MEKINIST Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • low amount of albumin proteins in the blood
  • anemia
  • low levels of a type of white blood cell called neutrophils
  • a decreased number of lymphocytes in the blood
  • a skin rash
  • erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet

If experienced, these tend to have a Less Severe expression i

  • constipation
  • a skin rash resembling acne
  • muscle pain
  • chills
  • visible water retention
  • fluid retention in the legs, feet, arms or hands
  • decreased appetite
  • nausea
  • vomiting
  • abnormal liver function tests
  • lymphedema, or swelling due to blockage of lymph nodes
  • night sweats

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • low amount of sodium in the blood
  • decreased blood platelets
  • high blood pressure
  • a clot in the lung
  • cardiomyopathy, a disease of the heart muscle
  • heart failure
  • blood clot in a deep vein of the extremities
  • blood clot formation in vein
  • bleeding
  • a type of inflammation of the lung called interstitial pneumonitis
  • inflammation of a hair follicle
  • lung tissue problem
  • cellulitis
  • a type of slow growing skin cancer called a keratoacanthoma
  • cancer of the squamous cells in the skin

If experienced, these tend to have a Less Severe expression i

  • blurred vision
  • dry eye
  • slow heartbeat
  • dry mouth
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • inflammation and infection of nail cuticle
  • itching
  • dry skin
  • dizziness
  • taste impairment
  • intense abdominal pain

RARE side effects

If experienced, these tend to have a Severe expression i

  • sarcoidosis
  • cancer or malignancy
  • detachment of the retina of the eye
  • a blockage of blood vessels in the retina of the eye
  • inflammation of the iris - the colored part of the eyeball
  • inflammation of the uvea of the eye
  • a change in vision
  • inflammation of the large intestine
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • a rupture in the wall of the stomach or intestine
  • macular edema
  • tear of retinal pigment epithelium
  • a second occurrence of melanoma
  • a type of significant allergic skin reaction called DRESS syndrome
  • detachment of retinal pigment epithelium

If experienced, these tend to have a Less Severe expression i

  • a decrease in sharpness of vision called reduced visual acuity

Free RX Coupon

Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

Drug Survey

Are you currently using Mekinist?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.