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    Kleine-Levin Syndrome

    Important
    It is possible that the main title of the report Kleine-Levin Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    Disorder Subdivisions

    • None

    General Discussion

    Kleine-Levin syndrome is a rare disorder characterized by the need for excessive amounts of sleep (hypersomnolence), (i.e., up to 20 hours a day); excessive food intake (compulsive hyperphagia); and behavioral changes such as an abnormally uninhibited sexual drive. The disorder primarily affects adolescent males. When awake, affected individuals may exhibit irritability, lack of energy (lethargy), and/or lack of emotions (apathy). They may also appear confused (disoriented) and experience hallucinations. Symptoms of Kleine-Levin syndrome are cyclical. An affected individual may go for weeks or months without experiencing symptoms. When present, symptoms may persist for days to weeks. In some cases, the symptoms associated with Kleine-Levin syndrome eventually disappear with advancing age. However, episodes may recur later during life.

    The exact cause of Kleine-Levin syndrome is not known. However, researchers believe that in some cases, hereditary factors may cause some individuals to have a genetic predisposition to developing the disorder. It is thought that symptoms of Kleine-Levin syndrome may be related to malfunction of the portion of the brain that helps to regulate functions such as sleep, appetite, and body temperature (hypothalamus). Some researchers speculate that Kleine-Levin syndrome may be an autoimmune disorder.

    Resources

    National Sleep Foundation
    1010 N. Glebe Road
    Suite 310
    Arlington, VA 22201
    Tel: (703)243-1697
    Email: nsf@sleepfoundation.org
    Internet: http://www.sleepfoundation.org

    American Sleep Association
    1610 14th Street NW
    Suite 300
    Rochester, MN 55901
    Tel: (507)287-6006
    Fax: (507)287-6008
    Email: asda@millcomm.com
    Internet: http://www.sleepassociation.org/

    National Mental Health Consumers' Self-Help Clearinghouse
    1211 Chestnut Street
    Suite 1207
    Philadelphia, PA 19107-6312
    USA
    Tel: (215)751-1810
    Fax: (215)636-6312
    Tel: (800)553-4539
    Email: info@mhselfhelp.org
    Internet: http://www.mhselfhelp.org

    Mental Health America
    2000 N. Beauregard Street, 6th Floor
    Alexandria, VA 22314-2971
    USA
    Tel: (703)684-7722
    Fax: (703)684-5968
    Tel: (800)969-6642
    TDD: (800)433-5959
    Email: infoctr@mentalhealthamerica.net
    Internet: http://www.mentalhealthamerica.net/

    NIH/National Institute of Mental Health
    Health Science Writing, Press and Dissemination Branch
    6001 Executive Boulevard
    Room 8184, MSC 9663
    Bethesda, MD 20892-9663
    Tel: (301)443-4513
    Fax: (301)443-4279
    Tel: (866)615-6464
    TDD: (301)443-8431
    Email: nimhinfo@nih.gov
    Internet: http://www.nimh.nih.gov/index.shtml

    NIH/National Institute of Neurological Disorders and Stroke
    P.O. Box 5801
    Bethesda, MD 20824
    Tel: (301)496-5751
    Fax: (301)402-2186
    Tel: (800)352-9424
    TDD: (301)468-5981
    Internet: http://www.ninds.nih.gov/

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Kleine-Levin Syndrome Foundation
    PO Box 5382
    San Jose, CA 95150-5382
    Tel: (408)265-1099
    Fax: (408)269-2131
    Email: facts@klsfoundation.org
    Internet: http://www.klsfoundation.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 4/6/2007
    Copyright 1996, 1997, 2001, 2003, 2005, 2007 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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