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Sometimes diet and exercise alone can’t protect you from the risks of high triglycerides. To lower them, your body needs an extra nudge in the form of medicine.

Your doctor will likely prescribe meds if you have: 

  • Very high triglycerides -- over 500 mg/dL
  • Both high triglycerides and high "bad" LDL cholesterol levels 

Your doctor will consider many factors when choosing the right medicine for you. For instance, are you taking other meds? What is your overall health?  

Your doctor will consider these main types of triglycerides meds:

  • Fibrates
  • Niaspan
  • Prescription-strength omega-3 fatty acids


In addition to lowering triglycerides, most fibrates also lower cholesterol as well as ApoB, a protein found in LDL "bad" cholesterol.

Medicine names:

  • Atromid-S (clofibrate)
  • Lipofen and Tricor (fenofibrate)
  • Fibricor and Trilipix (fenofibric acid)
  • Gemcor and Lopid (gemfibrozil)

You should not take fibrates if you have liver, kidney, or gallbladder disease.

Medicines that can interact: Before taking fibrates, be sure to tell your doctor about other supplements and meds you take, especially:

  • Blood thinners (anticoagulants) such as Coumadin (warfarin)
  • Oral diabetes medicines
  • Cholesterol-lowering meds including Lipitor (atorvastatin), Prandin (repaglinide), or Zocor (simvastatin)
  • Insulin



This class of medicine reduces triglycerides and also improves cholesterol levels. Niacin lowers the amount of LDL cholesterol as well as ApoB. Plus, it increases the amount of HDL "good" cholesterol.

Medicine name: Niaspan (niacin)

You should not take niacin if you have:

  • An allergy to aspirin, niacin, or tartrazine (a yellow dye in some medicines and processed foods)
  • Any bleeding problems
  • Diabetes
  • Gallbladder disease
  • Heart disease
  • Liver problems or jaundice
  • A stomach ulcer
  • Plan to have any type of surgery, including dental procedures

Medicines that can interact: Before you take niacin, be sure to tell your doctor if you:

  • Take supplements or meds such as blood thinners (anticoagulants), which includes Coumadin (warfarin).
  • Take insulin or oral diabetes meds (Niacin can increase blood sugar levels, so your doctor may need to change your dose.)
  • Drink large amounts of alcohol

Prescription-Strength Omega-3 Fatty Acids

This class of medicines lower levels of triglycerides and may increase HDL "good" cholesterol.

Medicine names:

  • Epanova (omega-3-carboxylic acids)
  • Lovaza (omega-3-acid ethyl esters)
  • Vascepa (icosapent ethyl)

You should not take prescription omega-3s if you:

  • Are allergic to fish or shellfish
  • Drink more than two glasses of alcohol each day
  • Have diabetes, liver, pancreatic, or thyroid disease

Medicines that could interact: Tell your doctor if you take meds such as:

  • Aspirin or aspirin-containing medicines
  • Blood thinners (anticoagulants) such as Coumadin (warfarin) or Plavix (clopidogrel)
  • Birth control that contains estrogen
  • Estrogen replacement therapy
  • Certain high blood pressure or heart medicines, such as beta-blockers or diuretics

When You Also Have High Cholesterol

High triglycerides and high cholesterol often go hand in hand. If you have both conditions, your doctor might also want you to take a cholesterol-lowering medicine. These meds can slightly lower triglycerides, too. There are three main groups:

  • Cholesterol absorption inhibitors: Zetia (ezetimibe)
  • Statins: Such as Crestor (rosuvastatin), Lipitor (atorvastatin), and Zocor (simvastatin)
  • Statin combination drugs: Such as Advicor (niacin extended-release and lovastatin) and Simcor (niacin extended-release and simvastatin)