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    Pioglitazone-Glimepiride

    precautions

    What should I know regarding pregnancy, nursing and administering Pioglitazone-Glimepiride to children or the elderly?

    If you are:

    Pregnant:

    FDB Only When Necessary: INSUFF HUMAN DATA; POORLY CONTROLLED DIABETES MAY INCREASE MATERNAL/FETAL RISK

    Only When Necessary: RISK OF HYPOGLYCEMIA IN NEONATE IF USED NEAR DELIVERY

    Nursing:

    Precaution: INSUFFICIENT DATA AVAILABLE; ALTERNATIVE AGENTS MAY BE PREFERRED

    Absolute Contraindication: NOT RECOMMEND;EXCRETED IN RATS; POSSIBILITY OF HYPOGLYCEMIA IN NURSING INFANT

    An adult over 60:

    management or monitoring precaution: Renal-Decreased renal function increases risk of hypoglycemia. Initiate at low dose, titrate slowly.

    management or monitoring precaution: Cardiovascular-Box warning states the drug may cause or exacerbate CHF. Contraindicated in patients with NYHA Class III or IV heart failure. Monitor for weight gain, peripheral edema and new onset dyspnea. Hepatic-Monitor for elevations of serum transaminases. Musculoskeletal-Consider increased fracture risk.

    Giving pioglitazone-glimepiride to a child under 12:

    Severe Precaution: Not recommended in pediatrics. Risk of hypoglycemia and weight gain.

    Severe Precaution: Possible risks include fracture, fluid retention and heart failure, bladder tumor. Not recommended.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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