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Depression usually strikes more than once in a lifetime. For many people, it can become a chronic or lifelong illness, with several relapses or recurrences. On average, most people with depression will have four to five episodes during their lifetimes.

Doctors define relapse as another episode of depression that happens fewer than six months after you've been treated for acute depression. A recurrence is a new episode that comes after six months or longer since the previous episode has resolved. Regardless of the timeline, it can be demoralizing to feel depression symptoms, such as sadness, fatigue, and irritability, creeping back into your life.

If you believe that you're facing depression a second time (or more), talk to your doctor, psychiatrist, or therapist right away about getting treatment again.


A depression relapse or recurrence can be treated in various ways, sometimes through a combination of therapies. For example, your doctor may recommend both antidepressant treatment and psychotherapy.


Doctors use several drugs to treat depression, including:

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs)
  • Norepinephrine and dopamine reuptake inhibitors (NDRIs), which include bupropion

Older classes of antidepressants can be effective, too, but aren't used as frequently today because they pose the potential risk of serious side effects. These older drugs include:

  • Tricyclics
  • Monoamine oxidase inhibitors (MAOIs)

In addition, your doctor may pair your antidepressant with atypical antipsychotic medicines, mood stabilizers, anti- anxiety drugs, stimulants, or other medications.

Ask your doctor if you need to take antidepressants or other medications for your new episode of depression. If you're already on "maintenance therapy" -- for example, using an antidepressant to prevent recurrence -- your doctor may alter the dose of an existing medicine or otherwise change your current drug regimen to find more effective treatment.


Counseling, or "talk therapy," can help you to understand your problems, including new issues that have arisen since you were last treated for depression. You'll explore better ways to cope or to solve problems. Through psychotherapy, you can also learn how to manage your own thoughts and actions so that you feel less depressed.