BAIKAL SKULLCAP

OTHER NAME(S):

Baikal Scullcap, Baikal Skullcap Root, Chinese Skullcap, Chinesisches Helmkraut, Escutelaria Asiatica, Huang Qin, Huangquin, Hwanggum, Ogon, Ou-gon, Praktfrossort, Racine de Scutellaire du Lac Baïkal, Radix Scutellariae, Scullcap, Scute, Scutellaire, Scutellaire Chinoise, Scutellaire du Lac Baïkal, Scutellaria, Scutellaria baicalensis, Scutellaria macrantha, Scutellariae Radix, Skullcap, Wogon.

Overview

Overview Information

Baikal skullcap is a plant. The root is used to make medicine. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii.

Baikal skullcap is used for respiratory infections, gastrointestinal (GI) infections, liver problems, swelling (inflammation), and many other conditions, but there is no good scientific evidence to support any uses.

How does it work?

It is thought that the active chemicals in Baikal skullcap might be able to decrease inflammation, stop tumor growth, and prevent tumor cell reproduction.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Swelling (inflammation) of small airways in the lung (bronchiolitis). Early research shows that a combination of Baikal skullcap, forsythia, and honeysuckle given intravenously (IV) by a healthcare provider might help children who have bronchiolitis due to respiratory syncytial virus (RSV) infection feel better faster.
  • Diabetes. Early research shows that taking Baikal skullcap doesn't improve fasting blood sugar levels in people with diabetes that is not controlled with metformin. But it might reduce levels of blood sugar after a meal by a small amount.
  • Hand, foot, and mouth disease. Early research found that some children with severe hand, foot, and mouth disease who are given Baikal skullcap intravenously (by IV) in combination with other herbs feel better faster compared to those given an antiviral medicine called ribavirin.
  • Osteoarthritis. Some research shows that a specific commercial product (Limbrel, Primus Pharmaceuticals) that contains a combination of chemicals from Baikal skullcap and catechu, also known as flavocoxid, might help for arthritis in the knee. But there is not enough good quality research to know how well this product might work.
  • Scaly, itchy skin (psoriasis). Early research shows that applying an ointment containing Baikal skullcap, phellodendron, and isatis to the skin might improve symptoms in children with psoriasis that does not respond to other treatment.
  • Atherosclerosis.
  • Bitter taste in the mouth.
  • Fever.
  • Flushed face.
  • Hay fever.
  • Headache.
  • Hemorrhoids.
  • Hepatitis.
  • HIV/AIDS.
  • Insomnia.
  • Kidney, stomach, and pelvic infections.
  • Nervous tension.
  • Prostate cancer.
  • Red eyes.
  • Seizures.
  • Sores or swelling.
  • Other conditions.
More evidence is needed to rate Baikal skullcap for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. It might cause drowsiness. There have been reports of fever and lung inflammation in people who took Baikal skullcap. But there is not enough information to know if Baikal skullcap is the cause of these side effects.

There are also concerns that some products containing Baikal skullcap might cause liver problems in some people. A specific combination product called flavocoxid (Limbrel, Primus Pharmaceuticals), was safely used in research studies lasting up to 12 weeks. However, there are concerns that this combination product or others might cause liver problems in some people. This side effect does not appear to be common and might only occur in people who have a type of allergic reaction to it.

When applied to the skin: There isn't enough reliable information to know if Baikal skullcap is safe or what the side effects might be.

When given by IV: There isn't enough reliable information to know if Baikal skullcap is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if Baikal skullcap is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders. Baikal skullcap might slow blood clotting. In theory, Baikal skullcap might increase the risk of bruising and bleeding in people with bleeding disorders.

Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use Baikal skullcap.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Baikal skullcap might have the same effects as the female hormone estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal.

Low blood pressure: Baikal skullcap might lower blood pressure. In theory, Baikal skullcap might lower blood pressure too much in people prone to low blood pressure.

Surgery: Baikal skullcap might slow blood clotting. There is concern that it might cause extra bleeding during and after surgery. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Alcohol interacts with BAIKAL SKULLCAP

    Alcohol can cause sleepiness and drowsiness. Baikal skullcap might also cause sleepiness and drowsiness. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness.

