Trazodone (> 100 mg)/MAOIs Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of your medicines can increase the level of serotonin in your body.

What might happen:

If serotonin levels get too high you could notice changes in mood, body temperature, blood pressure, how your muscles work, or other physical symptoms. These may be signs of a medical condition called Serotonin Syndrome. Serotonin Syndrome can vary in severity from mild to life threatening.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you experience agitation, restlessness, muscle twitching, tremors, shivering, muscle stiffness, fever, heavy sweating, heart palpitations, confusion, trouble with coordination, or severe diarrhea contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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