SYMFI Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • a feeling of pins and needles on skin
  • high blood levels of the lipase enzyme
  • depression
  • itching
  • a skin rash
  • If experienced, these tend to have a Less Severe expression i

  • a sore throat
  • fever
  • low energy
  • headache
  • cough
  • nausea
  • diarrhea
  • a feeling of general discomfort called malaise
  • an infection of the ear
  • drowsiness
  • difficulty concentrating
  • dizziness
  • difficulty sleeping
  • vomiting
  • abnormal dreams
  • abnormal fat distribution associated with HIV
  • indigestion
  • itching
  • backache
  • pain
  • generalized weakness
  • intense abdominal pain
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • prolonged QT interval on EKG
  • hallucinations
  • high cholesterol
  • pneumonia
  • decreased calcification or density of bone
  • a high alanine transaminase level
  • a high aspartate transaminase level
  • If experienced, these tend to have a Less Severe expression i

  • a stuffy and runny nose
  • indigestion
  • joint pain
  • muscle pain
  • dizziness
  • difficulty sleeping
  • chills
  • decreased appetite
  • vomiting
  • stomach cramps
  • nervousness
  • intense abdominal pain
  • anxious feelings
  • throat irritation
  • weight loss
  • gas
  • excess urination
  • elevation of proteins in the urine
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • increased blood acidity due to high levels of lactic acid
  • anemia
  • enlarged fatty liver
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • swollen lymph nodes
  • an enlarged spleen
  • abnormal liver function tests
  • a significant type of allergic reaction called anaphylaxis
  • pancreatitis
  • pure red cell aplasia
  • mental problems from taking the drug
  • confusion
  • manic behavior
  • delusions
  • paranoia
  • suicidal behavior
  • suicidal thoughts
  • behavioral problems
  • a type of brain function problem called encephalopathy
  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • Guillain-Barre syndrome
  • a change in vision
  • acute liver failure
  • inflammation of the liver called hepatitis
  • acute inflammation of the pancreas
  • drug or chemical-induced sensitivity to sunlight
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • skin rash with sloughing
  • abnormal peeling of skin
  • a skin ulcer
  • hives
  • blistering of the skin
  • fainting
  • seizures
  • fever
  • muscle tremors
  • loss of muscle coordination
  • dysphasia, the inability to arrange words in an understandable way
  • dead skin
  • wheezing
  • trouble breathing
  • a feeling of pins and needles on skin
  • chronic inflammation of muscles in the body called polymyositis
  • a condition that results in overproduction of thyroid hormones called Graves' disease
  • a state of stupor and unresponsiveness called catatonia
  • osteomalacia, or softening of bones
  • low amount of phosphate in the blood
  • low amount of potassium in the blood
  • Fanconi syndrome, a condition of the kidneys resulting in excessive urination, thirst and vomiting
  • a type of kidney inflammation called interstitial nephritis
  • acute kidney failure
  • renal tubular necrosis, a kidney disorder
  • decreased kidney function
  • a type of allergic reaction called angioedema
  • diabetes insipidus with kidney complications
  • If experienced, these tend to have a Less Severe expression i

  • stomatitis, a condition with painful swelling and sores inside the mouth
  • itching
  • hair loss
  • muscle weakness
  • cramps
  • wheezing
  • generalized weakness
  • depersonalization, a disconnection of one's own sense of reality or identity
  • agitation
  • an extreme sense of wellbeing called euphoria
  • ringing in the ears
  • constipation
  • abnormal absorption of food nutrients in the gastrointestinal tract
  • enlarged breasts
  • inflammation of a hair follicle
  • joint pain
  • muscle pain
  • memory loss
  • sensation of spinning or whirling
  • numbness
  • temporary redness of face and neck
  • decreased appetite
  • cough
  • high amount of triglyceride in the blood
  • a disease with shrinking and weaker muscles called myopathy
  • excessive sweating
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.