Danshen is used for heart and blood vessel health, cancer, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Chest pain (angina). Early research shows that taking danshen with other ingredients for up to 6 months can reduce chest pain in people with heart disease about as well as taking isosorbide dinitrate.
- Liver scarring (cirrhosis). Early research shows that injecting a combination of danshen and astragalus into a vein each day improves markers of liver injury in people with liver cirrhosis. It's too soon to know if the improvement is due to astragalus, danshen, or the combination.
- Heart disease. Some research shows that taking danshen with other ingredients daily can reduce pain and cholesterol levels and improve heart function in people with heart disease.
- Vision problems in people with diabetes (diabetic retinopathy). There is some evidence that taking danshen with other ingredients for up to 24 weeks can improve vision in people with retinal damage caused by diabetes.
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Early research shows that adding danshen injections to lipid-lowering medications for 30 days decreases total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and certain blood fats called triglycerides in people with high cholesterol. It also seems to help increase high-density lipoprotein (HDL or "good") cholesterol.
- High blood pressure. Early research shows that taking danshen with other ingredients along with medication to lower blood pressure might help lower blood pressure in people with high blood pressure better than taking blood pressure-lowering medication alone.
- Kidney transplant. Early research shows that receiving an injection of danshen for 10 days improves kidney function after a kidney transplant, but does not reduce the risk of transplant rejection.
- A painful mouth disease that reduces ones ability to open the mouth (oral submucous fibrosis). Early research shows that giving danshen with a needle along with steroids helps improve symptoms of oral submucous fibrosis more than when steroids are used alone.
- Stroke. Early research shows that receiving danshen with other ingredients by mouth or injecting danshen intravenously (by IV) might improve brain function after a stroke caused by a blood clot (ischemic stroke).
- Blood clots that form in the veins (venous thromboembolism or VTE). Early research shows that taking danshen with other ingredients daily can decrease the risk of a blood clot in people receiving a certain type of chemotherapy called thalidomide.
- A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia).
- Eczema (atopic dermatitis).
- Hardening of the arteries (atherosclerosis).
- Heart attack.
- Scaly, itchy skin (psoriasis).
- Swelling (inflammation) of the liver (hepatitis).
- Swelling (inflammation) of the pancreas (pancreatitis).
- Wound healing.
- Other conditions.
When given by IV: There isn't enough reliable information to know if danshen is safe when given by IV. It might cause side effects such as itching, upset stomach, and reduced appetite.
Special Precautions and Warnings
Bleeding disorders: There is a concern that danshen might increase the risk of bleeding. If you have a bleeding disorder, don't use it.
Low blood pressure: Danshen might lower blood pressure. In theory, taking danshen might make blood pressure become too low in people with low blood pressure.
Surgery: Danshen might slow blood clotting, so there is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using danshen at least 2 weeks before a scheduled surgery.
Digoxin (Lanoxin) interacts with DANSHEN
Digoxin (Lanoxin) helps the heart beat more strongly. Danshen also seems to affect the heart. Taking danshen along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take danshen if you are taking digoxin (Lanoxin) without talking to your healthcare professional.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DANSHEN
Danshen might slow blood clotting. Taking danshen along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Warfarin (Coumadin) interacts with DANSHEN
Warfarin (Coumadin) is used to slow blood clotting. Danshen might increase how long warfarin (Coumadin) is in the body, and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Do not take this combination
Anonymous. Danshen in ischemic stroke. Chin Med J (Engl.) 1977;3(4):224-226. View abstract.
Cao, P., Feng, R., and Feng, Z. Observation of Compound Dan Shen injection and snake venom for cerebral infarction. Chinese Traditional Medicine of Guangxi 1994;17(4):3-4, 8.
Guo, Z. X., Jia, W., Gao, W. Y., Xu, Z. H., Zhao, L. B., and Xiao, P. G. Clinical investigation of composite Danshen Dripping Pill for the treatment of angina pectoris. Zhongguo Tianran Yaowu 2003;1:124-128.
Han, Y., Wang, Z. K., and Wang, Z. D. [Observation on therapeutic effect of compound salvia drop-pill in treating vasovagol syncope]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(5):452-454. View abstract.
Hu, J. and Ren, L. [Experimental study of the effect of danshen on the viability of burned skin]. Zhongguo Xiu.Fu Chong.Jian.Wai Ke.Za Zhi. 1998;12(4):205-208. View abstract.
