Skip to content

Depression Health Center

Select An Article

Treatment-Resistant Depression

Font Size

How well is your depression treatment working? Does it help a bit, but you still don't feel as if the darkness has lifted? Perhaps you feel the treatment isn't working at all. If so, you could have treatment-resistant depression, also called refractory depression.

Unfortunately, depression treatments don't always work. As many as two-thirds of people with depression aren't helped by the first antidepressant they try. Up to a third don't respond to several attempts at treatment.

Recommended Related to Depression

Can Antidepressants Work for Me?

How effective are antidepressants? That's a question that many people with depression have asked -- and research suggests that the answers aren't simple. It's a question that's relevant to millions. About one in 10 Americans takes an antidepressant, now the most commonly prescribed type of drug in the U.S., according to research published in 2009 in the Archives of General Psychiatry. Much of the surge has happened in the past two decades. From 1996 to 2005, the rate of antidepressant use rose...

Read the Can Antidepressants Work for Me? article > >

Treatment-resistant depression (TRD) can leave you feeling hopeless and discouraged. Months or even years can go by without any relief. And after the effort it took to get help, it can be demoralizing when you're just not getting better.

But if your depression treatment isn't working, don't give up. Many people can get their treatment-resistant depression under control. You and your doctor just need to find the right approach. This might include different drugs, therapy, and other treatments. If you're still struggling with depression despite treatment, here's what you need to know.

Understanding Treatment-Resistant Depression

What is treatment-resistant depression? Surprisingly, that can be hard to answer. Experts still disagree on what exactly the term means.

Some researchers define TRD as a case of depression that doesn't respond to two different antidepressants from different classes. Other experts say that a person needs to try at least four different treatments before depression can be truly considered treatment-resistant.

Of course for you, the exact definition doesn't matter. You just need to ask yourself some basic questions.

  • Has your treatment failed to make you feel better?
  • Has your treatment helped a bit, but you still don’t feel like your old self?
  • Have the side effects of your medication been hard to handle?

If the answer is yes to any of these, you need to see your doctor. Whether or not you actually have treatment-resistant depression, you need expert help.

Treatment-Resistant Depression: Getting Help

Although a primary care doctor can treat depression (research suggests that 60%-65% of antidepressants are prescribed by primary care physicians), it may be best to see a specialist, like a psychiatrist, if you think you may have treatment-resistant depression. It's a good idea to also work with a therapist, like a psychologist or social worker, because the best treatment is often a combination of medicine and therapy.

Next Article:

Today on WebMD

Differences between feeling depressed and feeling blue.
jk rowling
Famous people who've struggled with persistent sadness.
depressed man sitting on hallway floor
Learn the truth about this serious illness.
Sad woman looking out of the window
Tips to stay the treatment course.
unhappy teen boy
Health Check
jk rowling
Pills with smiley faces
Teen girl huddled outside house
Depressed man sitting in hospital hallway
antidepressants slideshow
pill bottle
Winding path