BC-PS, Bovine Cortex Phosphatidylserine, Bovine Phosphatidylserine, Fosfatidilserina, LECI-PS, Lecithin Phosphatidylserine, Phosphatidylsérine, Phosphatidylsérine Bovine, Phosphatidylsérine de Soya, Phosphatidyl Serine, PS, PtdSer, Soy-PS, Soy Phosphatidylserine.<br/><br/>
Overview InformationPhosphatidylserine is a chemical. The body can make phosphatidylserine, but gets most of what it needs from foods. Phosphatidylserine supplements were once made from cow brains, but now are commonly manufactured from cabbage or soy. The switch was triggered by a concern that products made from animal sources might cause infections such as mad cow disease.
Phosphatidylserine is most commonly used for improving mental function, especially in the elderly.
How does it work?Phosphatidylserine is an important chemical with widespread functions in the body. It is part of the cell structure and is key in the maintenance of cellular function, especially in the brain.
Uses & Effectiveness
Possibly Effective for
- Age-related mental decline. Phosphatidylserine seems to improve attention, language skills, and memory in aging people with declining thinking skills. Most research has used phosphatidylserine from cow brains. But most phosphatidylserine supplements are now made from soy or cabbage. It is not as well known whether these newer products made from plants have the same benefit. But there is early evidence that plant-derived phosphatidylserine also improves memory in people with age-related memory loss. Also, some research shows that taking a product containing plant-derived phosphatidylserine enriched with the fatty acid DHA helps improve memory and attention in older women complaining of memory loss. The product seems to work best in people with less severe symptoms.
- Alzheimer's disease. Taking phosphatidylserine can improve some of the symptoms of Alzheimer's disease after 6-12 weeks of treatment. It seems to work best in people with less severe symptoms. But phosphatidylserine might become less effective over time. After 16 weeks of treatment, progression of Alzheimer's disease seems to overcome any benefit provided by phosphatidylserine.
Most research has used phosphatidylserine from cow brains. But most phosphatidylserine supplements are now made from soy or cabbage. Researchers do not yet know how phosphatidylserine made from these plant sources compares with phosphatidylserine made from cow brains in terms of effectiveness for Alzheimer's disease.
Insufficient Evidence for
- Improving athletic performance. Taking phosphatidylserine for 6 weeks before playing golf might improve how well a golfer tees off. But it doesn't seem to reduce stress or heart rate during golf competition. Other research shows that taking phosphatidylserine with caffeine and vitamins might improve mood and reduce feelings of tiredness after exercising. But these improvements are likely to be small, and it's not clear if the benefit is from phosphatidylserine or other ingredients.
- Attention deficit-hyperactivity disorder (ADHD). Research shows that taking plant-derived phosphatidylserine helps improve attention, impulse control, and hyperactivity in children and teens with ADHD.
- Stress brought on by exercise. Some research suggests that athletes taking phosphatidylserine during strenuous training might feel better overall and have less muscle soreness. However, other research shows conflicting results.
- Depression. There is some early evidence that phosphatidylserine might improve depression in older people.
- Sore muscles caused by exercise. Some research shows that taking phosphatidylserine during strenuous training might help reduce muscle soreness after exercise.
- Improving thinking ability.
- Other conditions.
Side Effects & SafetyPhosphatidylserine is POSSIBLY SAFE most adults and children when taken by mouth appropriately. It has been used in safely in clinical research for up to 6 months in adults and up to 4 months in children.
Phosphatidylserine can cause side effects including insomnia and stomach upset, particularly at doses over 300 mg.
There is some concern that products made from animal sources could transmit diseases, such as mad cow disease. To date, there are not any known cases of humans getting animal diseases from phosphatidylserine supplements. But look for supplements made from plants to be on the safe side.
Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking phosphatidylserine if you are pregnant or breast feeding. Be on the safe side and avoid use.
Be cautious with this combination
Drying medications (Anticholinergic drugs) interacts with PHOSPHATIDYLSERINE
Some drying medications are called anticholinergic drugs. Phosphatidylserine might increase chemicals that can decrease the effects of these drying medications.<br/><br/> Some drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines) and for depression (antidepressants).
Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors) interacts with PHOSPHATIDYLSERINE
Phosphatidylserine might increase a chemical in the body called acetylcholine. Medications for Alzheimer's disease called acetylcholinesterase inhibitors also increase the chemical acetylcholine. Taking phosphatidylserine along with medications for Alzheimer's disease might increase effects and side effects of medications for Alzheimer's disease.<br/><br/> Some acetylcholinesterase medications include donepezil (Aricept), tacrine (Cognex), rivastigmine (Exelon), and galantamine (Reminyl, Razadyne).
Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs) interacts with PHOSPHATIDYLSERINE
Phosphatidylserine might increase a chemical in the body called acetylcholine. This chemical is similar to some medications used for glaucoma, Alzheimer's disease, and other conditions. Taking phosphatidylserine with these medications might increase the chance of side effects.<br/><br/> Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), and others.
The following doses have been studied in scientific research:
- For age-related mental decline: 100 mg of phosphatidylserine from cow brains or plant sources has been taken three times daily for up to 6 months. Also 1-3 capsules of a specific product (Vayacog, Enzymotec Ltd.) containing phosphatidylserine (PS) enriched with the fatty acid DHA have been taken daily for 15 weeks.
- For Alzheimer's disease: 300-400 mg of phosphatidylserine has been taken daily in divided doses.
- Cornish, S. M. and Chilibeck, P. D. Alpha-linolenic acid supplementation and resistance training in older adults. Appl.Physiol Nutr.Metab 2009;34(1):49-59. View abstract.
- Gracious, B. L., Chirieac, M. C., Costescu, S., Finucane, T. L., Youngstrom, E. A., and Hibbeln, J. R. Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Bipolar.Disord. 2010;12(2):142-154. View abstract.
- Oomen, C. M., Ocke, M. C., Feskens, E. J., Kok, F. J., and Kromhout, D. alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. Am J Clin Nutr. 2001;74(4):457-463. View abstract.
- Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., and Zampelas, A. Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 2003;167(2):237-242. View abstract.
- Wilkinson, P., Leach, C., Ah-Sing, E. E., Hussain, N., Miller, G. J., Millward, D. J., and Griffin, B. A. Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 2005;181(1):115-124. View abstract.
- Allman MA, Pena MM, Pang D. Supplementation with flaxseed oil versus sunflower seed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr 1995;49:169-78. View abstract.
- Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178. View abstract.
- Alonso L, Marcos ML, Blanco JG, et al. Anaphylaxis caused by linseed (flaxseed) intake. J Allergy Clin Immunol 1996;98:469-70. View abstract.
- Ascherio A, Rimm EB, Giovannucci EL, et al. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 1996;313:84-90. View abstract.
- Barceló-Coblijn G, Murphy EJ, Othman R, et al. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am J Clin Nutr 2008;88:801-9. View abstract.
- Barden, A. E., Croft, K. D., Durand, T., Guy, A., Mueller, M. J., and Mori, T. A. Flaxseed oil supplementation increases plasma F1-phytoprostanes in healthy men. J Nutr 2009;139(10):1890-1895. View abstract.
- Barre DE, Mizier-Barre KA, Griscti O, Hafez K. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. J Oleo Sci 2008;57:269-73. View abstract.
- Bierenbaum ML, Reichstein R, Watkins TR, and et al. Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report. J Am Coll Nutr. 1993;12:501-504.
- Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. View abstract.
- Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. View abstract.
- Bougnoux, P., Koscielny, S., Chajes, V., Descamps, P., Couet, C., and Calais, G. alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. Br.J Cancer 1994;70(2):330-334. View abstract.
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22. View abstract.
- Chavarro JE, Stampfer MJ, Li H, et al. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2007;16:1364-70. View abstract.
- Christensen JH, Christensen MS, Toft E, et al. Alpha-linolenic acid and heart rate variability. Nutr Metab Cardiovasc Dis 2000;10:57-61. View abstract.
- Clandinin, M. T., Foxwell, A., Goh, Y. K., Layne, K., and Jumpsen, J. A. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. Biochim.Biophys.Acta 6-23-1997;1346(3):247-252. View abstract.
- Crawford M, Galli C, Visioli F, et al. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. Ann Nutr Metab 2000;44:263-5. View abstract.
- Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53. View abstract.
- Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. View abstract.
