What is an Insulinoma?

An insulinoma is a tumor of the pancreas. That’s the organ that makes the hormone insulin, which controls your blood sugar.

Normally, the pancreas makes more insulin when your blood sugar is high and less when those levels drop. But when you have an insulinoma, the tumor will keep making insulin even when your blood sugar gets too low.

These tumors are usually small (less than an inch), and almost all of them are not cancer. In most cases, surgery can cure the problem.


Because these tumors make too much insulin, they can cause symptoms of low blood sugar, also known as hypoglycemia. You could have:

Hypoglycemia can be dangerous. If your blood sugar drops very low, you could faint or go into a coma.

Hypoglycemia is common in people with diabetes. It often happens because they took too much of their medicine, missed a meal, or got more exercise than usual, all of which can lower blood sugar. An insulinoma can also cause hypoglycemia when you haven’t eaten in a while, but it can happen at any time.

What Causes an Insulinoma?

It’s not clear why some people get these tumors. Women are slightly more likely to have them than men, and most people get them between ages 40 and 60. You’re also more likely to have an insulinoma if you have certain genetic diseases, including:

Getting a Diagnosis

It can be tough for doctors to diagnose an insulinoma. Its symptoms are the same as other common health problems. It may take time before your doctor can find it.

To find out if you have an insulinoma, your doctor will need to confirm:

  • You have symptoms of low blood sugar, especially after not eating or heavy exercise
  • Your blood sugar is actually low when you have those symptoms
  • Your symptoms go away after your blood sugar goes up


To do that, your doctor will need to watch what happens to your blood sugar after you fast for a day to two. You may need to stay in the hospital during this time, and you won’t be able to eat or drink anything except water. Your doctor will test your blood to see if you have both low blood sugar and a high insulin level.

You may also get an imaging test such as a CT scan so your doctor can see where the tumor is.


The main treatment for an insulinoma is surgery to remove the tumor. Most of the time, that will cure you.

The type of surgery you get depends on the type, size, and location of the tumor. Surgeons can usually remove just the insulinoma from the surface of the pancreas and leave the organ intact.

Sometimes the surgeon may need to remove part of the pancreas connected to the tumor. But this type of surgery is less common.

You might be able to have laparoscopic surgery to remove an insulinoma. In this operation, doctors make several smaller cuts in your body instead of one large one. They use special instruments to do the surgery. That means you’ll have less pain as you heal, stay fewer days in the hospital, and can return to normal life more quickly.

Most people won’t need any more treatment after surgery.

If your doctor thinks surgery won’t work for you, you can try other treatments to manage low blood sugar. You might take medicine and eat smaller meals more often throughout the day.

Cancerous insulinomas are rare, and they need different treatment. If your doctor can’t remove the whole tumor, you may need to take other medicine to prevent low blood sugar. You may also need chemotherapy. Depending  on the type of tumor you have, another treatment option is getting a radioactive medicine called lutetium Lu 177 dotatate (Lutathera). This medicine is given through an IV. This drug works by attaching itself to part of the tumor cell, and the radiation from the drug damages the cell.

WebMD Medical Reference Reviewed by Laura J. Martin, MD on April 29, 2018



World Journal of Gastroenterology: “Diagnosis and Management of Insulinoma.”

Harvard Health Publications: “Hypoglycemia.”                                                                                         

Hopkinsmedicine.org: “Insulinoma.”

Diapedia.org: “Insulinoma.”

Mayo Clinic: “Hypoglycemia.”

University of Southern California Center for Pancreatic and Biliary Diseases: “Insulinoma.”

University of Southern California Center for Pancreatic and Biliary Diseases: “Laparoscopic Surgery for Endocrine Tumors.”

Cancer.Net: “Multiple Endocrine Neoplasia Type 1,” “Von Hippel Lindau Syndrome.”

National Organization for Rare Disorders: “Neurofibromatosis 1.”

Tuberous Sclerosis Alliance: “About TSC.”

FDA. "FDA approves new treatment for certain digestive tract cancers."

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