Indomethacin/Diflunisal Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Diflunisal may prevent your intestine, liver, and kidneys from processing your indomethacin.

What might happen:

The amount of indomethacin in your blood may increase and cause side effects, including bleeding.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Let your doctor know right away if you have any unusual bleeding, including bleeding from your gums, nosebleeds, unusual bruising, dark stools, or if you vomit blood or material that looks like coffee grounds, or if you have any abdominal pain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Eriksson LO, Wahlin-Boll E, Liedholm H, Seideman P, Melander A. Influence of chronic diflunisal treatment on the plasma levels, metabolism and excretion of indomethacin. Eur J Clin Pharmacol 1989;37(1):7-15.
  • 2.Van Hecken A, Verbesselt R, Tjandra-Maga TB, De Schepper PJ. Pharmacokinetic interaction between indomethacin and diflunisal. Eur J Clin Pharmacol 1989;36(5):507-12.
  • 3.Mano Y, Usui T, Kamimura H. In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humans. Biopharm Drug Dispos 2006 Sep;27(6):267-73.
  • 4.Indocin (indomethacin) US prescribing information. Merck & Co., Inc. March, 2019.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.