DANSHEN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Danshen is an herb. The root is commonly used in Traditional Chinese Medicine. It is often combined with other herbs.

Danshen is used for heart and blood vessel health, cancer, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

Danshen appears to thin the blood by preventing platelet and blood clotting. It also causes blood vessels to widen, and this can improve circulation.

Uses & Effectiveness ?

We currently have no information for DANSHEN overview.

Side Effects

Special Precautions and Warnings

When taken by mouth: Danshen is POSSIBLY SAFE when taken by mouth by most people. It can cause some side effects, including itching, upset stomach, and reduced appetite.

When given by IV: There isn't enough reliable information to know if danshen is safe when given by IV. It might cause side effects such as itching, upset stomach, and reduced appetite. Pregnancy and breast-feeding: There isn't enough reliable information to know if danshen is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: There is a concern that danshen might increase the risk of bleeding. If you have a bleeding disorder, don't use it.

Low blood pressure: Danshen might lower blood pressure. In theory, taking danshen might make blood pressure become too low in people with low blood pressure.

Surgery: Danshen might slow blood clotting, so there is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using danshen at least 2 weeks before a scheduled surgery.

Interactions ?

Major Interaction

Do not take this combination

Digoxin (Lanoxin) interacts with DANSHEN
Digoxin (Lanoxin) helps the heart beat more strongly. Danshen also seems to affect the heart. Taking danshen along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take danshen if you are taking digoxin (Lanoxin) without talking to your healthcare professional.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DANSHEN
Danshen might slow blood clotting. Taking danshen along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Moderate Interaction

Be cautious with this combination

Warfarin (Coumadin) interacts with DANSHEN
Warfarin is used to slow blood clotting. Danshen might increase how long warfarin stays in the body and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of warfarin might need to be changed.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen use might increase how quickly the body breaks down some medications. Taking danshen along with some medications that are broken down by the liver might decrease the effectiveness of some of these medications. Before taking danshen talk to your healthcare provider if you are taking any medications that are changed by the body.

Some medications changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and others.
Midazolam (Versed) interacts with DANSHEN
Midazolam (Versed) is changed and broken down by the body. Danshen might increase how quickly midazolam (Versed) is broken down by the body. This might decrease the effects of midazolam (Versed).
Medications for high blood pressure (Antihypertensive drugs) interacts with DANSHEN
Danshen might lower blood pressure. Using danshen with drugs that lower blood pressure might cause blood pressure to drop too much.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Aspirin interacts with DANSHEN
Taking danshen along with aspirin might increase how much aspirin is in the blood. This might increase the effects and side effects of aspirin.
Clopidogrel (Plavix) interacts with DANSHEN
Clopidogrel (Plavix) is changed and broken down by the liver. Danshen might decrease how quickly clopidogrel (Plavix) is changed and broken down by the liver. This might increase the effects and side effects of clopidogrel (Plavix).
Fexofenadine (Allegra) interacts with DANSHEN
Fexofenadine (Allegra) is moved by pumps in cells. Danshen might make these pumps less active and increase the amount of fexofenadine (Allegra) that gets absorbed by the body. This might increase the amount of fexofenadine (Allegra) in the body, which could lead to more side effects.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might decrease how quickly the liver breaks down some medications. Taking danshen along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking danshen, talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might decrease how quickly the liver breaks down some medications. Taking danshen along with some medications that are changed by the liver might increase the effects and side effects of some of these medications. Before taking danshen, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), and celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others. Use danshen cautiously or avoid in patients taking these drugs.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might decrease how quickly the liver breaks down some medications. Taking danshen along with some medications that are changed by the liver might increase the effects and side effects of some of these medications. Before taking danshen, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).
Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with DANSHEN
Some medications are moved by pumps in cells. Danshen might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects.
Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Rosuvastatin (Crestor) interacts with DANSHEN
Danshen might increase levels of rosuvastatin (Crestor) in the blood. This might increase the effects and side effects of rosuvastatin (Crestor).
Amlodipine (Norvasc) interacts with DANSHEN
Taking danshen along with amlodipine might decrease how much amlodipine is in the blood. This might decrease the effects of amlodipine.

Dosing

The appropriate dose of danshen depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for danshen. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

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Xie H, Guo J, Tan B, Wu H. Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2019;98(27):e16339. View abstract.

Xue, Y. P., Zhang, S. B., and Gao, T. [Observation on therapeutic effect of chronic prostatitis treated mainly by warming needle moxibustion]. Zhongguo Zhen Jiu 2006;26(5):335-336. View abstract.

Yang TY, Wei JC, Lee MY, Chen CM, Ueng KC. A randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of Fufang Danshen (Salvia miltiorrhiza) as add-on antihypertensive therapy in Taiwanese patients with uncontrolled hypertension. Phytother Res. 2012 Feb;26(2):291-8. View abstract.

Yao Y, Feng Y, Lin W. Systematic review and meta-analysis of randomized controlled trials comparing compound danshen dripping pills and isosorbide dinitrate in treating angina pectoris. Int J Cardiol. 2015 Mar 1;182:46-7. View abstract.

Yin QS, Chen L, Mi RH, Ai H, Yin JJ, Liu XJ, Wei XD. Efficacy and safety of danshen compound tablets in preventing thalidomide-associated thromboembolism in patients with multiple myeloma: a multicenter retrospective study. Med Sci Monit. 2016 Oct 20;22:3835-42. View abstract.

Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. View abstract.

Zhang H, Han X, Li Y, Li H, Guo X. Effects of danshen tablets on pharmacokinetics of amlodipine in rats. Pharm Biol. 2019;57(1):306-309. View abstract.

Zhang Y, Yang M, Ho NJ, et al. Is it safe to take Radix Salvia Miltiorrhiza - Radix Pueraria Lobate product with warfarin and aspirin? A pilot study in healthy human subjects. J Ethnopharmacol. 2020 Nov 15;262:113151. View abstract.

Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 2014 Jul 3;154(3):672-86. View abstract.

Zhou L, Wang S, Zhang Z, Lau BS, Fung KP, Leung PC, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 2012 Sep 28;143(2):648-55. View abstract.

Zhou X, Chan K, Yeung JH. Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes. Drug Metabol Drug Interact. 2012 Mar 2;27(1):9-18. View abstract.

Zhu C, Cao H, Zhou X, Dong C, Luo J, Zhang C, Liu J, Ling Y. Meta-analysis of the clinical value of danshen injection and huangqi injection in liver cirrhosis. Evid Based Complement Alternat Med. 2013;2013:842824. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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DANSHEN - Uses, Side Effects, and More

Overview

How does it work ?

Uses & Effectiveness ?

Side Effects

Special Precautions and Warnings

Interactions ?

Major Interaction

Digoxin (Lanoxin) interacts with DANSHEN

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DANSHEN

Moderate Interaction

Warfarin (Coumadin) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DANSHEN

Midazolam (Versed) interacts with DANSHEN

Medications for high blood pressure (Antihypertensive drugs) interacts with DANSHEN

Aspirin interacts with DANSHEN

Clopidogrel (Plavix) interacts with DANSHEN

Fexofenadine (Allegra) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with DANSHEN

Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with DANSHEN

Rosuvastatin (Crestor) interacts with DANSHEN

Amlodipine (Norvasc) interacts with DANSHEN

Dosing

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