnight, S. H., Jr. Dimethyl sulfoxide and extravasation of anthracycline agents. Ann.Intern.Med. 1983;98(6):1025. View abstract.
- Lawrence, H. J., Walsh, D., Zapotowski, K. A., Denham, A., Goodnight, S. H., and Gandara, D. R. Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation. Cancer Chemother.Pharmacol 1989;23(5):316-318. View abstract.
- Layman, D. L. and Jacob, S. W. The absorption, metabolism and excretion of dimethyl sulfoxide by rhesus monkeys. Life Sci 12-23-1985;37(25):2431-2437. View abstract.
- Lishner, M., Lang, R., Kedar, I., and Ravid, M. Treatment of diabetic perforating ulcers (mal perforant) with local dimethylsulfoxide. J.Am.Geriatr.Soc. 1985;33(1):41-43. View abstract.
- MacCallum, F. O. and Juel-Jensen, B. E. Herpes simplex virus skin infection in man treated with idoxuridine in dimethyl sulphoxide. Results of double-blind controlled trial. Br Med J 10-1-1966;2(5517):805-807. View abstract.
- Matsugasumi, T., Kamoi, K., Harikai, S., Inagaki, T., Kimura, Y., Hirahara, N., Sou, J., Nakagawa, S., Kawauchi, A., and Miki, T. [Localized amyloidosis of the urinary bladder: a case report]. Hinyokika Kiyo 2011;57(8):439-443. View abstract.
- Matsumoto, J. Clinical trials of dimethyl sulfoxide in rheumatoid arthritis patients in Japan. Ann.N.Y.Acad.Sci. 3-15-1967;141(1):560-568. View abstract.
- McCammon, K. A., Lentzner, A. N., Moriarty, R. P., and Schellhammer, P. F. Intravesical dimethyl sulfoxide for primary amyloidosis of the bladder. Urology 1998;52(6):1136-1138. View abstract.
- Nonoguchi, H., Kohda, Y., Fukutomi, R., Nakayama, Y., Naruse, M., Kitamura, K., Inoue, T., Nakanishi, T., and Tomita, K. A case with acute renal failure and subsequent nephrotic syndrome. Ren Fail. 2009;31(2):162-166. View abstract.
- Olver, I. N. and Schwarz, M. A. Use of dimethyl sulfoxide in limiting tissue damage caused by extravasation of doxorubicin. Cancer Treat.Rep. 1983;67(4):407-408. View abstract.
- Olver, I. N., Aisner, J., Hament, A., Buchanan, L., Bishop, J. F., and Kaplan, R. S. A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation. J.Clin Oncol. 1988;6(11):1732-1735. View abstract.
- Ozkaya-Bayazit, E., Kavak, A., Gungor, H., and Ozarmagan, G. Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis. Int.J.Dermatol. 1998;37(12):949-954. View abstract.
- Patel, S., Trivedi, A., Dholaria, P., Dholakia, M., Devra, A., Gupta, B., and Shah, S. A. Recurrent multifocal primary amyloidosis of urinary bladder. Saudi.J Kidney Dis Transpl. 2008;19(2):247-249. View abstract.
- Peeker, R., Haghsheno, M. A., Holmang, S., and Fall, M. Intravesical bacillus Calmette-Guerin and dimethyl sulfoxide for treatment of classic and nonulcer interstitial cystitis: a prospective, randomized double-blind study. J.Urol. 2000;164(6):1912-1915. View abstract.
- Perez, R. S., Zollinger, P. E., Dijkstra, P. U., Thomassen-Hilgersom, I. L., Zuurmond, W. W., Rosenbrand, K. C., and Geertzen, J. H. Evidence based guidelines for complex regional pain syndrome type 1. BMC.Neurol. 2010;10:20. View abstract.
- Perez, R. S., Zuurmond, W. W., Bezemer, P. D., Kuik, D. J., van loenen, A. C., de Lange, J. J., and Zuidhof, A. J. The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain 2003;102(3):297-307. View abstract.
