3',5,7-trihydroxy-4'-methoxyflavone-7-rhamnoglucoside, Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïde d'Agrume, Bioflavonoïdes d'Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïde, Concentré de Bioflavonoïde, Diosmetin, Diosmetin 7-O-rutinoside, Diosmina, Diosmine, Extrait de Bioflavonoïde, Extrait de Bioflavonoïde d'Agrume, Flavonoid, Flavonoïde, Micronised Purified Flavonoid Fraction.


Overview Information

Diosmin is a chemical in some plants. It's found mainly in citrus fruits.

Diosmin is most often used for hemorrhoids and leg sores caused by poor blood flow. It's also used for other conditions, but there's no strong evidence to support these uses.

Diosmin is often taken with hesperidin. Hesperidin is another plant chemical.

How does it work?

Diosmin might work by reducing swelling (inflammation) and restoring normal vein function. Diosmin also seems to have antioxidant effects.


Uses & Effectiveness?

Possibly Effective for

  • Hemorrhoids. Taking diosmin in high doses along with hesperidin seems to reduce symptoms of hemorrhoids. Taking diosmin in lower doses along with hesperidin plus troxerutin also seems to help. Taking diosmin in lower doses along with hesperidin seems to help prevent hemorrhoids from coming back.
  • Leg sore caused by weak blood circulation (venous leg ulcer). Taking diosmin with hesperidin and using compression dressing seems to help heal leg ulcers caused by poor circulation.

Insufficient Evidence for

  • Back pain. Early research shows that taking diosmin for at least 8 weeks decreases pain and might reduce the need to use rescue pain medicine similarly to receiving the standard medications mannitol and dexamethasone.
  • Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Some research shows that taking diosmin may help to reduce pain by a small amount in people with CVI. But not all research agrees.
  • Swelling in the arms or legs caused by damage to the lymph system (lymphedema). Taking diosmin with hesperidin might not reduce swelling of the arms following surgery for breast cancer.
  • Minor bleeding.
  • Bleeding gums.
  • Bleeding (hemorrhage) in the eye.
  • Preventing damage to the liver.
  • Varicose veins.
  • Other conditions.
More evidence is needed to rate the effectiveness of diosmin for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Diosmin is POSSIBLY SAFE for most people when used by mouth short-term. It can cause some side effects such as stomach pain, diarrhea, dizziness, headache, skin redness and hives, muscle pain, blood problems, and altered heart rate.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of diosmin during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Diosmin might make bleeding disorders worse. If you have a bleeding disorder, don't use diosmin.



We currently have no information for DIOSMIN Interactions.



Diosmin is often taken in combination with hesperidin.

The following doses have been studied in scientific research:



  • For hemorrhoids: For treating hemorrhoids, 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days followed by 900 mg of diosmin and 100 mg of hesperidin twice daily for 3 days has been used. Also, 300 mg of diosmin, 300 mg of troxerutin, and 300 mg of hesperidin three times daily for 3 days, followed by two times daily for 2 days, and then once daily for 7 days has been used. Thereafter, 300 mg of diosmin, 300 mg of troxerutin, and 100 mg of hesperidin has been used daily for one month. Some researchers also try 600 mg of diosmin three times daily for 4 days, followed by 300 mg twice daily for 10 days, in combination with 11 grams of psyllium daily. However, this lower diosmin dose does not seem to be as effective.
  • For leg ulcers caused by poor circulation (venous stasis ulcers): 900 mg of diosmin plus 100 mg of hesperidin daily has been used for up to 2 months.

