Methadone for MAT/Selected Antipsychotics that Prolong QT Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Methadone can affect your heart's rhythm. Your antipsychotic may have the same effect. Both of these medicines depress the central nervous system (CNS).

What might happen:

Taking methadone with other agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening. The risk may be higher if you are taking larger doses of methadone. Concurrent use can result in extreme sleepiness, slowed or difficult breathing, coma, or death.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and how long you have been taking an opioid. Seek medical attention immediately if you develop unusual dizziness or lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness.Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.