Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Menopause Health Center

Font Size

New Treatment for Menopause Symptoms

2-Drug Combo May Reduce Menopause Symptoms While Building Bone

What We Know Right Now

In the first of the two new trials being presented, researchers looked at the impact of TSEC on the endometrium (the lining of the uterus) in nearly 4,000 women aged 40 to 75 over the course of two years.

The study showed that new cases of endometrial hyperplasia (a thickening of the lining frequently associated with estrogen therapy and sometimes a precursor to cancer) were similar to placebo. Moreover, there was also no increase in bleeding and spotting or breast pain, all common side effects of hormonal therapy.

In the second study, doctors tested the same TSEC on bone mineral density (BMD). They found that it yielded a greater increase in bone mineral density of the spine and hip when compared with placebo or Evista, another SERM.

Menopause Symptom Relief

Though both studies offer promise, perhaps the aspect of TSEC that will interest most women is the potential improvement of menopausal symptoms -- problems like hot flashes or vaginal dryness.

"Two of the phase III trials looked at hot flushes, and the combination appears very effective in significantly reducing not only the number, but the severity," says Pickar. This is significant since SERM medications, particularly at high doses, often increase hot flashes.

Moreover, he adds that vaginal symptoms such as dryness and thinning also responded favorably to this TSEC. SERMs alone have no impact on these symptoms.

Although there have been no specific studies on either the protective effects or risks of TSEC on heart health, thus far Pickar says no adverse cardiovascular events have been reported. He adds that the incidence of blood clots and stroke previously associated with hormone therapy "was not different than placebo in our two-year trial of TSEC."

A head-to-head study comparing TSEC with HRT is under way with results expected later this year. Goldstein cautions that there is still much we don't know about this new approach to treating menopause.

"It could be the answer we have been searching for, but women need to realize that there are still many questions that need to be answered before we can say for certain this is a revolutionary treatment option."

Today on WebMD

woman walking outdoors
How to handle headaches, night sweats, and more.
mature woman holding fan in face
Symptoms and treatments.
woman hiding face behind hands
11 ways to keep skin bright and healthy.
Is it menopause or something else?
senior couple
mature woman shopping for produce
Alcohol Disrupting Your Sleep
mature couple on boat
mature woman tugging on her loose skin
senior woman wearing green hat
estrogen gene

WebMD Special Sections