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    Atripla

    precautions

    What should I know regarding pregnancy, nursing and administering Atripla to children or the elderly?

    If you are:

    Pregnant:

    FDB Only When Necessary: NO FDA CAT;ART PREG REGISTRY DATA SHOW NO INCREASED RISK FOR MAJOR BIRTH DEFECTS

    Possibly Safe:

    Possibly Safe:

    Nursing:

    Absolute Contraindication: CDC DOES NOT RECOMMEND BREASTFEEDING IN HIV-POSITIVE WOMEN

    Precaution: LIMITED DATA SUGGEST NO KNOWN ADVERSE EFFECTS IN NURSING INFANT

    Absolute Contraindication: CDC DOES NOT RECOMMEND BREASTFEEDING IN HIV-POSITIVE WOMEN.

    An adult over 60:

    management or monitoring precaution: Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.

    management or monitoring precaution: Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.

    Giving Atripla to a child under 12:

    Severe Precaution: Fixed dose combination not appropriate age< 12 years, body weight < 40 kg.

    management or monitoring precaution: Higher incidence of rash and Grade 3 or 4 rash. Consider antihistamine prophylaxis. Risk of lower bone density with tenofovir use in pediatrics. Assess BMD if history of fracture or bone loss.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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