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How is an enzyme inhibitor used to treat psoriatic arthritis?

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Apremilast (Otezla) is a new kind of drug for long-term inflammation diseases like psoriatic arthritis. It's a pill that works by blocking a specific enzyme, a kind of protein, called PDE-4. That helps to slow other reactions that lead to inflammation.

From: Psoriatic Arthritis Treatment WebMD Medical Reference

SOURCES:

Sharon Mayo, Health Educator, National Psoriasis Foundation

Alice Gottlieb, MD, PhD, Dermatologist-in-Chief, Tufts Medical Center

National Psoriasis Foundation: “Psoriatic Arthritis” “Psoriatic Arthritis Treatments”

American College of Rheumatology: “NSAIDS: Nonsteroidal Anti-Inflammatory Drugs”

American Academy of Dermatology: “Guidelines of care for the management of psoriasis and psoriatic arthritis.”

MedLine Plus Medical Encyclopedia: “Diclofenac and misoprostol.”

Johnston, BL and Conly, JM. , July-August 2006. Canadian Journal of Infectious Diseases and Medical Microbiology

UpToDate: "Treatment of psoriatic arthritis."

Schett, G. , October 2010. Therapeutic Advances in Musculoskeletal Disease

 FDA. “FDA approves Inflectra, a biosimilar to Remicade.” “FDA approves Amjevita, a biosimilar to Humira.”

Reviewed by David Zelman on April 29, 2019

SOURCES:

Sharon Mayo, Health Educator, National Psoriasis Foundation

Alice Gottlieb, MD, PhD, Dermatologist-in-Chief, Tufts Medical Center

National Psoriasis Foundation: “Psoriatic Arthritis” “Psoriatic Arthritis Treatments”

American College of Rheumatology: “NSAIDS: Nonsteroidal Anti-Inflammatory Drugs”

American Academy of Dermatology: “Guidelines of care for the management of psoriasis and psoriatic arthritis.”

MedLine Plus Medical Encyclopedia: “Diclofenac and misoprostol.”

Johnston, BL and Conly, JM. , July-August 2006. Canadian Journal of Infectious Diseases and Medical Microbiology

UpToDate: "Treatment of psoriatic arthritis."

Schett, G. , October 2010. Therapeutic Advances in Musculoskeletal Disease

 FDA. “FDA approves Inflectra, a biosimilar to Remicade.” “FDA approves Amjevita, a biosimilar to Humira.”

Reviewed by David Zelman on April 29, 2019

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What are the side effects of enzyme inhibitors for psoriatic arthritis?

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