Skip to content

    Diabetes Health Center

    Font Size

    Sulfonylureas for Type 2 Diabetes


    Generic Name Brand Name
    chlorpropamide Diabinese
    glimepiride Amaryl
    glipizide Glucotrol, Glucotrol XL
    glyburide DiaBeta, Glynase PresTab, Micronase

    Sulfonylureas are also available in combination pills. Glyburide is combined with the biguanide medicine metformin (Glucovance). Glipizide is combined with metformin (Metaglip). Glimepiride is combined with the thiazolidinedione medicines rosiglitazone (Avandaryl) and pioglitazone (Duetact).

    How It Works

    Sulfonylurea medicines increase the amount of insulin produced by the pancreas, and insulin lowers blood sugar.

    Why It Is Used

    Sulfonylurea medicines are prescribed for people with type 2 diabetes when eating healthy foods, weight loss, and exercise do not keep the blood sugar level within a target range. They are helpful for people who cannot make enough insulin or who have become resistant to the insulin the body makes.

    These medicines can help control blood sugar levels in children and young adults who have type 2 diabetes and are overweight.

    How Well It Works

    Type 2 diabetes is a disease that can get worse over time, so medicines may need to change.

    Diabetes medicines work best for people who are being active and eating healthy foods. Studies have suggested that sulfonylureas lower hemoglobin A1c by 1% to 2%.1

    Side Effects

    All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

    Here are some important things to think about:

    • Usually the benefits of the medicine are more important than any minor side effects.
    • Side effects may go away after you take the medicine for a while.
    • If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

    Call911or other emergency services right away if you have:

    Call your doctor if you have:

    Common side effects of this medicine include:

    See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

    What To Think About

    Sulfonylurea medicines increase insulin levels even if you have not eaten food. Watch for symptoms of low blood sugar, especially if you drink alcohol.

    People with kidney or liver problems might not be able to take sulfonylurea medicines.

    Skin can be more easily sunburned when taking tolbutamide or tolazamide. Chlorpropamide can cause a skin rash.

    Taking medicine

    Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.

    There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.

    Advice for women

    If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.


    Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.

    Sulfonylurea medicines are an effective treatment for many people who have type 2 diabetes. If one of these medicines keeps your blood sugar within a target range, your risks of long-term complications of diabetes can be reduced. Other important factors that contribute to complications include high blood pressure, being overweight, high cholesterol levels, and smoking.

    Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.


    1. Inzucchi SE, et al. (2012). Management of hyperglycemia in type 2 diabetes: A patient-centered approach. Diabetes Care, 35(6): 1364-1379.

    ByHealthwise Staff
    Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
    Specialist Medical ReviewerDavid C.W. Lau, MD, PhD, FRCPC - Endocrinology

    Current as ofNovember 14, 2014

    WebMD Medical Reference from Healthwise

    Last Updated: November 14, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

    Today on WebMD

    Diabetic tools
    Symptoms, diagnosis, treatment, and more.
    woman flexing muscles
    10 strength training exercises.
    Blood sugar test
    12 practical tips.
    Tom Hanks
    Stars living with type 1 or type 2.
    kenneth fujioka, md
    Can Vinegar Treat Diabetes
    Middle aged person
    jennie brand miller

    Prediabetes How to Prevent Type 2 Diabetes
    type 2 diabetes
    food fitness planner