Q10 (CoQ10) is a substance similar to a vitamin. It is found in every cell of
the body. Your body makes CoQ10, and your cells use it to produce energy your
body needs for cell growth and maintenance. It also functions as an
antioxidant, which protects the body from damage
caused by harmful molecules. CoQ10 is naturally present in small amounts in a
wide variety of foods, but levels are particularly high in organ meats such as
heart, liver, and kidney, as well as beef, soy oil, sardines, mackerel, and
Adult-onset Still's disease is an inflammatory disease that may affect many joints, internal organs, and other parts of the body. Adult Still's develops most often in people before age 45, but can first occur in later years as well. The cause of Still's is unknown and there are no known risk factors. It is thought that a virus or other type of infectious agent may trigger Still's disease, but there is no proof of this.
Although some features are similar, adult-onset Still's disease is...
If you have heart failure, talk
to your doctor before you take any supplement. There's no strong evidence that
vitamins or other supplements can help treat heart
They are used along with medical heart failure treatments, not instead of treatment.
But you may still hear
about CoQ10 supplements and heart failure. CoQ10 has not been shown definitely to relieve heart
failure symptoms. Only some of the studies of coenzyme Q10 showed that it helps heart
In 1961, scientists saw that people with
cancer had little CoQ10 in their blood. They found low CoQ10 blood levels in
people with myeloma,
lymphoma, and cancers of the breast, lung, prostate,
pancreas, colon, kidney, and head and neck. Some research has suggested that
CoQ10 helps the
immune system and may be useful as a secondary
treatment for cancer.
CoQ10 may keep the antitumor drug doxorubicin
from hurting the heart.
Three studies examined the use of CoQ10
along with conventional treatment for cancer. The three studies contained a
total of 41 women with breast cancer. In each study, the women improved.
But the National Cancer Institute (NCI) rates the strength of
the evidence for CoQ10 and cancer as weak.2
Research does not
support a helpful effect of CoQ10 in periodontal (gum) disease, muscular
dystrophy, or exercise recovery.
Is CoQ10 safe?
Taking 100 mg a day or more of CoQ10 has caused mild
insomnia in some people. And research has detected
elevated levels of liver enzymes in people taking doses of 300 mg per day for
long periods of time. Liver toxicity has not been reported.
high cholesterol (statins) and medicines that lower
blood sugar cause a decrease of CoQ10 levels and reduce the effects of CoQ10
supplements. CoQ10 can reduce the body's response to the blood thinner (anticoagulant) medicine warfarin (Coumadin) and can
decrease insulin requirements in people with
The U.S. Food and Drug
Administration (FDA) does not regulate dietary supplements in the same way it
regulates medicines. A dietary supplement can be sold with limited or no
research on how well it works or on its safety.
Always tell your
doctor if you are using a dietary supplement or if you are thinking about
combining a dietary supplement with your conventional medical treatment. It may
not be safe to forgo your conventional medical treatment and rely only on a
dietary supplement. This is especially important for women who are pregnant or
When using dietary supplements, keep in mind the
Like conventional medicines, dietary supplements
may cause side effects, trigger allergic reactions, or interact with
prescription and nonprescription medicines or other supplements you might be
taking. A side effect or interaction with another medicine or supplement may
make other health conditions worse. Always tell your doctor or pharmacist about
all dietary supplements you are taking.
The way dietary
supplements are manufactured may not be standardized. Because of this, how well
they work or any side effects they cause may differ among brands or even within
different lots of the same brand. The form of supplement that you buy in health
food or grocery stores may not be the same as the form used in research.
Other than for vitamins and minerals, the long-term effects of most
dietary supplements are not known.
Coenzyme Q10 (2006). Medical Letter on Drugs and Therapeutics, 48(1229): 19-20.
National Cancer Institute (2010). Coenzyme Q10. Available online: http://cancer.gov/cancertopics/pdq/cam/coenzymeQ10/healthprofessional/allpages.
Primary Medical Reviewer
Adam Husney, MD, MD - Family Medicine
Specialist Medical Reviewer
Marc S. Micozzi, MD, PhD - Complementary and Alternative Medicine
June 29, 2011
WebMD Medical Reference from Healthwise
June 29, 2011
This information is not intended to replace the advice of a doctor.
Healthwise disclaims any liability for the decisions you make based on this