- de Deckere EAM, Korver O, Verschuren PM, Katan MB. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 1998;52:749-53. View abstract.
- de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994;343:1454-9. View abstract.
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8. View abstract.
- Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322. View abstract.
- Nerozzi, D., Aceti, F., Melia, E., Magnani, A., Marino, R., Genovesi, G., Amalfitano, M., Cozza, G., Murgiano, S., De, Giorgis G., and . [Phosphatidylserine and memory disorders in the aged]. Clin.Ter. 3-15-1987;120(5):399-404. View abstract.
- Palmieri, G., Palmieri, R., Inzoli, MR Lombardi G., Sottini, C., Tavolato, B., and Giometto, B. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J 1987;24:73-83.
- Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044. View abstract.
- Ransmayr, G., Plorer, S., Gerstenbrand, F., and Bauer, G. Double-blind placebocontrolled trial of phosphatidylserine in elderly patients with arteriosclerotic encephalopathy. Clin Trials J 1987;24:62-72.
- Rosadini, G., Sannita, W. G., Nobili, F., and Cenacchi, T. Phosphatidylserine: quantitative EEG effects in healthy volunteers. Neuropsychobiology 1990;24(1):42-48. View abstract.
- Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M., and Jager, R. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc.Sports Nutr 2008;5:11. View abstract.
- Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y., and Korczyn, A. D. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement.Geriatr Cogn Disord 2010;29(5):467-474. View abstract.
- Villardita, J. C., Grioli, S., Salmeri, G., Nicoletti, F., and Pennisi, G. Multicenter clinical trial of brain phosphatidylserine in elderly patiens with intellectual deterioration. Clin Trials J 1987;24:84-93.
- Amaducci L. Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol Bull 1988;24:130-4.
- Benton D, Donohoe RT, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci 2001;4:169-78. View abstract.
- Blokland A, Honig W, Brouns F, Jolles J. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition 1999;15:778-83. View abstract.
- Cenacchi T, Bertoldin T, Farina C, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano) 1993;5:123-33. View abstract.
- Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6. View abstract.
- Crook TH, Tinklenberg J, Yesavage J, et al. Effects of phosphatidylserine in age-associated memory impairment. Neurology 1991;41:644-9. View abstract.
- Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff M. Double-blind, randomized, controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scand 1986;73:136-40. View abstract.
- Engel RR, Satzger W, Gunther W, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol 1992;2:149-55. View abstract.
- Fahey TD, Pearl MS. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Biol Sport 1998;15:135-44.
- Funfgeld EW, Baggen M, Nedwidek P, et al. Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT). Prog Clin Biol Res 1989;317:1235-46. View abstract.
- Heiss WD, Kessler J, Mielke R, et al. Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation. Dementia 1994;5:88-98. View abstract.
- Hirayama S, Terasawa K, Rabeler R, et al. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet. 2014;27 Suppl 2:284-91. View abstract.
- Kidd PM. Attention Deficit/Hyperactivity disorder (ADHD) in children: rationale for its integrative management. Altern Med Rev 2000;5:402-28. View abstract.
- Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
- Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. View abstract.
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Maggioni M, Picotti GB, Bondiolotti GP, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand 1990;81:265-70. View abstract.
- Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000;101:841-3.. View abstract.
- Monastra G, Cross AH, Bruni A, et al. Phosphatidylserine, a putative inhibitor of tumor necrosis factor, prevents autoimmune demyelination. Neurology 1993;43:153-63.. View abstract.
- Monteleone P, Beinat L, Tanzillo C, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology 1990;52:243-8.. View abstract.
- Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol 1992;42:385-8.. View abstract.
- Palmieri G, Palmieri R, Inzoli MR, et al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J 1987;24:73-83.
- Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
- Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7. View abstract.
- Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geriatr Cogn Disord. 2014;38(1-2):39-45. View abstract.
- Villardita C, Grioli S, Salmeri G, et al. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J 1987;24:84-93.
- Wells AJ, Hoffman JR, Gonzalez AM, et al. Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans. Nutr Res 2013;33:464-72. View abstract.
- Yamazaki M, Inoue A, Koh CS, et al. Phosphatidylserine suppresses Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol 1997;75:113-22.. View abstract.
- Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. View abstract.
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