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MESOGLYCAN

Other Names:

Aortic GAGs, Aortic Glycosaminoglycans, Glycosaminoglycans, Glycosaminoglycanes, Glycosaminoglycannes, Heparinoid Fraction, Heparinoids, Héparinoïdes, Mesoglicano, Mésoglycane, Mucopolysaccharide, Sulfomucopolysaccharide.

MESOGLYCAN Overview
MESOGLYCAN Uses
MESOGLYCAN Side Effects
MESOGLYCAN Interactions
MESOGLYCAN Dosing
MESOGLYCAN Overview Information

Mesoglycan is a substance obtained from cow lung or cow blood vessel (aorta) or pig intestine. It is used as medicine for various blood vessel disorders. Depending on the use, mesoglycan is taken by mouth, or applied to the skin, or given by injection into the muscle (intramuscularly) or the bloodstream (intravenously, by IV).

Mesoglycan is used for treating “hardening of the arteries” (atherosclerosis); hemorrhoids; swelling (inflammation) of the blood vessels (vasculitis); poor blood circulation that can lead to varicose veins and other blood vessel problems; leg ulcers; high blood fat levels, especially high triglycerides; and stroke.

It is also used for reducing leg pain during walking that is often experienced by people with peripheral artery disease (PAD).

Mesoglycan is sometimes used to improve thinking skills in people with poor blood circulation in the brain.

Another use is prevention of blood clots in the legs (deep venous thrombosis, DVT).

Mesoglycan is sometimes applied directly to the skin for treating leg ulcers.

Healthcare providers give mesoglycan as a shot to treat poor blood circulation, leg ulcers, heart disease, and stroke. They give it intravenously to treat lower limb ischemia, a condition in which enough oxygen doesn’t get to the tissues in the legs because of blood vessel problems.

How does it work?

Mesoglycan appears to have effects that improve blood flow and reduce the risk of clotting.

MESOGLYCAN Uses & Effectiveness What is this?

Possibly Effective for:

  • Treating poor circulation that can lead to varicose veins and other conditions. There is some evidence mesoglycan, given by mouth or as an injection, may improve the symptoms associated with various vein conditions including varicose veins and swollen veins (phlebitis) when used over a 1-3 month period. Applying mesoglycan directly to the skin also seems to be helpful for treating leg ulcers in people with poor circulation.
  • Treating leg ulcers. Administering a combination of mesoglycan, given by mouth and as an injection, seems to boost the effectiveness of usual treatment for leg ulcers.
  • Reducing pain when walking in people with a disease called peripheral arterial disease. Alternating intravenous and oral mesoglycan seems to improve walking distance in patients with leg pain due to peripheral arterial disease.
  • Improving thinking and quality of life in people with limited blood flow to the brain. Taking mesoglycan by mouth seems to improve oxygenation of the brain and quality of life when used over a 6-month period. There is some evidence that mesoglycan might work about as well as standard treatment with medications that thin the blood.
  • Reducing blood levels of certain fats called triglycerides.

Possibly Ineffective for:


Insufficient Evidence for:

  • “Hardening of the arteries” (atherosclerosis). There is some early evidence that mesoglycan might slow the progression of atherosclerosis by keeping blood vessel walls from thickening.
  • Swelling (inflammation) of blood vessels (vasculitis). There is some developing evidence that mesoglycan given as a shot might be useful for treating some people with this condition.
  • Hemorrhoids.
  • Other conditions.
More evidence is needed to rate the effectiveness of mesoglycan for these uses.


MESOGLYCAN Side Effects & Safety

Mesoglycan seems safe for most adults when taken by mouth. It can cause nausea, vomiting, heartburn, headache, diarrhea, and skin reactions.

Because mesoglycan comes from animal products, there is a risk that diseases could be accidentally transmitted from sick animals.

There isn’t enough information to know whether mesoglycan is safe when used applied to the skin or given by IV.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of mesoglycan during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Clotting problems: Mesoglycan might cause bleeding in people with clotting problems. Use with caution.

An allergy to the blood thinner heparin: Mesoglycan might cause allergic reactions in people who are allergic to heparin or related drugs.

Surgery: Mesoglycan might slow blood clotting. There is some concern that it might cause extra bleeding if used near the time of surgery. Stop using mesoglycan at least 2 weeks before a scheduled surgery.

MESOGLYCAN Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications for dissolving blood clots (Thrombolytic drugs) interacts with MESOGLYCAN

    Mesoglycan decreases blood clotting. Taking mesoglycan with medications used for dissolving blood clots might increase the chance of bleeding and bruising.
    Some medications used for dissolving blood clots include alteplase (Activase), anistreplase (Eminase), reteplase (Retevase), streptokinase (Streptase), and urokinase (Abbokinase).

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with MESOGLYCAN

    Mesoglycan might slow blood clotting. Taking mesoglycan along with medications that also slow clotting might increase the chances of bruising and bleeding.
    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.


MESOGLYCAN Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For preventing disorders of blood flow to the brain: mesoglycan 100-144 mg per day.
  • For high triglycerides: mesoglycan 96 mg per day.
  • For poor blood circulation: 50 mg three times daily.
INTRAMUSCULAR:
  • Healthcare providers give mesoglycan shots to treat cerebrovascular disease, poor blood circulation, and ulcers caused by poor circulation.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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