PRICKLY PEAR CACTUS

OTHER NAME(S):

Barbary Fig, Cactus decumanus, Cactus ficus-indica, Cactus Flowers, Cactus Fruit, Cactus Pear Fruit, Figue d'Inde, Figuier de Barbarie, Fruit du Cactus, Fruit de l'Oponce, Indian Fig, Indian Fig Prickly Pear, Indien Figue, Nopal, Nopal Cactus, Nopales, Nopol, OPI, Oponce, Opuntia, Opuntia albicarpa, Opuntia amyclaea, Opuntia cordobensis, Opuntia decumana, Opuntia ficus, Opuntia ficus-barbarica, Opuntia ficus-indica, Opuntia gymnocarpa, Opuntia hispanica, Opuntia joconostle, Opuntia maxima, Opuntia megacantha, Opuntia paraguayensis, Prickly Pear, Spineless Cactus, Tuna Cactus.<br/><br/>

Overview

Overview Information

Prickly pear cactus is a plant. It is part of the diet in Mexican and Mexican-American cultures and is also used for medicine.

Prickly pear cactus is most commonly used for diabetes.

How does it work?

Prickly pear cactus might lower blood sugar levels and cholesterol levels by decreasing the absorption of sugar and cholesterol in the stomach and intestine.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. Single doses of prickly pear cactus can decrease blood sugar levels by 17% to 48% in some people. It is not known if extended daily use can consistently lower blood sugar levels.

Insufficient Evidence for

  • Enlarged prostate. Early research shows that taking powdered prickly pear cactus flowers may reduce symptoms of enlarged prostate such as urges to urinate or feeling like the bladder is full.
  • Inherited high cholesterol (familial hypercholesterolemia). Early research shows that taking edible pulp of prickly pear cactus daily for 4 weeks while following a recommended diet reduces total and low-density lipoprotein (LDL or "bad") cholesterol levels in people with inherited high cholesterol.
  • Hangover. Taking prickly pear cactus extract before drinking alcohol might reduce some symptoms of hangover the next day. It seems to reduce symptoms such as nausea, anorexia, and dry mouth. However, it does not seem to reduce symptoms such as headache, dizziness, diarrhea, or soreness.
  • High cholesterol (hypercholesterolemia). Early research shows that taking prickly pear cactus daily, while following a diet, can reduce total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and triglyceride levels in people with high cholesterol. High-density lipoprotein (HDL or "good") cholesterol levels do not seem to be affected.
  • Metabolic syndrome. Early research shows that taking a specific product derived from prickly pear cactus leaves for 6 weeks does not reduce blood fats in women with metabolic syndrome.
  • Weight loss. Research shows that prickly pear cactus does not reduce body weight in patients who are normal weight or overweight.
  • Colitis.
  • Diarrhea.
  • Treating infections caused by viruses.
  • Other conditions.
More evidence is needed to rate the effectiveness of prickly pear cactus for these uses.

Side Effects

Side Effects & Safety

Prickly pear cactus is LIKELY SAFE when eaten as food. The leaves, stems, flowers, fruit and standardized extracts of the prickly pear cactus are POSSIBLY SAFE when taken by mouth as medicine in appropriate amounts for a short period of time. In some people, prickly pear cactus can cause some minor side effects including diarrhea, nausea, increased amount and frequency of stool, bloating, and headache. In rare cases, eating large amounts of prickly pear cactus fruits can cause a blockage in the lower intestines.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking prickly pear cactus if you are pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Diabetes: Prickly pear cactus might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use prickly pear cactus.

Surgery: Prickly pear cactus might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using prickly pear cactus at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Chlorpropamide (Diabinese) interacts with PRICKLY PEAR CACTUS

    Chlorpropamide (Diabinese) is used to decrease blood sugar in people with diabetes. Prickly pear cactus might also decrease blood sugar. Taking prickly pear cactus along with chlorpropamide (Diabinese) might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your chlorpropamide (Diabinese) might need to be changed.