Hung, H. H., Chen, Y. L., Lin, S. J., Yang, S. P., Shih, C. C., Shiao, M. S., and Chang, C. H. A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model. Histol.Histopathol. 2001;16(1):175-183. View abstract.
Jin, D. Z., Yin, L. L., Ji, X. Q., and Zhu, X. Z. Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. Eur J Pharmacol 11-7-2006;549(1-3):166-172. View abstract.
Kuang, P. and Xiang, J. Effect of radix salviae miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study. J Tradit Chin Med 1994;14(1):45-50. View abstract.
Kuang, P. G., Wu, W. P., Zhang, F. Y., Liu, J. X., and Pu, C. Q. The effect of radix Salviae miltiorrhizae on vasoactive intestinal peptide in cerebral ischemia: an animal experiment. J Tradit.Chin Med 1989;9(3):203-206. View abstract.
Kuang, P., Tao, Y., and Shi, J. Effect of radix Salviae miltiorrhizae on extracellular adenosine and evaluation of its protective efficacy in ischemic reperfusion rat--microdialysis, HPLC and histopathologic studies. J Tradit Chin Med 1997;17(2):140-147. View abstract.
Kuang, P., Tao, Y., and Tian, Y. Effect of radix Salviae miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury. J Tradit Chin Med 1996;16(3):224-227. View abstract.
Kuang, P., Tao, Y., and Tian, Y. Radix Salviae miltiorrhizae treatment results in decreased lipid peroxidation in reperfusion injury. J Tradit Chin Med 1996;16(2):138-142. View abstract.
Kuang, P., Wu, W., and Zhu, K. Evidence for amelioration of cellular damage in ischemic rat brain by radix salviae miltiorrhizae treatment--immunocytochemistry and histopathology studies. J Tradit Chin Med 1993;13(1):38-41. View abstract.
Li CP, Yung KH, and Chiu KW. Hypotensive action of Salvia miltiorrhiza cell culture extract. American Journal of Chinese Medicine 1990;18(3-4):157-166.
Li, W., Li, J., Ashok, M., Wu, R., Chen, D., Yang, L., Yang, H., Tracey, K. J., Wang, P., Sama, A. E., and Wang, H. A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol 3-15-2007;178(6):3856-3864. View abstract.
Liang, T. J., Zhang, C. Q., and Zhang, W. [Effect of tongxinluo capsule on plasma endothelin and calcitonin gene related peptide in patients with unstable angina pectoris]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(6):435-436. View abstract.
Liu, G. T., Zhang, T. M., Wang, B. E., and Wang, Y. W. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 1-22-1992;43(2):147-152. View abstract.
Liu, J., Kuang, P., Wu, W., Zhang, F., Liu, J., Wan, F., Huang, Y., and Ding, A. Radix Salviae miltiorrhizae protects rat hippocampal neuron in culture from anoxic damage. J Tradit Chin Med 1998;18(1):49-54. View abstract.
Liu, Q. and Chao, R. B. [Determination of danshensu in urine and its pharmacokinetics in human]. Yao Xue.Xue.Bao. 2003;38(10):771-774. View abstract.
Liu, ZL, Gao Sy, Deng J, and Li H. Analysis of effect of composite Danshen droplet pills in treatment of chronic stable angina. Chinese Traditional Patient Medicine 1997;19(7):20-21.
Mao, J. and Gan, Z. Observation of Compound Dan Shen dropping pill for cerebral infarction. Pharmacological Magazine of People's Liberation Army 2001;17(1):49-50.
Min, L. Q., Dang, L. Y., and Ma, W. Y. [Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(5):353-355. View abstract.
Min, L. Q., Yuan, J., Li, X., and et al. Influence of composite salvia miltiorrhiza on vascular endothelial cell function in patients with cerebral infarction. Chinese Journal of Clinical Rehabilitation 2004;8(16):3090-1.
Oh, S. H., Cho, K. H., Yang, B. S., and Roh, Y. K. Natural compounds from Danshen suppress the activity of hepatic stellate cells. Arch Pharm Res 2006;29(9):762-767. View abstract.
Pan, C., Chen, N., and Huo, J. 187 cases of Compound Dan Shen injection and snake venom for cerebral infarction. 1992;13(2):157-8. Chinese Traditional Medicine of Shanxi 1992;13(2):157-158.