- Perez-Marrero, R., Emerson, L. E., and Feltis, J. T. A controlled study of dimethyl sulfoxide in interstitial cystitis. J.Urol. 1988;140(1):36-39. View abstract.
- Ravid, M., Shapira, J., Lang, R., and Kedar, I. Prolonged dimethylsulphoxide treatment in 13 patients with systemic amyloidosis. Ann.Rheum.Dis. 1982;41(6):587-592. View abstract.
- Rigaud, J., Delavierre, D., Sibert, L., and Labat, J. J. [Specific treatments for painful bladder syndrome]. Prog.Urol. 2010;20(12):1044-1053. View abstract.
- Rossberger, J., Fall, M., and Peeker, R. Critical appraisal of dimethyl sulfoxide treatment for interstitial cystitis: discomfort, side-effects and treatment outcome. Scand.J Urol.Nephrol. 2005;39(1):73-77. View abstract.
- Sairanen, J., Leppilahti, M., Tammela, T. L., Paananen, I., Aaltomaa, S., Taari, K., and Ruutu, M. Evaluation of health-related quality of life in patients with painful bladder syndrome/interstitial cystitis and the impact of four treatments on it. Scand.J Urol.Nephrol. 2009;43(3):212-219. View abstract.
- Salim, A. S. A new approach to the treatment of nonsteroidal anti-inflammatory drugs induced gastric bleeding by free radical scavengers. Surg.Gynecol.Obstet. 1993;176(5):484-490. View abstract.
- Sea, J. and Teichman, J. M. Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment. Drugs 2009;69(3):279-296. View abstract.
- Shirley, H. H., Lundergan, M. K., Williams, H. J., and Spruance, S. L. Lack of ocular changes with dimethyl sulfoxide therapy of scleroderma. Pharmacotherapy 1989;9(3):165-168. View abstract.
- Sibert, L., Khalaf, A., Bugel, H., Sfaxi, M., and Grise, P. Intravesical dimethyl sulfoxide instillations can be useful in the symptomatic treatment of profuse hematuria due to eosinophilic cystitis. J.Urol. 2000;164(2):446. View abstract.
- Souza, C. S., Felicio, L. B., Ferreira, J., Kurachi, C., Bentley, M. V., Tedesco, A. C., and Bagnato, V. S. Long-term follow-up of topical 5-aminolaevulinic acid photodynamic therapy diode laser single session for non-melanoma skin cancer. Photodiagnosis.Photodyn.Ther 2009;6(3-4):207-213. View abstract.
- Stewart, B. H. and Shirley, S. W. Further experience with intravesical dimethyl sulfoxide in the treatment of interstitial cystitis. J.Urol. 1976;116(1):36-38. View abstract.
- Thiers, B. H. Unusual treatments for herpesvirus infections. II. Herpes zoster. J Am Acad.Dermatol 1983;8(3):433-436. View abstract.
- Tokunaka, S., Osanai, H., Morikawa, M., and Yachiku, S. Experience with dimethyl sulfoxide treatment for primary localized amyloidosis of the bladder. J.Urol. 1986;135(3):580-582. View abstract.
- Tran de, Q. H., Duong, S., Bertini, P., and Finlayson, R. J. Treatment of complex regional pain syndrome: a review of the evidence. Can J Anaesth. 2010;57(2):149-166. View abstract.
- van Dieten, H. E., Perez, R. S., van Tulder, M. W., de Lange, J. J., Zuurmond, W. W., Ader, H. J., Vondeling, H., and Boers, M. Cost effectiveness and cost utility of acetylcysteine versus dimethyl sulfoxide for reflex sympathetic dystrophy. Pharmacoeconomics. 2003;21(2):139-148. View abstract.
- Vuopala, U., Vesterinen, E., and Kaipainen, W. J. The analgetic action of dimethyl sulfoxide (DMSO) ointment in arthrosis. A double blind study. Acta Rheumatol.Scand. 1971;17(1):57-60. View abstract.