  • Glyburide (Diabeta, Micronase) interacts with PRICKLY PEAR CACTUS

    Glyburide (Diabeta, Micronase) is used to decrease blood sugar in people with diabetes. Prickly pear cactus might also decrease blood sugar. Taking prickly pear cactus along with glyburide (Diabeta, Micronase) might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of glyburide (Diabeta, Micronase) might need to be changed.

  • Medications for diabetes (Antidiabetes drugs) interacts with PRICKLY PEAR CACTUS

    Prickly pear cactus can decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking prickly pear cactus along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br/><br/> Some medications used for diabetes include glimepiride (Amaryl), insulin, pioglitazone (Actos), rosiglitazone (Avandia), glipizide (Glucotrol), tolbutamide (Orinase), and others.

  • Metformin (Glucophage) interacts with PRICKLY PEAR CACTUS

    Metformin (Glucophage) is used to decrease blood sugar in people with diabetes. Prickly pear cactus might also decrease blood sugar. Taking prickly pear cactus along with metformin (Glucophage) might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your metformin (Glucophage) might need to be changed.

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

  • For diabetes: 300 grams of steamed prickly pear cactus pad and 500 grams of broiled stems of prickly pear cactus have been taken as a single dose.

View References

REFERENCES:

  • Bouslama, L., Hayashi, K., Lee, J. B., Ghorbel, A., and Hayashi, T. Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses. J.Nat.Med. 2011;65(1):229-233. View abstract.
  • Budinsky, A., Wolfram, R., Oguogho, A., Efthimiou, Y., Stamatopoulos, Y., and Sinzinger, H. Regular ingestion of opuntia robusta lowers oxidation injury. Prostaglandins Leukot.Essent.Fatty Acids 2001;65(1):45-50. View abstract.
  • de, Wit M., Nel, P., Osthoff, G., and Labuschagne, M. T. The effect of variety and location on cactus pear (Opuntia ficus-indica) fruit quality. Plant Foods Hum.Nutr. 2010;65(2):136-145. View abstract.
  • Ennouri, M., Fetoui, H., Bourret, E., Zeghal, N., and Attia, H. Evaluation of some biological parameters of Opuntia ficus indica. 1. Influence of a seed oil supplemented diet on rats. Bioresour.Technol. 2006;97(12):1382-1386. View abstract.
  • Ennouri, M., Fetoui, H., Bourret, E., Zeghal, N., Guermazi, F., and Attia, H. Evaluation of some biological parameters of Opuntia ficus indica. 2. Influence of seed supplemented diet on rats. Bioresour.Technol. 2006;97(16):2136-2140. View abstract.
  • Fernandez, M. L., Lin, E. C., Trejo, A., and McNamara, D. J. Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs. J Nutr 1992;122(12):2330-2340. View abstract.
  • Fernandez, M. L., Trejo, A., and McNamara, D. J. Pectin isolated from prickly pear (Opuntia sp.) modifies low density lipoprotein metabolism in cholesterol-fed guinea pigs. J Nutr 1990;120(11):1283-1290. View abstract.
  • Frati AC, Jimenex E Aruza R. Hypoglycemic effect of Opuntia ficus indica in non-insulin dependent diabetes mellitus patients. Phytother Res 1990;4(5):195-197.
  • Frati, A. C., Gordillo, B. E., Altamirano, P., Ariza, C. R., Cortes-Franco, R., Chavez-Negrete, A., and Islas-Andrade, S. Influence of nopal intake upon fasting glycemia in type II diabetics and healthy subjects. Arch Invest Med (Mex.) 1991;22(1):51-56. View abstract.
  • Frati-Munari, A. C., de Leon, C., Ariza-Andraca, R., Banales-Ham, M. B., Lopez-Ledesma, R., and Lozoya, X. [Effect of a dehydrated extract of nopal (Opuntia ficus indica Mill.) on blood glucose]. Arch.Invest Med.(Mex.) 1989;20(3):211-216. View abstract.