Pei, W. J., Zhao, X. F., Zhu, Z. M., Lin, C. Z., Zhao, W. M., and Zheng, X. H. Study of the determination and pharmacokinetics of Compound Danshen Dripping Pills in human serum by column switching liquid chromatography electrospray ion trap mass spectrometry. J Chromatogr.B Analyt.Technol.Biomed.Life Sci 10-5-2004;809(2):237-242. View abstract.
She, S. F., Huang, X. Z., and Tong, G. D. [Clinical study on treatment of liver fibrosis by different dosages of Salvia injection]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(1):17-20. View abstract.
Shi, Y. H. [Comparative study of composite danshen droplet pills and sordi in treatment of patients with chronic stable angina]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1997;17(1):23-25. View abstract.
Sun AY, Zheng P, and Artmann GM. Danshen pretreatment causes pharmacologic and potent resistance to ischemic insult in rat brain. Biorheology 1999;36:73.
Tian, X. H., Xue, W. J., and Ding, X. M. [Application of Danshen injection on early stage of renal transplantation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(5):404-407. View abstract.
Wang H. Clinical analysis of 40 cases of hyperlipemia treated by acupoint-injection of Danshen. Chinese Acupuncture & Moxibustion (Chung-Kuo Chen Chiu) 1997;17(8):469-470.
Wang, G., Wang, L., Xiong, Z. Y., Mao, B., and Li, T. Q. Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis. Med Sci.Monit. 2006;12(1):SR1-SR7. View abstract.
Wasser, S., Ho, J. M., Ang, H. K., and Tan, C. E. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. J Hepatol. 1998;29(5):760-771. View abstract.
Wei, Z. M. [Effects of injection Salviae miltiorrhizae on senile chronic asthmatic bronchitis patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(7):402-404. View abstract.
Wu, H. L., Wang, X., Li, X. M., Luo, W. J., and Deng, T. T. [Trial study on DENG Tie-tao's coronary heart disease capsules in improving patients' quality of life.]. Chin J Integr.Med 2005;11(3):173-178. View abstract.
Wu, H. N. and Sun, H. [Study on clinical therapeutic effect of composite Salvia injection matched with Western medicine in treating diabetic foot]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):727-729. View abstract.
Wu, W., Kuang, P., and Li, Z. Effect of radix Salviae miltiorrhizae on the gene expression of nitric oxide synthase in ischemic rat brains. J Tradit Chin Med 1998;18(2):128-133. View abstract.
Wu, W., Kuang, P., and Li, Z. Protective effect of radix Salviae miltiorrhizae on apoptosis of neurons during focal cerebral ischemia and reperfusion injury. J Tradit Chin Med 1997;17(3):220-225. View abstract.
Wu, Z. G. and Chen, D. Y. 75 cases of coronary artery disease angina pectoris treated by compound Danshan injection and compound Danshan Drop Pill. J Changchun College Tradit Chin Med 2002;18:14.
Wu, Z. Z., Jiang, Y. Q., Yi, S. M., and Xia, M. T. Radix Salviae Miltiorrhizae in middle and late stage glaucoma. Chin Med.J (Engl.) 1983;96(6):445-447. View abstract.
Xia, Z., Gu, J., Ansley, D. M., Xia, F., and Yu, J. Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. J Thorac.Cardiovasc.Surg 2003;126(5):1404-1410. View abstract.
Xiong, L. L. [Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(9):533-537. View abstract.
Xu, Z. C. [Effect of injection Salvia miltiorrhizae on peritoneal dialysis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(2):74-6, 67. View abstract.
Yi, L. Q. and Wang, X. W. [Comparative study on treatment of severe hepatitis by Western medicine and by TCM]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(7):543-544. View abstract.
York, D. A., Thomas, S., Greenway, F. L., Liu, Z., and Rood, J. C. Effect of an herbal extract Number Ten (NT) on body weight in rats. Chin Med 2007;2:10. View abstract.
Yuan, J., Guo, W., Yang, B., Liu, P., Wang, Q., and Yuan, H. 116 cases of coronary angina pectoris treated with powder composed of radix ginseng, radix notoginseng and succinum. J Tradit.Chin Med 1997;17(1):14-17. View abstract.
Zhai, Z. L., Sun, J. H., and Zhang, J. A large dose of Dan Shen for acute ischaemic stroke. HeBei Medicine 2001;7(12):1110-1111.
Zhang, L. F., Li, L., and Li, J. C. Application of improving microcirculation in treating severe acute pancreatitis. Chin J Practl Intern Med 2002;22:163-164.
