Estrogen Tells Brain Where Fat Goes
Future 'Designer Estrogen' Might Prevent Menopause Weight Gain
Aug. 20, 2007 -- A woman's brain uses estrogen to balance food intake with
energy output -- and to tell fat where to go.
That's why women not only gain weight after menopause, but also why the
weight they gain goes to the wrong places, suggest Deborah J. Clegg, PhD, and
colleagues at the University of Cincinnati.
Clegg and colleagues used recently developed "gene silencing"
techniques to inactivate a set of switches in the brains of female rats. The
switches are estrogen receptors, which normally respond to estrogen. Clegg and
colleagues removed these receptors from a specific part of the brain that
controls food intake, energy expenditure, and fat distribution.
What happened? The rats' bodies slowed down. They had less energy. And they
began to gain weight, even though they weren't given any extra food.
Moreover, the rats put on belly fat -- fatty tissue around the abdominal
organs -- the most dangerous kind of fat. It's linked to heart disease and
"Women are protected from these negative consequences as long as they
carry their weight in their hips and saddlebags," Clegg says in a news
release. "But when they go through menopause and the body fat shifts to the
abdomen, they have to start battling all of these medical
Clegg's hope is that her studies will lead to the development of
"designer estrogen therapies" that would target these brain regions and
reduce a menopausal woman's tendency to gain weight.
Clegg reported the findings at the 234th national meeting of the American