- Wang, W. J., Lin, C. S., and Wong, C. K. Response of systemic amyloidosis to dimethyl sulfoxide. J.Am.Acad.Dermatol. 1986;15(2 Pt 2):402-405. View abstract.
- Wengstrom, Y. and Margulies, A. European Oncology Nursing Society extravasation guidelines. Eur J Oncol.Nurs. 2008;12(4):357-361. View abstract.
- Yoshimitsu, K., Koga, N., Kitamura, Y., Fukuda, K., Kittaka, E., Horino, N., Sakura, N., Tanaka, T., Nishi, Y., Sakano, T., and . Favorable effect of dimethyl sulfoxide on secondary amyloidosis in juvenile rheumatoid arthritis. Pediatr.Pharmacol.(New York.) 1984;4(3):177-181. View abstract.
- Zuurmond, W. W., Langendijk, P. N., Bezemer, P. D., Brink, H. E., de Lange, J. J., and van loenen, A. C. Treatment of acute reflex sympathetic dystrophy with DMSO 50% in a fatty cream. Acta Anaesthesiol.Scand. 1996;40(3):364-367. View abstract.
- Barker SB, Matthews PN, Philip PF, Williams G. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59:142-4. View abstract.
- Bertelli G. Prevention and management of extravasation of cytotoxic drugs. Drug Saf 1995;12:245-55. View abstract.
- Birder LA, Kanai AJ, de Groat WC. DMSO: effect on bladder afferent neurons and nitric oxide release. J Urol 1997;158:1989-95. View abstract.
- Bookman AA, Williams KS, Shainhouse JZ. Effective of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004;171:333-8. View abstract.
- Brayton CF. Dimethyl sulfoxide (DMSO): a review. Cornell Vet 1986;76:61-90. View abstract.
- Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med 2009 May 27. [Epub ahead of print]. View abstract.
- Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6. View abstract.
- Capriotti K, Capriotti JA. Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology. J Clin Aesthet Dermatol. 2012;5(9):24-6. View abstract.
- Clinoril (sulindac) prescribing information. Merck & Co., Inc., Whitehouse Station, NJ, 2005. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/017911s074lbl.pdf. Accessed 7/27/2020.
- de la Torre JC. Role of dimethyl sulfoxide in prostaglandin-thromboxane and platelet systems after cerebral ischemia. Ann N Y Acad Sci 1983;411:293-308. View abstract.
- DOMOSO SOLUTION (90% Dimethyl Sulfoxide). Fort Dodge Animal Health, Fort Dodge, Iowa. Avaliable at: https://www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/domoso_solution_pi.pdf. Accessed 8/3/2020.
- Dorr RT. Antidotes to vesicant chemotherapy extravasations. Blood Rev 1990;4:41-60. View abstract.
- Eberhardt R, Zwingers T, Hoffman R. [DMSO in patients with active gonarthrosis. A double-blind placebo controlled phase III study]. Fortschr Med 1995;446:50. View abstract.
- Evans MS, Reid KH, Sharp JB Jr. Dimethylsuloxide (DMSO) blocks conduction in peripheral nerve C fibers: a possible mechanism of analgesia. Neurosci Lett 1993;150:145-8. View abstract.
- Fowler JE Jr. Prospective study of intravesical dimthyl sulfoxide in treatment of suspected early interstitial cystitis. Urology 1981;18:21-6. View abstract.
- Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, Goldlust IS, Hoeschele JD, Gottesman MM. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014 Jul 15;74(14):3913-22. doi: 10.1158/0008-5472.CAN-14-0247. View abstract.
- Hucker HB, Ahmad PM, Miller EA, et al. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature 1966;209:619-20.
- Jacob SW, Herschler R. Pharmacology of DMSO. Cryobiology 1986;23:14-27. View abstract.
- Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80.
