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Print ArticleRecognizing the Symptoms of Depression
Common Causes of Depression
Health experts' understanding of depression has come a long way in the last few decades. In many cases, depression doesn't have only one cause. It often results from a mix of biology, psychology, and stressful or traumatic events.
Reasons for depression include:
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Biology. Researchers still have a lot to learn about
exactly why people become depressed. But some experts say depression often
results from an imbalance of certain chemicals in the brain. These chemicals
are called neurotransmitters. Antidepressants work by affecting the levels of
these chemicals — bringing them back into balance.
There's also a genetic connection. If depression runs in your family, you have a higher chance of becoming depressed.
Having other general health conditions or diseases can increase your risk of depression. For instance, if you have a heart attack, you have a 65% risk of becoming depressed afterwards. Conditions such as cancer, heart disease, thyroid problems, and many others increase your risk of becoming depressed.
Your gender makes a difference, too. Women are about twice as likely as men to become depressed. No one's sure why. But the hormonal changes that women go through at different times of their lives may be a factor. - Psychology. Studies show that people who have a pessimistic personality are more likely to become depressed. This doesn't mean that getting a "better attitude" will resolve your depression.
- Stressful events. Many people become depressed during difficult times. Losing a family member or close friend, being diagnosed with a serious illness, going through a divorce, or any other traumatic event may trigger depression.
- Medications and substances. Many prescription drugs can cause the symptoms of depression. Alcohol or substance abuse is common in depressed people. It often makes their condition worse.
Some people have a clear sense of why they become depressed. Others don't. The most important thing to remember is that depression is not your fault. It's not a flaw in your character. It's a disease that can affect anyone.
WebMD Medical Reference
Important Safety Information
Cymbalta® (duloxetine HCl) is approved for the treatment of depression and generalized anxiety disorder, and for the management of diabetic peripheral neuropathic pain and fibromyalgia.
What should I talk about with my healthcare provider?
Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, unusual changes in behavior, thoughts of suicide, anxiety, agitation, panic attacks, difficulty sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness, or extreme hyperactivity. Call your healthcare provider right away if you have thoughts of suicide or if any of these symptoms are severe or occur suddenly. Be especially observant within the first few months of antidepressant treatment or whenever there is a change in dose.
You should also know that:
- Suicide is a known risk of depression and some other psychiatric disorders.
- Antidepressants may increase suicidal thoughts or behaviors in some children, adolescents, and young adults especially within the first few months of treatment or when changing the dose. No increased risk has been shown for adults over age 24, and risk decreased for those over age 65.
- All patients starting therapy should be monitored appropriately and observed closely for new or worsening depression symptoms, suicidal thoughts or behavior, or unusual changes in behavior.
- Cymbalta® is not approved for use in patients under age 18.
Who should NOT take Cymbalta?
You should not take Cymbalta if:
- You have recently taken a type of antidepressant called a monoamine oxidase inhibitor (MAOI)
- You have uncontrolled narrow-angle glaucoma (an eye disease)
- You are taking Mellaril® (thioridazine)
What other important information should I discuss with my healthcare provider?
Before starting Cymbalta, tell your healthcare provider:
- about all of your medical conditions, including kidney problems, glaucoma, or diabetes
- about your alcohol use
- if you are taking nonprescription or prescription medicines, including those for migraine, to address a possible life threatening condition
- if you are taking NSAID pain relievers, aspirin, or blood thinners. Use with Cymbalta may increase bleeding risk
- if you are pregnant, plan to become pregnant during therapy, or are breastfeeding an infant
While taking Cymbalta, tell your healthcare provider:
- if you have itching, right upper belly pain, dark urine, yellow skin/eyes, or unexplained flu-like symptoms, which may be signs of liver problems. Severe liver problems, sometimes fatal, have been reported
- if you have high fever, confusion, and stiff muscles to address a possible life-threatening condition
- before stopping Cymbalta or changing your dose
- if you experience dizziness or fainting upon standing, especially when first starting Cymbalta or when increasing the dose. Your healthcare provider may periodically check your blood pressure while you are taking Cymbalta
If you have any questions, talk to your healthcare provider before taking Cymbalta.
What are the possible side effects of Cymbalta?
The most common side effect of Cymbalta was nausea. For most people who had it, the nausea was mild to moderate. Other common side effects included dry mouth, sleepiness, constipation, decreased appetite, and, increased sweating. This is not a complete list of side effects.
Depression Glossary
- Antidepressant: Drugs to be used to treat depression...
- Dysphoria: An emotional state marked by anxiety, depression, and restlessness ...
- Dysthymia: Chronic depression that is less severe than major depression ...
- Major Depression: Depression that lasts for at least two weeks and interferes with daily life ...
- Psychotherapy: Treatment by talking about emotional problems ...
- View All Terms
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