New Treatment for Menopause Symptoms
2-Drug Combo May Reduce Menopause Symptoms While Building Bone
Menopause Symptom Relief
Though both studies offer promise, perhaps the aspect of TSEC that will
interest most women is the potential improvement of menopausal symptoms --
problems like hot flashes or vaginal dryness.
"Two of the phase III trials looked at hot flushes, and the combination
appears very effective in significantly reducing not only the number, but the
severity," says Pickar. This is significant since SERM medications,
particularly at high doses, often increase hot flashes.
Moreover, he adds that vaginal symptoms such as dryness and thinning also
responded favorably to this TSEC. SERMs alone have no impact on these
Although there have been no specific studies on either the protective
effects or risks of TSEC on heart health, thus far Pickar says no adverse
cardiovascular events have been reported. He adds that the incidence of blood
clots and stroke previously associated with hormone therapy "was not
different than placebo in our two-year trial of TSEC."
A head-to-head study comparing TSEC with HRT is under way with results
expected later this year. Goldstein cautions that there is still much we don't
know about this new approach to treating menopause.
"It could be the answer we have been searching for, but women need to
realize that there are still many questions that need to be answered before we
can say for certain this is a revolutionary treatment option."
Wyeth plans to submit data for drug approval to the FDA in the latter part
of 2007. If approved, the first TSEC drug could be available by prescription as
early as mid-2008.
- Will you consider this new
treatment? Share your thoughts on WebMD's Menopause Support Group message