One ingredient in this combination product, lesinurad, has caused very serious kidney problems. Tell your doctor right away if you notice any signs of kidney problems, such as lower back pain, nausea/vomiting, painful/difficult urination, change in the amount of urine.


This medication is a combination of 2 ingredients: lesinurad and allopurinol. It works by decreasing the amount of uric acid your body makes, and by helping the kidneys get rid of uric acid. Increased uric acid levels can cause gout attacks. This combination medication is used to lower uric acid when allopurinol alone has not worked well enough. This effect helps prevent gout flares/attacks.

How to use Lesinurad 200 Mg-Allopurinol 300 Mg Tablet

See also Warning section.

Read the Medication Guide provided by your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually once daily in the morning with a full glass of water (8 ounces/240 milliliters). Drink plenty of fluids (at least 8 full glasses a day) while taking this medication to help it work better, unless otherwise directed by your doctor.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

If you are switching from taking lesinurad or allopurinol to this combination product, be sure to stop taking the other lesinurad or allopurinol product to avoid taking too much medication(s) and increasing the risk of side effects.

You may have more gout attacks for several months after you start taking this medicine while your body gets rid of extra uric acid. Do not stop taking this medication if you have a gout flare/attack. This medication is not for treating gout attacks. Your doctor may prescribe other medication (including colchicine, NSAIDs such as ibuprofen, naproxen, or indomethacin) to prevent or treat a gout attack while you are taking this medication. Continue to take lesinurad/allopurinol and your prescribed medicines for gout attacks as directed by your doctor. Tell your doctor if your condition does not get better or if it gets worse.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.