  • Frati-Munari, A. C., Fernandez-Harp, J. A., Banales-Ham, M., and Ariza-Andraca, C. R. Decreased blood glucose and insulin by nopal (Opuntia sp.). Arch Invest Med (Mex.) 1983;14(3):269-274. View abstract.
  • Frati-Munari, A. C., Fernandez-Harp, J. A., de la, Riva H., Ariza-Andraca, R., and del Carmen, Torres M. Effects of nopal (Opuntia sp.) on serum lipids, glycemia and body weight. Arch Invest Med (Mex.) 1983;14(2):117-125. View abstract.
  • Frati-Munari, A. C., Rios, Gil U., Ariza-Andraca, C. R., Islas, Andrade S., and Lopez, Ledesma R. [Duration of the hypoglycemic action of Opuntia streptacantha Lem.]. Arch Invest Med (Mex.) 1989;20(4):297-300. View abstract.
  • Galati, E. M., Mondello, M. R., Lauriano, E. R., Taviano, M. F., Galluzzo, M., and Miceli, N. Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. Phytother Res 2005;19(9):796-800. View abstract.
  • Godard, M. P., Ewing, B. A., Pischel, I., Ziegler, A., Benedek, B., and Feistel, B. Acute blood glucose lowering effects and long-term safety of OpunDia supplementation in pre-diabetic males and females. J.Ethnopharmacol. 8-9-2010;130(3):631-634. View abstract.
  • Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607. View abstract.
  • Laurenz, J. C., Collier, C. C., and Kuti, J. O. Hypoglycaemic effect of Opuntia lindheimeri Englem in a diabetic pig model. Phytother Res 2003;17(1):26-29. View abstract.
  • Li, C. Y., Cheng, X. S., Cui, M. Z., and Yan, Y. G. [Regulative effect of Opuntia powder on blood lipids in rats and its mechanism]. Zhongguo Zhong.Yao Za Zhi. 2005;30(9):694-696. View abstract.
  • Lim, K. T. Inhibitory effect of glycoprotein isolated from Opuntia ficus-indica var. saboten MAKINO on activities of allergy-mediators in compound 48/80-stimulated mast cells. Cell Immunol. 2010;264(1):78-85. View abstract.
  • Linares, E., Thimonier, C., and Degre, M. The effect of NeOpuntia on blood lipid parameters--risk factors for the metabolic syndrome (syndrome X). Adv.Ther. 2007;24(5):1115-1125. View abstract.
  • Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118. View abstract.
  • Palumbo, B., Efthimiou, Y., Stamatopoulos, J., Oguogho, A., Budinsky, A., Palumbo, R., and Sinzinger, H. Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia. Nucl.Med Rev Cent.East Eur 2003;6(1):35-39. View abstract.
  • Pittler, M. H., Verster, J. C., and Ernst, E. Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials. BMJ 12-24-2005;331(7531):1515-1518. View abstract.
  • Sanchez, E., Garcia, S., and Heredia, N. Extracts of edible and medicinal plants damage membranes of Vibrio cholerae. Appl.Environ.Microbiol. 2010;76(20):6888-6894. View abstract.
  • Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. View abstract.
  • Tesoriere L, Allegra M Butera D et al. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: Potential health effects of betalains in humans. Am J Clin Nutr 2004;80:941-945.
  • Wolfram, R. M., Kritz, H., Efthimiou, Y., Stomatopoulos, J., and Sinzinger, H. Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia--a pilot study. Wien.Klin.Wochenschr. 10-31-2002;114(19-20):840-846. View abstract.
  • Ahmad A, Davies J, Randall S, Skinner GR. Antiviral properties of extract of Opuntia streptacantha. Antiviral Res 1996;30:75-85. View abstract.
  • Argaez-Lopez N, Wacher NH, Kumate-Rodriguez J, et al. The use of complementary and alternative medicine therapies in type 2 diabetic patients in Mexico. Diabetes Care 2003;26:2470-1. View abstract.
  • Bacardi-Gascon M, Duenas-Mena D, Jimenez-Cruz A. Lowering effect on postprandial glycemic response of nopales added to Mexican breakfasts. Diabetes Care 2007;30:1264-5. View abstract.
  • Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5. View abstract.
