Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Amiodarone may prevent agalsidase from working.
What might happen:
Your agalsidase may not work as well in treating your Fabry disease.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Replagal (agalsidase alfa) Canadian prescribing information. Paladin Labs, Inc. January, 2004.
2.Fabrazyme (agalsidase beta) UK summary of product characteristics. Genzyme Europe July 22, 2003.