SWEET ORANGE

OTHER NAME(S):

Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, , Bioflavonoïde d'Agrumes, Bioflavonoïdes, Bioflavonoids, Blood Orange, Citri Sinensis, Citrus, Citrus aurantium, Citrus aurantium var. dulcis, Citrus aurantium var. sinensis, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoid Extract, Citrus Bioflavonoids, Citrus Extract, Citrus Flavones, Citrus Flavonoids, Citrus macracantha, Citrus Peel Extract, Citrus Seed Extract, Citrus sinensis, Complexe de Bioflavonoïde, Concentré de Bioflavonoïde, Extrait d'Agrume, Extrait de Bioflavonoïde, Extrait de Bioflavonoïde d'Agrumes, Extrait de Zeste d'Agrume, Flavonoïdes d'Agrumes, Flavonoids, Jaffa Orange, Jus d'Orange, Naranja Dulce, Navel Orange, Orange, Orange Bioflavonoids, Orange de Jaffa, Orange de Valence, Orange Douce, Orange Douce Sauvage, Orange Juice, Orange Peel, Orange Sanguine, Pericarpium, Red Orange, Shamouti Orange, Shamouti Sweet Orange, Valencia Orange, Wild Orange, Wild Sweet Orange, Zeste d'Orange, Zeste d'Orange Douce.<br/><br/>

Overview

Overview Information

Sweet orange is a fruit. The peel and juice are used to make medicine.

Sweet orange is most commonly used for high cholesterol, high blood pressure, and stroke prevention.

How does it work?

Sweet orange contains large amounts of vitamin C. Some researchers believe sweet orange might help asthma because of the antioxidant activity of vitamin C.

Sweet orange also contains large amounts of potassium. There is evidence that potassium may help prevent high blood pressure and stroke.

Sweet orange fruit and sweet orange juice are used to prevent kidney stones because they contain large amounts of a chemical called citrate. Citrate tends to bind with calcium before it can form kidney stones.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Preventing high blood pressure. Drinking sweet orange juice seems to help lower the risk of high blood pressure. The U.S. Food and Drug Administration (FDA) allows makers of sweet orange products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol to make label claims that their product might reduce the risk of developing high blood pressure.
  • High cholesterol. Drinking sweet orange juice seems to help improve cholesterol levels. In large amounts (750 mL, or about three 8-oz glasses, per day for four weeks), sweet orange juice seems to increase "good" high-density lipoprotein and reduce the ratio of "bad" low-density lipoprotein (LDL) to HDL cholesterol in people with high cholesterol.
  • Preventing stroke. Drinking sweet orange juice seems to help lower the risk of stroke. The U.S. Food and Drug Administration (FDA) allows makers of sweet orange products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol to make label claims that their product might reduce the risk of stroke.

Possibly Ineffective for

  • Preventing prostate cancer. Higher dietary intake of sweet orange juice is not linked with a decreased risk of prostate cancer.

Insufficient Evidence for

  • Asthma. There is some evidence that sweet orange and other fruits that are rich in vitamin C might improve lung function in people with asthma. But not all studies agree.
  • Colds. Some research shows that drinking 180 mL (about 6 ounces) of sweet orange juice daily might help prevent symptoms of the common cold.
  • Kidney stones (nephrolithiasis). Some research reports that drinking 400 mL of sweet orange juice (about 13 ounces) increases the amount of citrate in the urine. This might help to prevent kidney stones that are made of calcium.
  • Obesity. Early research shows that drinking red sweet orange juice might reduce cholesterol levels and blood pressure in people who are overweight or obese. But it does not reduce body weight or improve blood sugar levels.
  • Stress. Early research shows that smelling sweet orange essential oil during a stressful task might reduce anxiety and tension.
  • Coughs.
  • Eating disorders.
  • Cancerous breast sores.
  • Other conditions.
More evidence is needed to rate the effectiveness of sweet orange for these uses.

Side Effects

Side Effects & Safety

Sweet orange juice and fruit is LIKELY SAFE for most adults when used in food amounts. It is POSSIBLY SAFE when used as a medicine.

In children, sweet orange juice or fruit is LIKELY SAFE when used in normal food amounts. Taking large amounts of sweet orange peel is LIKELY UNSAFE. It can cause colic, convulsions, or death.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Sweet orange seems safe when taken in usual food amounts.

Interactions

Interactions?

Major Interaction

Do not take this combination

!
  • Celiprolol (Celicard) interacts with SWEET ORANGE

    Consuming large amounts of sweet orange juice might decrease how much celiprolol (Celicard) the body absorbs. This might decrease how well celiprolol (Celicard) works. Don't consume large amounts of sweet orange juice if you take celiprolol (Celicard).

  • Ivermectin interacts with SWEET ORANGE

    Drinking sweet orange juice might decrease how much ivermectin the body absorbs. Taking sweet orange along with ivermectin might decrease the effectiveness of ivermectin.

  • Pravastatin (Pravachol) interacts with SWEET ORANGE

    Drinking sweet orange juice might increase how much pravastatin (Pravachol) the body absorbs. Taking pravastatin (Pravachol) with sweet orange juice might increase drug levels in the body and possibly increase the chance of drug side effects.

Moderate Interaction

Be cautious with this combination

!
  • Antibiotics (Quinolone antibiotics) interacts with SWEET ORANGE

    Calcium-fortified sweet orange juice can reduce the amount of some antibiotics the body absorbs. Reduced absorption of antibiotics can reduce their ability to fight infection. Sweet orange juice without calcium is unlikely to affect quinolone antibiotics.<br/><br/> Some quinolone antibiotics include ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and trovafloxacin (Trovan).

  • Fexofenadine (Allegra) interacts with SWEET ORANGE

    Sweet orange might decrease how much fexofenadine (Allegra) the body absorbs. Taking sweet orange along with fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra).

  • Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with SWEET ORANGE

    Some medications are moved by pumps in cells. Sweet orange might change how these pumps work and change how much of some medications get absorbed by the body. There is not enough information to know how important this interaction might be. Until more is known sweet orange juice should be used cautious with medications moved by these pumps.<br/><br/> Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For high cholesterol: 750 mL sweet orange juice per day.
  • For preventing high blood pressure: Sweet orange juice products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol are permitted by the FDA to make labeling claims that they might reduce the risk of developing high blood pressure.
  • For preventing stroke: Sweet orange juice products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol are permitted by the FDA to make labeling claims that they might reduce the risk of stroke.

View References

REFERENCES:

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  • Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  • Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. View abstract.
  • Baird IM, Hughes RE, Wilson HK, et al. The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold. Am J Clin Nutr 1979;32:1686-90. View abstract.
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  • Carey IM, Strachan DP, Cook DG. Effects of changes in fresh fruit consumption on ventilatory function in healthy British adults. Am J Respir Crit Care Med 1998;158:728-33. View abstract.
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  • FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
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  • Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. View abstract.
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  • Silveira JQ, Dourado GK, Cesar TB. Red-fleshed sweet orange juice improves the risk factors for metabolic syndrome. Int J Food Sci Nutr. 2015;66(7):830-6. View abstract.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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© Therapeutic Research Faculty 2018.