Does Imatinib MESYLATE Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED IMMUNOSUPPRESSANTS/NADOFARAGENE FIRADENOVEC
  • MODERATE CYP3A4 INHIBITORS/DARIDOREXANT (>25 MG)
  • MODERATE CYP3A4 INHIBITORS/LUMATEPERONE (>21 MG)
  • MODERATE CYP3A4 INHIBITORS/MITAPIVAT (> 20 MG)
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (>50MG)
  • SELECTED CYP3A4 MODERATE INHIBITORS/LURASIDONE (> 80 MG)
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ASUNAPREVIR
  • STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
  • SELECTED IMMUNOSUPPRESSANTS/TALIMOGENE LAHERPAREPVEC
  • MODERATE CYP3A4 INHIBITORS/NALOXEGOL (> 12.5 MG)
  • MODERATE CYP3A4 INHIBITORS/RANOLAZINE (> 500 MG BID)
  • MODERATE CYP3A4 INHIBITORS/AVANAFIL (> 50 MG)
  • STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
  • SELECTED IMMUNOSUPPRESSIVE AGENTS/LIVE VACCINES; LIVE BCG
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/EFALIZUMAB; NATALIZUMAB
  • IMATINIB/SELECTED ANTICOAGULANTS (VIT K ANTAGONISTS)

    • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB/ST. JOHN'S WORT
  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB/STRONG 3A4 INDUCERS
  • SELECTED ORAL BCRP SUBSTRATES/ORAL TEDIZOLID
  • SELECTED BCRP SUBSTRATES/DAROLUTAMIDE
  • SELECTED ANTINEOPLASTIC SYSTEMIC ENZYME INHIBITORS/RIFABUTIN
  • SELECTED BCRP SUBSTRATES/CAPMATINIB
  • ANTINEOPLASTIC SYST ENZYME INH THAT INHIBIT 3A4/CARBAMAZEPIN
  • ANTINEOPLASTIC SYSTEMIC ENZYME INHIBITORS/APALUTAMIDE
  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INH/LUMACAFTOR-IVACAFTOR
  • SELECTED BCRP SUBSTRATES/OTESECONAZOLE
  • MODERATE CYP3A4 INHIBITORS/OMAVELOXOLONE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ELACESTRANT
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/UBLITUXIMAB
  • MODERATE CYP3A4 INHIBITORS/PEXIDARTINIB
  • MODERATE CYP3A4 INHIBITORS/MAVACAMTEN
  • DUAL CYP3A4 & WEAK CYP2D6 INHIBITORS/ELIGLUSTAT
  • MODERATE CYP3A4 INHIBITORS/PACRITINIB
  • MODERATE CYP3A4 INHIBITORS/MOBOCERTINIB
  • SELECTED INHIBITORS OF BCRP WITH MYELOSUPPRESSION/CLADRIBINE
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/SIPONIMOD
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/OZANIMOD
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/FINGOLIMOD
  • STRONG AND MODERATE CYP3A4 INHIBITORS/FEXINIDAZOLE
  • MYELOSUPPRESSIVES; IMMUNOMODULATORS/SODIUM IODIDE I 131
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/FILGOTINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB
  • SELECTED MODERATE CYP3A4 INHIBITORS/ALPRAZOLAM
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/PONESIMOD
  • SELECTED IMMUNOSUPPRESSANTS/LEFLUNOMIDE; TERIFLUNOMIDE
  • MODERATE CYP3A4 INHIBITORS/VOCLOSPORIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/BARICITINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/INEBILIZUMAB
  • MODERATE CYP3A4 INHIBITORS/SELPERCATINIB
  • MODERATE CYP3A4 INHIBITORS/PEXIDARTINIB (200 MG)
  • STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB
  • MODERATE CYP3A4 INHIBITORS/TAZEMETOSTAT
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LEMBOREXANT
  • MODERATE CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/UPADACITINIB
  • MODERATE CYP3A4 INHIBITORS/ENTRECTINIB
  • MODERATE CYP3A4 INHIBITORS/BRIGATINIB
  • SELECTED ORAL INHIBITORS OF BCRP/TALAZOPARIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ENCORAFENIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
  • STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
  • MODERATE CYP3A4 INHIBITORS/VENETOCLAX
  • IMMUNOSUPPRES;IMMUNOMODUL/SELECTED MULTIPLE SCLEROSIS AGENTS
  • MODERATE CYP3A4 INHIBITORS/NALOXEGOL (<= 12.5 MG)
  • MODERATE CYP3A4 INHIBITORS/COBIMETINIB; OLAPARIB; SONIDEGIB
  • MODERATE CYP3A4 INHIBITORS/SUVOREXANT (> 10 MG)
  • MODERATE CYP3A4 INHIBITORS/ERGOT ALKALOIDS
  • SELECTED MODERATE CYP3A4 INHIBITORS/PIMOZIDE
  • STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
  • STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
  • STRONG AND MODERATE CYP3A4 INHIBITORS/BOSENTAN
  • SELECTED MYELOSUPPRESSIVE AGENTS/CLOZAPINE
  • MODERATE CYP3A4 INHIBITORS/BOSUTINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
  • SELECTED MYELOSUPPRESSIVE AGENTS/DEFERIPRONE
  • MODERATE CYP3A4 INHIBITORS/COLCHICINE
  • MODERATE CYP3A4 INHIBITORS/TOLVAPTAN
  • MODERATE CYP3A4 INHIBITORS/IVABRADINE
  • SELECTED MODERATE CYP3A4 INHIBITORS/EPLERENONE

    • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • GEFITINIB; IMATINIB/SLT AZOLE ANTIFUNGALS; LEVOKETOCONAZOLE
  • SELECTED BCRP SUBSTRATES/SAFINAMIDE
  • BCRP OR OATP1B1 SUBSTRATES/ELTROMBOPAG
  • DASATINIB; IMATINIB/METHOTREXATE (ONCOLOGY-INJECTION)
  • MODERATE CYP3A4 INHIBITORS/LAROTRECTINIB
  • MODERATE CYP3A4 INHIBITORS/LUMATEPERONE (<=21 MG)
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/SARILUMAB; TOCILIZUMAB
  • MODERATE CYP3A4 INHIBITORS/MITAPIVAT (<= 20 MG)
  • MODERATE CYP3A4 INHIBITORS/DARIDOREXANT (<=25 MG)
  • SLT MODERATE AND WEAK CYP3A4 INHIBIT/SIROLIMUS PROTEIN-BOUND
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/COVID-19 VACCINES
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/USTEKINUMAB
  • MODERATE CYP3A4 INHIBITORS/RIMEGEPANT
  • MODERATE CYP3A4 INHIBITORS/AVAPRITINIB
  • MODERATE CYP3A4 INHIBITORS/UBROGEPANT
  • MODERATE AND WEAK CYP3A4 INHIBITORS/TACROLIMUS
  • MODERATE CYP3A4 INHIBITORS/ZANUBRUTINIB
  • MODERATE CYP3A4 INHIBITORS/ORAL LEFAMULIN
  • SELECTED CYP3A4 MODERATE INHIBITORS/LURASIDONE (<= 80 MG)
  • MODERATE CYP3A4 INHIBITORS/ABEMACICLIB
  • SELECTED MODERATE CYP3A4 INHIBITORS/IVOSIDENIB
  • MODERATE CYP3A4 INHIBITORS/CABERGOLINE
  • SELECTED MODERATE CYP3A4 INHIBITORS/ACALABRUTINIB
  • MODERATE CYP3A4 INHIBITORS/QUETIAPINE
  • MODERATE CYP3A4 INHIBITORS/BROMOCRIPTINE
  • MODERATE CYP3A4 INHIBITORS/BREXPIPRAZOLE
  • MODERATE CYP3A4 INHIBITORS/SUVOREXANT (<= 10 MG)
  • IMATINIB;SUNITINIB/THYROID PREPARATIONS
  • MODERATE CYP3A4 INHIBITORS/AVANAFIL (<= 50 MG)
  • MODERATE CYP3A4 INHIBITORS/IBRUTINIB
  • SELECTED CYP2D6 INHIBITORS/METOPROLOL
  • SELECTED MODERATE CYP3A4 INHIBITORS/SELECTED OPIOIDS
  • MODERATE CYP3A4; P-GP INHIBITORS/EVEROLIMUS
  • SELECTED WEAK CYP2D6 INHIBITORS/TAMOXIFEN
  • MODERATE CYP3A4 INHIBITORS/RANOLAZINE (<=500 MG BID)
  • IMATINIB/LOVASTATIN; SIMVASTATIN
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (<=50MG)
    • Full Drug Information

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.