People with Crohn's disease can experience periods of severe symptoms followed by periods of remission that can last for weeks or years. The symptoms of Crohn's disease depend on where the disease occurs in the bowel and its severity. In general, symptoms can include:
Other symptoms can develop, depending on complications related to the disease. For example, a person with a fistula (abnormal passageway between various organs or tissues) in the rectal area may have pain and leaking discharge around the rectum.
Although there are many theories about what causes Crohn's disease, none of them have been proven. There is a benefit, though, in understanding the possible causes of Crohn's disease and how they interact with one another. Doing so can help one better understand the symptoms, diagnosis, and treatment of Crohn's disease.
Scientists believe that Crohn's disease is caused by a combination of these factors:
Immune system problems
How might each of these factors...
Severe inflammation and obstruction of various parts of the gastrointestinal tract due to swelling and scar formation can cause other problems like bowel perforation, abdominal distension (swelling), severe pain, and fever. This can be life-threatening.
Crohn’s is a disorder of uncertain etiology. It has often been thought of as an autoimmune disease but research suggests that the chronic inflammation may not be due to the immune system attacking the body itself, but rather a result of the immune system attacking harmless virus, bacteria or food in the gut causing inflammation that leads to bowel injury. Crohn's disease can cause other parts of the body can become inflamed (due to chronic inflammatory activity) including the joints, eyes, mouth, and skin. In addition, gallstones and kidney stones may also develop as a result of Crohn's disease.
Moreover, children with the disease may experience decreased growth or delayed sexual development.
What Causes Crohn's Disease?
The cause of Crohn's disease is unknown. However, it is likely due to an abnormal response of the immune system. Food or bacteria in the intestines, or even the lining of the bowel may cause the uncontrolled inflammation associated with Crohn's disease.
Who Gets Crohn's Disease?
Crohn's disease is often inherited. About 20% of people with Crohn's disease may have a close relative with either Crohn's or ulcerative colitis. In addition, Jewish people of European descent (Ashkenazi) are at greater risk for the disease.
While Crohn's disease can affect people of all ages, it is primarily an illness of the young. Most people are diagnosed before age 30, but the disease can occur in people in their 60's, 70's, or even later in life.