Zhang, L. J., Zhang, B. F., and Tian, F. Compound Dan Shen combined with heparin for acute ischaemic stroke. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine 2002;12(7):423.
Zhang, R. J., You, C., Cai, B. W., Wan, Y., He, M., and Li, H. [Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(10):882-884. View abstract.
Zhang, X. P., Li, Z. J., and Liu, D. R. Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis. Hepatobiliary.Pancreat.Dis Int 2006;5(4):501-504. View abstract.
Zhang, X., Kuang, P., Wu, W., Yin, X., Kanazawa, T., Onodera, K., Metoki, H., and Oike, Y. The effect of radix Salviae Miltiorrhizae Composita on peroxidation of low density lipoprotein due to copper dichloride. J Tradit Chin Med 1994;14(3):195-201. View abstract.
Zhang, X., Wu, W., Kuang, P., Takemichi, K., Kogo, O., Hirobumi, M., and Yasaburo, O. The effect of radix salviae miltiorrhizae composita and ligustrazine on lipid peroxidation in low density lipoprotein due to copper dichloride. J Tradit Chin Med 1994;14(4):292-297. View abstract.
Zhou, S., Shao, W., and Duan, C. [Observation of preventing and treating effect of Salvia miltiorrhiza composita on patients with ischemic coronary heart disease undergoing non-heart surgery]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(2):75-76. View abstract.
Zhou, W. and Ruigrok, T. J. Protective effect of danshen during myocardial ischemia and reperfusion: an isolated rat heart study. Am J Chin Med 1990;18(1-2):19-24. View abstract.
Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. View abstract.
Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5. View abstract.
Chow L, Johnson M, Wells A, Dasgupta A. Effect of the traditional Chinese medicines Chan Su, Lu-Shen-Wan, Dan Shen, and Asian ginseng on serum digoxin measurement by Tina-quant (Roche) and Synchron LX system (Beckman) digoxin immunoassays. J Clin Lab Anal 2003;17:22-7. View abstract.
Chu Y, Zhang L, Wang XY, Guo JH, Guo ZX, Ma XH. The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Ethnopharmacol. 2011 Oct 11;137(3):1457-61. View abstract.
Dasgupta, A., Actor, J. K., Olsen, M., Wells, A., and Datta, P. In vivo digoxin-like immunoreactivity in mice and interference of Chinese medicine Danshen in serum digoxin measurement: elimination of interference by using a chemiluminescent assay. Clin Chim.Acta 2002;317(1-2):231-234. View abstract.
Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: https://www.ars-grin.gov/duke/.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. View abstract.
Huang J, Tang X, Ye F, He J, Kong X. Clinical therapeutic effects of aspirin in combination with fufang danshen diwan, a traditional Chinese medicine formula, on coronary heart diseases: a systematic review and meta-analysis. Cell Physiol Biochem. 2016;39(5):1955-63. View abstract.
Huang W, Bao Q, Jin, Lian F. Compound danshen dripping pill for treating nonproliferative diabetic retinopathy: a meta-analysis of 13 randomized controlled trials. Evid Based Complement Alternat Med. 2017;2017:4848076. View abstract.
Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. View abstract.
Jia Y, Leung SW. How efficacious is danshen (salvia miltiorrhiza) dripping pill in treating angina pectoris? Evidence assessment for meta-analysis of randomized controlled trials. J Altern Complement Med. 2017 Sep;23(9):676-84. View abstract.
Lai CL, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Han KH, Yuen MF. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2014 Jun;63(6):996-1004. View abstract.
Lian F, Wu L, Tian J, et al. The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: a randomized, double-blind, placebo-controlled multicenter clinical trial. J Ethnopharmacol. 2015 Apr 22;164:71-7. View abstract.
Lv C, Liu C, Yao Z, et al. The clinical pharmacokinetics and pharmacodynamics of warfarin when combined with compound danshen: a case study for combined treatment of coronary heart diseases with atrial fibrillation. Front Pharmacol. 2017 Nov 21;8:826. View abstract.
Ma S, Ju W, Dai G, Zhao W, Cheng X, Fang Z, Tan H, Wang X. Synergistic effects of clopidogrel and fufang danshen dripping pills by modulation of the metabolism target and pharmacokinetics. Evid Based Complement Alternat Med. 2014;2014:789142. View abstract.
Qi Y, Yu C, Tang L, Li S, Sun X. Patient characteristics associated with treatment response in patients receiving salvianolate injection for stable angina. J Evid Based Med 2018;11(2):83-8. doi: 10.1111/jebm.12282. View abstract.
