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Drugs & Medications

trametinib

Uses

Trametinib may be used alone or in combination with another medication (dabrafenib) to treat a type of skin cancer (melanoma) that has a certain type of abnormal "BRAF" gene and has spread or cannot be removed by surgery. Trametinib works by slowing the growth of skin cancer cells. It belongs to a class of drugs known as kinase inhibitors.

How to use trametinib

Read the Patient Information Leaflet if available from your pharmacist before you start taking trametinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily at least 1 hour before or 2 hours after a meal.

If you are also taking dabrafenib, take trametinib by mouth as directed by your doctor, usually once a day with either the morning or the evening dose of dabrafenib. Ask your doctor or pharmacist for more details.

The dosage is based on your medical condition and response to treatment.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Side Effects

Dizziness, diarrhea, stomach pain, dry/itchy skin, acne, and dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

Pain or sores in the mouth and throat may occur. Brush your teeth carefully/gently, avoid using mouthwash that contains alcohol, and rinse your mouth frequently with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Trametinib may cause or worsen high blood pressure. Check your blood pressure regularly and tell your doctor right away of high results.

Tell your doctor right away if you have any serious side effects, including: signs of heart failure (such as swelling ankles/feet/hands, trouble breathing, sudden unexplained weight gain), signs of lung disease (such as cough, shortness of breath, rapid breathing, fast heartbeat, mental/mood changes), signs of skin infection (such as red/peeling/warm skin), signs of muscle damage (such as muscle pain/tenderness/weakness, fever, unusual tiredness, change in the amount of urine), easy bleeding/bruising.

Trametinib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, tell your doctor immediately if you develop any rash.

Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as blurred vision, loss of vision, blind spots/shadows in the center of your vision, sensitivity to light).

Trametinib in combination with dabrafenib may infrequently cause other serious side effects. (See also the Side Effects section of the dabrafenib monograph.) Get medical help right away if you have any very serious side effects, including: signs of bleeding in the brain (such as severe headache, weakness on one side of the body, vision problems, slurred speech, seizures, or confusion), signs of stomach/intestinal bleeding (such as black/bloody stools, vomit that contains blood or looks like coffee grounds, or dizziness), sudden pain/swelling/redness, usually in the leg, chest pain, trouble breathing, new lumps/growth.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking trametinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, heart disease (heart failure).

This drug may make you dizzy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy while taking this medication and for 4 months after treatment. Therefore, females must use reliable forms of birth control during treatment and for 4 months after treatment. If you become pregnant or think you may be pregnant, tell your doctor immediately.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as BRAF testing, heart imaging, blood pressure readings) should be performed before you start treatment, periodically to monitor your progress, or to check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is within 12 hours of your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store in the refrigerator in the original container away from light and moisture. Do not freeze. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised January 2014. Copyright(c) 2014 First Databank, Inc.

Images

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This medicine is a yellow, oval, film-coated tablet imprinted with "GS" and "TFC".
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This medicine is a pink, round, film-coated tablet imprinted with "GS" and "HMJ".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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