View References


  • Agir MS, Eraslan G. The effect of diosmin against liver damage caused by cadmium in rats. J Food Biochem. 2019;43(9):e12966. View abstract.
  • Attia TM. Efficacy and Safety of Daflon in the Treatment of Idiopathic Epistaxis. Am J Rhinol Allergy. 2019;33(1):62-68. View abstract.
  • Bedada SK, Boga PK, Kotakonda HK. The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers. Xenobiotica. 2017;47(3):230-35. View abstract.
  • Bedada SK, Boga PK. Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects. Xenobiotica. 2017;47(10):879-84. View abstract.
  • Bedada SK, Neerati P. Modulation of CYP3A enzyme activity by diosmin and its consequence on carbamazepine pharmacokinetics in rats. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(2):115-21.View abstract.
  • Bozdag M, Eraslan G. The effect of diosmin against lead exposure in rats. Naunyn Schmiedebergs Arch Pharmacol. 2019. View abstract.
  • Burkina V, Zlabek V, Halsne R, Ropstad E, Zamaratskaia G. In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish. Biochem Pharmacol. 2016;110-111:109-16 View abstract.
  • Cacchio A, Prencipe R, Bertone M, et al. Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren) in addition to complex decongestive therapy on management of breast cancer-related lymphedema. Support Care Cancer. 2019;27(4):1471-1480. View abstract.
  • Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology 1994;45:566-73. View abstract.
  • Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr 1999;70:491-9. View abstract.
  • Danielsson G, Jungbeck C, Peterson K, Norgren L. A randomised controlled trial of micronized purified flavonoid fraction vs placebo in patients with chronic venous disease. Eur J Vasc Endovasc Surg. 2002;23(1):73-6. View abstract.
  • Di Carlo G, Mascolo N, Izzo AA, Capasso F. Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci 1999;65:337-53. View abstract.
  • Feldo M, Wójciak-Kosior M, Sowa I, et al. Effect of Diosmin Administration in Patients with Chronic Venous Disorders on Selected Factors Affecting Angiogenesis. Molecules. 2019;24(18). pii: E3316. View abstract.
  • Giannini I, Amato A, Basso L, Tricomi N, Marranci M, Pecorella G, Tafuri S, Pennisi D, Altomare DF. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015 Jun;19(6):339-45. View abstract.
  • Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology 1997;48:77-85.. View abstract.
  • Kakkos SK, Nicolaides AN. Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials. Int Angiol. 2018;37(2):143-154. View abstract.
  • Kumar RM, Van Gompel JJ, Bower R, Rabinstein AA. Spontaneous intraventricular hemorrhage associated with prolonged diosmin therapy. Neurocrit Care. 2011 Jun;14(3):438-40. View abstract.
  • Middleton E. Some biological properties of plant flavonoids. Ann Allergy 1988;61:53-7. View abstract.
  • Milano G, Leone S, Fucile C, Zuccoli ML, Stimamiglio A, Martelli A, Mattioli F. Uncommon serum creatine phosphokinase and lactic dehydrogenase increase during diosmin therapy: two case reports. J Med Case Rep. 2014 Jun 16;8:194. View abstract.
  • Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surgery 2000;87:868-72. View abstract.
  • Pecking AP, Fevrier B, Wargon C, Pillion G. Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer). Angiology 1997;48:93-8.. View abstract.
  • Poór M, Boda G, Mohos V, et al. Pharmacokinetic interaction of diosmetin and silibinin with other drugs: Inhibition of CYP2C9-mediated biotransformation and displacement from serum albumin. Biomed Pharmacother. 2018;102:912-921. View abstract.
  • Rabe E, Agus GB, Roztocil K. Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: from a prospective randomized trial. Int Angiol. 2015;34(5):428-36. View abstract.
  • Rajnarayana K, Venkatesham A, Krishna DR. Bioavailability of diclofenac sodium after pretreatment with diosmin in healthy volunteers. Drug Metabol Drug Interact. 2007;22(2-3):165-74. View abstract.
  • Rajnarayana K, Venkatesham A, Nagulu M, Srinivas M, Krishna DR. Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers. Drug Metabol Drug Interact. 2008;23(3-4):311-21. View abstract.
  • Russo R, Chandradhara D, De Tommasi N. Comparative bioavailability of two diosmin formulations after oral administration to healthy volunteers. Molecules. 2018;23(9). pii: E2174. View abstract.
  • Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med 2012;52(1):182-90. View abstract.
  • Thanapongsathorn W, Vajrabukka T. Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids. Dis Colon Rectum 1992;35:1085-8. View abstract.
  • Villa P, Cova D, De Francesco L, et al. Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Toxicology 1992;73:179-89. View abstract.
  • Wang Y, Fang X, Ye L, Li Y, Shi H, Cao Y. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. Biomed Res Int. 2017;2017:6875968. View abstract.
  • Yoo HH, Lee M, Chung HJ, Lee SK, Kim DH. Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J Agric Food Chem. 2007 Sep 5;55(18):7620-5. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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