- Karaca M, Bilgin UY, Akar M, de la Torre JC. Dimethyl sulphoxide lowers ICP after head trauma. Eur J Clin Pharmacol 1991;40:113-4. View abstract.
- Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 1997;73:123-39. View abstract.
- Ludwig CU, Stoll HR, Obrist R, Obrecht JP. Prevention of cytotoxic drug induced skin ulcers with dimethyl sulfoxide (DMSO) and alpha-tocopherol. Eur J Cancer Clin Oncol 1987;23:327-9. View abstract.
- MacCallum FO, Juel-Jensen BE. Herpes simplex virus skin infection in man treated with idoxuridine in dimethyl sulphoxide. Results of double-blind controlled trial. Br Med J 1966;2:805-7.
- Marshall LF, Camp PE, Bowers SA. Dimethyl sulfoxide for the treatment of intracranial hypertension: a preliminary trial. Neurosurg 1984;14:659-63. View abstract.
- Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
- Neulieb RL, Neulieb MK. The diverse actions of dimtheyl sulphoxide: an indicator of membrane transport activity. Cytobios 1990;63:139-65. View abstract.
- Prior D, Mitchell A, Nebauer M, Smith M. Oncology nurses' experience of dimethyl sulfoxide odor. Cancer Nurs 2000;23:134-40. View abstract.
- Rand-Luby L, Pommier RF, Williams ST, et al. Improved outcome of surgical flaps treated with topical dimethylsulfoxide. Ann Surg 1996;224:583-9. View abstract.
- Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. View abstract.
- Rowley SD. Hematopoietic stem cell processing and cryopreservation. J Clin Apheresis 1992;7:132-4. View abstract.
- Rubin LF. Toxicologic update of dimethyl sulfoxide. Ann N Y Acad Sci 1983;411:6-10.
- Salim AS. The relationship between Helicobacter pylori and oxygen-derived free radicals in the mechanism of duodenal ulceration. Intern Med 1993;32:359-64. View abstract.
- Sant GR, LaRock DR. Standard intravesical therapies for interstial cystitis. Urol Clin North Am 1994;21:73-83. View abstract.
- Sant GR. Intravesical 50% dimethyl sulfoxide (Rimso-50) in treatment of interstitial cystitis. Urology 1987;29:17-21.
- Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 1978;11:215-20. View abstract.
- Simon LS, Grierson LM, Naseer Z, et al. Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. Pain 2009;143:238-45. View abstract.
- Spremulli EN, Dexter DL. Polar solvents: a novel class of antineoplastic agents. J Clin Oncol 1984;2:227-41. View abstract.
- Takacs T, Montet JC. In vitro dissolution of cholesterol biliary stones. Gut 1995;37:157-8.
- Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6.
- Toren A, Rechavi G. What really cures in autologous bone marrow transplantation? A possible role for dimethylsulfoxide. Med Hypotheses 1993;41:495-8. View abstract.
- Torres MA, Furst DE. Treatment of generalized systemic sclerosis. Rheum Dis Clin North Am 1990;16:217-41. View abstract.
- Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60.
- Visudyne (verteporfin) prescribing information. JHP Pharmaceuticals, LLC, Rochester, MI, 2016. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021119s027lbl.pdf. Accessed 7/27/2020.
- Wildenhoff KE, Esmann V, Ipsen J, Harving H, et al. Treatment of trigeminal and thoracic zoster with idoxuridine. Scand J Infect Dis 1981;13:257-62. View abstract.
- Williams HJ, Furst DE, Dahl SL, et al. Double-blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis. Arthritis Rheum 1985;28:308-14. View abstract.
- Wolf P, Simon M. Dimethyl sulphoxide (DMSO) induced serum hyperosmolality. Clin Biochem 1983;16:261-2. View abstract.
- Zambelli A, Poggi G, Da Prada G, et al. Clinical toxicity of cryopreserved circulation progenitor cells infusion. Anticancer Res 1998;18:4705-8. View abstract.
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