  • Fernandez ML, Lin EC, Trejo A, McNamara DJ. Prickly pear (Opuntia sp.) pectin alters hepatic cholesterol metabolism without affecting cholesterol absorption in guinea pigs fed a hypercholesterolemic diet. J Nutr 1994;124:817-24. View abstract.
  • Frati AC, Xilotl Diaz N, Altamirano P, et al. The effect of two sequential doses of Opuntia streptacantha upon glycemia. Arch Invest Med (Mex) 1991;22:333-6. View abstract.
  • Frati Munari AC, Quiroz Lazaro JL, Alramirano Bustamante P, et al. The effect of various doses of nopal (Opuntia streptacantha Lemaire) on the glucose tolerance test in healthy individuals. Arch Invest Med (Mex) 1988;19:143-8.
  • Frati Munari AC, Vera Lastra O, Ariza Andraca CR. Evaluation of nopol capsules in diabetes mellitus. Gac Med Mex 1992;128:431-6. View abstract.
  • Frati-Munari AC, Altamirano-Bustamante E, Rodríguez-Bárcenas N, et al. Hypoglycemic action of Opuntia streptacantha Lemaire: study using raw extracts. Arch Invest Med (Mex) 1989;20:321-5. View abstract.
  • Frati-Munari AC, Del Valle-Martinez LM, Ariza-Andraca CR, et al. Hypoglycemic action of different doses of nopal (Opuntia streptacantha Lemaire) in patients with type II diabetes mellitus. Arch Invest Med (Mex) 1989;20:197-201. View abstract.
  • Frati-Munari AC, Gordillo BE, Altamirano P, Ariza CR. Hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 1988;11:63-6. View abstract.
  • Frati-Munari AC, Licona-Quesada R, Araiza-Andraca CR, et al. Activity of Opuntia streptocantha in healthy individuals with induced hyperglycemia. Arch Invest Med (Mex) 1990;21:99-102. View abstract.
  • Frati-Munari AC, Roca-Vides RA, Lopez-Perez RJ, et al. The glycemic index of some foods common in Mexico. Gac Med Mex 1991;127:163-70. View abstract.
  • López-Romero P, Pichardo-Ontiveros E, Avila-Nava A, Vázquez-Manjarrez N, Tovar AR, Pedraza-Chaverri J, et al. The effect of Nopal (Opuntia Ficus Indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J Acad Nutr Diet. 2014;114(11):1811-8. View abstract.
  • Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  • Newcomer AD, Park HS, O'Brien PC, McGill DB. Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. Am J Clin Nutr 1983;38:257-63. View abstract.
  • Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. View abstract.
  • Palevitch D, Earon G, Levin I. Treatment of benign prostatic hypertrophy with Opuntia ficus-indica (L.) Miller. Int J Comp Alt Med 1994;Sept:21-2.
  • Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  • Roman-Ramos R, Flores-Saenz JL, Alarcon-Aguilar FJ. Anti-hyperglycemic effect of some edible plants. J Ethnopharmacol 1995;48:25-32. View abstract.
  • Roman-Ramos R, Flores-Saenz JL, Partida-Hernandez G, et al. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch Invest Med (Mex) 1991;22:87-93. View abstract.
  • Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. View abstract.
  • Tesoriere L, Butera D, Pintaudi AM, et al. Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am J Clin Nutr 2004;80:391-5. View abstract.
  • Trejo-Gonzalez A, Gabriel-Ortiz G, Puebla-Perez A, et al. A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats. J Ethnopharmacol 1996;55:27-33. View abstract.
  • Wiese J, McPherson S, Odden MC, Shlipak MG. Effect of Opuntia ficus indica on symptoms of the alcohol hangover. Arch Intern Med 2004;164:1334-40. View abstract.
  • Wolfram R, Budinsky A, Efthimiou Y, et al. Daily prickly pear consumption improves platelet function. Prostaglandins Leukot Essent Fatty Acids 2003;69:61-6. View abstract.

More Resources for PRICKLY PEAR CACTUS

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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