If you are:
Precaution: INSUFFICIENT HUMAN DATA; EXCRETED IN ANIMALS, MFR ADVISES CAUTION
An adult over 60:
management or monitoring precaution: General-Monitor closely for development or reactivation of severe infection. Infection rates may be higher in the elderly.
Giving Simponi Syringe to a child under 12:
Severe Precaution: Increased risk of malignancy, lymphoma, fatality. No established safety and efficacy age < 18 years.