Black Cohosh a Bust for Hot Flashes

Millions of women have taken black cohosh to reduce hot flashes and other menopause-related symptoms, but the most rigorous study of the herbal supplement ever conducted shows no evidence that it works.

From the WebMD Archives

Dec. 18, 2006 -- Millions of women have taken black cohosh to reduce hot flashes and other menopause-related symptoms, but the most rigorous study of the herbal supplement ever conducted shows no evidence that it works.

The federally funded trial was designed to compare black cohosh to other herbal supplements, traditional hormone therapy, and placebo treatment for menopausal symptoms.

Hormone therapy was the only treatment that clearly reduced hot flashes, night sweats, and other related symptoms.

The study appears in the Dec. 19 issue of the journal Annals of Internal Medicine.

"Our finding that black cohosh did not work will be disappointing news to many women," researcher Katherine M. Newton, PhD, tells WebMD. "It would be nice to find a clearly effective alternative to hormone therapy."

Looking for Alternatives

Most women experience hot flashes and related symptoms around the time of menopause, which typically occurs between ages 45 and 55.

Hormone therapy involving estrogen or estrogen plus progestin is very effective for reducing hot flashes, but concerns about safety have caused millions of women to abandon the treatment.

Those concerns appeared to be bolstered late last week with the news of a dramatic drop in breast cancers among American women.

Although the reason for the drop is not yet clear, many experts speculate that it is related to the decline in hormone use following the 2002 publication of the Women's Health Initiative study, which found an increase in both breast cancers and heart problems among users.

Many symptomatic women turned to black cohosh and other herbal supplements when they stopped taking hormones, but few well-designed clinical trials have been done evaluating the effectiveness of these products.

Continued

Studying Treatments for Menopause Symptoms

In an effort to address this, Newton and colleagues with the Seattle-based health care system Group Health Cooperative recruited 351 menopausal and newly postmenopausal women for their study.

The women were between the ages of 45 and 55 when they entered the trial, and all were experiencing at least two menopause-related symptoms a day.

Without knowing which treatment they were getting, all of the women took one of five therapies for a year. The treatments were:

  • Black cohosh alone (160 milligrams daily)
  • A combination herbal supplement that included 200 milligrams of black cohosh daily, plus alfalfa, boron, dong quai, ginseng, and other herbal ingredients
  • A combination herbal supplement that did not include black cohosh but did include recommendations to increase the consumption of soy-based foods
  • Traditional hormone therapy
  • Placebo

The researchers found no significant difference in the number of daily hot flashes experienced by women on any of the treatments, with the exception of hormone therapy.

Women taking herbal supplements had an average of half a hot flash a day less than women taking placebo -- an amount not considered significant. By comparison, the women on hormone therapy had about four fewer hot flashes a day.

What Can You Do?

So what can women who don't want to take hormone therapy do to avoid hot flashes? There is some evidence that certain antidepressants help some. And lifestyle measures can make a big difference, Newton says. These include:

  • Dressing in layers so that you can take off clothing when you feel a hot flash coming on.
  • Keeping ice water or a fan nearby.
  • Sleeping in a cool bedroom.
  • Avoiding triggers, which may include spicy food, alcohol, or hot beverages.

Women who feel they need hormone therapy should take it in the lowest effective dosage for the shortest time necessary, says Sherry Sherman, PhD, of the National Institute on Aging (NIA).

"It may be that hormone therapy is more risky for some women than for others," she tells WebMD. "We would love to be able to identify those women who can safely take estrogen and those who shouldn't."

Continued

Those custom compounded hormones that have been the subject of much recent media attention were not evaluated in the new study.

Bioidentical hormones are being touted by some, including actress and author Suzanne Somers, as being safer alternatives to traditional hormone therapy.

But Sherman says if the hormones are as effective as traditional hormones, they probably carry the same risks.

Sherman is director of clinical aging and reproductive hormone research at NIA.

"Just because you take a drug and don't know the risks doesn't mean those risks don't exist," she says.

WebMD Health News Reviewed by Louise Chang, MD on December 18, 2006

Sources

SOURCES: Newton, K.M. Annals of Internal Medicine, Dec. 19, 2006; vol 145: pp 869-879. Katherine M. Newton, PhD, associate director of research, Group Health Center for Health Studies, Seattle. Sherry Sherman, PhD, director, clinical aging and reproductive hormone research, National Institute on Aging, National Institutes of Health, Bethesda, Md.

© 2006 WebMD, Inc. All rights reserved.

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