Fatigue is often confused with tiredness. Tiredness happens to everyone -- it's a feeling you expect after certain activities or at the end of the day. Usually, you know why you are tired and a good night's sleep solves the problem.
Fatigue is a daily lack of energy; it is excessive whole-body tiredness not relieved by sleep. It can last for a short time (a month or less) or stay around for longer (six months or longer). Fatigue can prevent you from functioning normally and gets in the way of things you enjoy or need to do.
For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.
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Cancer-related fatigue is one of the most common side effects of cancer and its treatment. It is not predictable by tumor type, treatment, or stage of illness. Usually, it comes on suddenly, does not result from activity or exertion, and is not relieved by rest or sleep. It is often described as "paralyzing" and may continue even after treatment is complete.
What Causes Cancer-Related Fatigue?
The exact reason for cancer-related fatigue is unknown. It may be related to the disease itself or its treatments.
The following cancer treatments are commonly associated with fatigue:
Chemotherapy. Any chemotherapy drug may cause fatigue. Fatigue usually develops after several weeks of chemotherapy. In some, fatigue lasts a few days, while others say the problem persists throughout the course of treatment and even after the treatment is complete.
Radiation therapy. Radiation can cause fatigue that increases over time. This can occur regardless of the treatment site. Fatigue usually lasts from three to four weeks after treatment stops, but can continue for up to two to three months.
Combination therapy. More than one cancer treatment at the same time or one after the other increases the chances of developing fatigue.
Bone marrow transplant. This aggressive form of treatment can cause fatigue that lasts up to one year.
Biologic therapy. Biologics can also cause fatigue.
What Else Contributes to Cancer-Related Fatigue?
Cancer cells compete for nutrients, often at the expense of the normal cells' growth. In addition to fatigue, weight loss and decreased appetite are common.
Decreased nutrition from the side effects of treatments (such as nausea, vomiting, mouth sores, taste changes, heartburn, or diarrhea) can cause fatigue.