Fatigue (PDQ®): Supportive care - Health Professional Information [NCI] - Pathogenesis of Fatigue
Finally, another theory is that serotonin is negatively impacted through chronic exposure to proinflammatory cytokines. One hypothesis is that the relationship between central nervous system concentrations of serotonin and fatigue have a U-shaped relationship, suggesting that very high and very low levels of serotonin may be associated with cancer-related fatigue. However, studies that have evaluated serotonergic agents have not demonstrated a benefit for fatigue. The role and relationship of many important neurotransmitters such as dopamine, norepinephrine, and serotonin with HPA axis functioning and cytokine expression have yet to be fully understood.
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