Qiu F, Jiang J, Ma Y, Wang G, Gao C, Zhang X, Zhang L, Liu S, He M, Zhu L, Ye Y, Li Q, Miao P. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evid Based Complement Alternat Med. 2013;2013:730734. View abstract.
Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. View abstract.
Qiu F, Zeng J, Liu S, He M, Zhu L, Ye Y, Miao P, Shen S, Jiang J. Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers. Evid Based Complement Alternat Med. 2014;2014:473213. View abstract.
Roberts AT, Martin CK, Liu Z, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10:184-8. View abstract.
Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.
Tan, K. Q., Zhang, C., Liu, M. X., and Qiu, L. [Comparative study on therapeutic effects of acupuncture, Chinese herbs and Western medicine on nervous tinnitus]. Zhongguo Zhen Jiu 2007;27(4):249-251. View abstract.
Van Poppel PC, Breedveld P, Abbink EJ, et al. Salvia miltiorrhiza root water-extract (danshen) has no beneficial effect on cardiovascular risk factors. A randomized double-blind cross-over trial. PLoS One. 2015 Jul 20;10(7):e0128695. View abstract.
Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. View abstract.
Wang K, Zhang D, Wu J, Liu S, Zhang X, Zhang B. A comparative study of danhong injection and salvia miltiorrhiza injection in the treatment of cerebral infarction: a systematic review and meta-analysis. Medicine (Baltimore). 2017 Jun;96(22):e70079. View abstract.
Wang N, Luo HW, Niwa M, Ji J. A new platelet aggregation inhibitor from Salvia miltiorrhiza. Planta Med 1989;55:390-1.
Wang T, Fu X, Wang Z. Danshen formulae for cancer: A systematic review and meta-analysis of high-quality randomized controlled trials. Evid Based Complement Alternat Med. 2019;2019:2310639. View abstract.
Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine. 2010 Sep;17(11):868-75. View abstract.
Wang X, Yeung JH. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine. 2012 Feb 15;19(3-4):348-54. View abstract.
Wen JH, Xiong YQ. The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):205-11. View abstract.
Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. View abstract.
Wu JR, Liu S, Zhang XM, Zhang B. Danshen injection as adjuvant treatment for unstable angina pectoris: a systematic review and meta-analysis. Chin J Integr Med. 2017 Apr;23(4):306-11. View abstract.
Xie H, Guo J, Tan B, Wu H. Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2019;98(27):e16339. View abstract.
Xue, Y. P., Zhang, S. B., and Gao, T. [Observation on therapeutic effect of chronic prostatitis treated mainly by warming needle moxibustion]. Zhongguo Zhen Jiu 2006;26(5):335-336. View abstract.
Yang TY, Wei JC, Lee MY, Chen CM, Ueng KC. A randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of Fufang Danshen (Salvia miltiorrhiza) as add-on antihypertensive therapy in Taiwanese patients with uncontrolled hypertension. Phytother Res. 2012 Feb;26(2):291-8. View abstract.
Yao Y, Feng Y, Lin W. Systematic review and meta-analysis of randomized controlled trials comparing compound danshen dripping pills and isosorbide dinitrate in treating angina pectoris. Int J Cardiol. 2015 Mar 1;182:46-7. View abstract.
Yin QS, Chen L, Mi RH, Ai H, Yin JJ, Liu XJ, Wei XD. Efficacy and safety of danshen compound tablets in preventing thalidomide-associated thromboembolism in patients with multiple myeloma: a multicenter retrospective study. Med Sci Monit. 2016 Oct 20;22:3835-42. View abstract.
Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. View abstract.
Zhang H, Han X, Li Y, Li H, Guo X. Effects of danshen tablets on pharmacokinetics of amlodipine in rats. Pharm Biol. 2019;57(1):306-309. View abstract.
Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 2014 Jul 3;154(3):672-86. View abstract.
Zhou L, Wang S, Zhang Z, Lau BS, Fung KP, Leung PC, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 2012 Sep 28;143(2):648-55. View abstract.
Zhou X, Chan K, Yeung JH. Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes. Drug Metabol Drug Interact. 2012 Mar 2;27(1):9-18. View abstract.
Zhu C, Cao H, Zhou X, Dong C, Luo J, Zhang C, Liu J, Ling Y. Meta-analysis of the clinical value of danshen injection and huangqi injection in liver cirrhosis. Evid Based Complement Alternat Med. 2013;2013:842824. View abstract.
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.