  • Lithium interacts with BAIKAL SKULLCAP

    Baikal skullcap might have an effect like a water pill or "diuretic." Taking Baikal skullcap might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

  • Medications for diabetes (Antidiabetes drugs) interacts with BAIKAL SKULLCAP

    Baikal skullcap might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

  • Sedative medications (Benzodiazepines) interacts with BAIKAL SKULLCAP

    Baikal skullcap might cause sleepiness and drowsiness. Medications that cause sleepiness and drowsiness are called sedatives. Taking Baikal skullcap along with sedative medications might cause too much sleepiness.

    Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.

  • Sedative medications (CNS depressants) interacts with BAIKAL SKULLCAP

    Baikal skullcap might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking Baikal skullcap along with sedative medications might cause too much sleepiness.

    Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Minor Interaction

Be watchful with this combination

!
  • Medications used for lowering cholesterol (Statins) interacts with BAIKAL SKULLCAP

    Baikal skullcap might change the levels of statins in your blood. But there isn't enough information to know if this is an important interaction. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol.

    These medications include atorvastatin (Lipitor), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and simvastatin (Zocor).

Dosing

Dosing

The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Baikal skullcap. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood 2-15-2008;111(4):2354-2363. View abstract.
  • Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother.Res 2003;17(6):640-644. View abstract.
  • Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 5-15-2005;11(10):3905-3914. View abstract.
  • Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett. 11-28-2000;160(2):219-228. View abstract.
  • Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 5-17-2011;135(2):359-368. View abstract.
  • Chang, W. H., Chen, C. H., and Lu, F. J. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Med 2002;68(2):128-132. View abstract.
  • Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. View abstract.
  • Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology 5-2-2009;259(1-2):10-17. View abstract.
  • Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. In Vivo 2004;18(4):497-503. View abstract.
  • Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. View abstract.
  • Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. View abstract.
  • Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS.Neurol.Disord Drug Targets. 2011;10(2):184-191. View abstract.
  • Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. J Nat Prod 2009;72(9):1616-1619. View abstract.
  • Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin. 2009;30(11):1505-1512. View abstract.
  • Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett. 1-8-2007;245(1-2):269-274. View abstract.
  • Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Biomed.Chromatogr. 1997;11(3):125-131. View abstract.
  • Hong, T., Jeong, M. L., Zahn, M., Fay, B. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. J AOAC Int 2009;92(3):785-788. View abstract.
  • Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Planta Med 2011;77(5):455-460. View abstract.
  • Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Planta Med 2000;66(8):694-698. View abstract.
  • Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Phytomedicine. 2010;17(1):47-54. View abstract.
  • Huang, W. M., Yan, J., and Xu, J. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(8):465-467. View abstract.
  • Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Biological properties of baicalein in cardiovascular system. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. View abstract.
  • Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. J Cell Biochem 10-1-2010;111(2):274-283. View abstract.
  • Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Nat Prod Res 2008;22(16):1410-1412. View abstract.
  • Kaplya, O. A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Bull Exp Biol Med 2004;137(5):471-474. View abstract.
  • Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Planta Med 2001;67(5):396-399. View abstract.
  • Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Planta Med 2010;76(7):678-682. View abstract.
  • Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk.Res 2007;31(4):523-530. View abstract.
  • Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Biol Pharm Bull 2003;26(1):79-83. View abstract.
  • Lam, T. L., Lam, M. L., Au, T. K., Ip, D. T., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. Life Sci 10-27-2000;67(23):2889-2896. View abstract.
  • Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Ann N Y Acad Sci 2007;1095:521-526. View abstract.
  • Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. J Med Chem 10-21-2004;47(22):5555-5566. View abstract.
  • Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food Chem Toxicol. 2007;45(3):403-411. View abstract.
  • Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. View abstract.
  • Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. Cell Mol Biol Res 1993;39(2):119-124. View abstract.
  • Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology 3-4-2009;257(1-2):80-85. View abstract.
  • Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Eur J Drug Metab Pharmacokinet. 6-29-2011; View abstract.
  • Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. J Ethnopharmacol. 4-12-2011;134(3):884-891. View abstract.
  • Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Int J Cancer 9-10-2003;106(4):559-565. View abstract.
  • Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. Eur J Haematol. 2-1-2010;84(2):137-144. View abstract.
  • Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Cancer Lett. 11-1-2009;284(2):198-207. View abstract.
  • Martin, J. and Dusek, J. [The Baikal scullcap (Scutellaria baicalensis Georgi)--a potential source of new drugs]. Ceska.Slov.Farm. 2002;51(6):277-283. View abstract.
  • Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Journal of medicinal food 2009;12(5):1143-8.
  • Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol Biochem Behav 2009;92(4):642-648. View abstract.
  • Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. Mol Urol. 2000;4(3):289-291. View abstract.
  • Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Vopr.Onkol. 1989;35(3):331-335. View abstract.
  • Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. Eksp.Klin Farmakol. 1998;61(2):54-56. View abstract.
  • Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Nahrung 2004;48(2):123-128. View abstract.
  • Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern.Ther.Health Med. 2010;16(2):32-40. View abstract.
  • Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. BMC.Complement Altern Med 2006;6:27. View abstract.
  • Shang, Y. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. Indian J Med Res 2008;127(6):610-615. View abstract.
  • Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Am J Chin Med 2006;34(2):245-261. View abstract.
  • Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. J Biomed.Sci 2009;16:27. View abstract.
  • Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. View abstract.
  • Tian, X. Y., Cheung, L. M., Leung, K., Qi, C., Deng, B., Deng, P. X., and Xu, M. The effects of Scutellaria baicalensis extract on embryonic development in mice. Birth Defects Res B Dev.Reprod.Toxicol. 2009;86(2):79-84. View abstract.
  • Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Vopr.Onkol. 1990;36(5):602-607. View abstract.
  • Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Am J Chin Med 2008;36(3):517-540. View abstract.
  • Wang R.T, Zhang J.X, and Dong Y.J. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection Aß25-35. Chinese Journal of Gerontology 2010;30(7):926-928.
  • Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int J Mol Med 2004;14(4):627-632. View abstract.
  • Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Invest New Drugs 2011;29(4):637-645. View abstract.
  • Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Cancer Lett. 7-28-2004;211(1):39-46. View abstract.
  • Ye, F., Xui, L., Yi, J., Zhang, W., and Zhang, D. Y. Anticancer activity of Scutellaria baicalensis and its potential mechanism. J Altern Complement Med 2002;8(5):567-572. View abstract.
  • Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. Food Chem Toxicol. 2010;48(5):1202-1209. View abstract.
  • You, C. L., Su, P. Q., and Zhou, X. X. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. View abstract.
  • You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. J Chromatogr.A 3-19-2010;1217(12):1875-1881. View abstract.
  • Yuan Y., Liu Y.J, Luo Y.J, and et al. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. African Journal of Biotechnology 2011;10(26):5182-5192.
  • Zhang H and Huang J. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9.
  • Zhang S, Cheng Z, Huang B, and Li J. The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients. Journal of Chinese medicinal materials 2002;25(6):451-453.
  • Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res 7-15-2003;63(14):4037-4043. View abstract.
  • Altavilla D, Squadrito F, Bitto A, et al. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Br J Pharmacol 2009;157:1410-18. View abstract.
  • Arjmandi BH, Ormsbee LT, Elam ML, et al. A combination of Scutellaria baicalensis and Acacia catechu for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the knee. J Med Food 2014;17(6):707-13. View abstract.
  • Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Seattle, WA: Eastland Press 1996:107-8.
  • Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. Phytother Res 2000;14:210-2. View abstract.
  • Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). Intern Med J. 2019;49(4):544-546. View abstract.
  • Burnett BP, Jia Q, Zhao Y, Levy RM. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food 2007;10:442-51. View abstract.
  • Chalasani N, Vuppalanchi R, Navarro V, et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med 2012;156:857-60. View abstract.
  • Chen C, Mireles RJ, Campbell SD, et al. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005;33:537-46. View abstract.
  • Chou TC, Chang LP, Li CY, et al. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Anesth Analg 2003;97:1724-9. View abstract.
  • Fan L, Zhang W, Guo D, et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Clin Pharmacol Ther 2007;83:471-6. View abstract.
  • Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1999;1472:643-50. View abstract.
  • Gol'dberg VE, Ryzhakov VM, Matiash MG, et al. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. Eksp Klin Farmakol 1997;60:28-30. View abstract.
  • Huang KC. The pharmacology of Chinese herbs. 2nd ed. New York, NY: CRC Press LLC. 1999;385-6, 400-1.
  • Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med 2000;66:91-3. View abstract.
  • Jin BR, Chung KS, Kim HJ, An HJ. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. J Ethnopharmacol. 2019;235:481-488. View abstract.
  • Kim M, Lee BC. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Evid Based Complement Alternat Med. 2019;2019:3239649. View abstract.
  • Kong XT, Fang HT, Jiang GQ, et al. Treatment of acute bronchiolitis with Chinese herbs. Arch Dis Child 1993;68:468-71. View abstract.
  • Konig J, Seithel A, Gradhand U, Fromm MF. Pharmacogenomics of human OATP transporters. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. View abstract.
  • Lee BH, Lee SJ, Kang TH, et al. Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis. Planta Med 2000;66:70-1. View abstract.
  • Levy RM, Khokhlov A, Kopenkin S, et al. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Adv Ther 2010;27:731-42. View abstract.
  • Levy RM, Saikovsky R, Shmidt E, et al. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Nutr Res 2009;29:298-304. View abstract.
  • Li BQ, Fu T, Gong WH, et al. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 2000;49:295-306. View abstract.
  • Liao JF, Wang HH, Chen MC, et al. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med 1998;64:571-2. View abstract.
  • Lin H, Zhou J, Lin K, et al. Efficacy of Scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with EV71: a multicenter, retrospective analysis. Biomed Res Int 2016;2016:5697571. View abstract.
  • Lin YK, Yen HR, Wong WR, et al. Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. Pediatr Dermatol 2006;23:507-10. View abstract.
  • Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. View abstract.
  • Morgan SL, Baggott JE, Moreland L, et al. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. J Med Food 2009;12:1143-8. View abstract.
  • Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 1998;61:1413-5. View abstract.
  • Orzechowska B, Chaber R, Wisniewska A, et al. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. Int Immunopharmacol 2014;23(2):558-67. View abstract.
  • Papafragkakis C, Ona MA, Reddy M, Anand S. Acute hepatitis after ingestion of a preparation of Chinese skullcap and black catechu for joint pain. Case Reports Heptal 2016;2016:4356749. View abstract.
  • Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther 2007;82:726-33. View abstract.
  • PC-SPES (PDQ) - Health Professional Version. NIH National Cancer Institute. Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. Accessed Sept 30, 2016.
  • PL-Detail Document, Liver Toxicity and Limbrel. Pharmacist's Letter/Prescriber's Letter. September 2012.
  • Puri BK, White N, Monro JA. The effect of supplementation with Scutellaria baicalensis on hepatic function. Med Hypotheses. 2019;133:109402. View abstract.
  • Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Ann Intern Med 2012;156:894-5. View abstract.
  • Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. Am J Physiol Endocrinol Metab. 2020;318(1):E52-E61. View abstract.
  • Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Eksp Klin Farmakol 1997;60:49-51. View abstract.
  • Takeshita K, Saisho Y, Kitamura K, et al. Pneumonitis induced by ou-gon (scullcap). Intern Med 2001;40:764-8. View abstract.
  • Wu X, Zhang H, Salmani JM, et al. Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. Onco Targets Ther 2016;9:2935-43. View abstract.
  • Ye F, Wang H, Jiang S, et al. Quality evaluation of commercial extracts of Scutellaria baicalensis. Nutr Cancer 2004;49(2):217-22. View abstract.
  • Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract.
  • Zhang H, Huang J. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260. View abstract.
  • Zhou J, Qu F, Yu Y, et al. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? Afr J Tradit Complement Altern Med. 2008;6(1):103-8. View abstract.

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