Inulin is a starchy substance found in a wide variety of fruits, vegetables, and herbs, including wheat, onions, bananas, leeks, artichokes, and asparagus. The inulin that is used in supplements most commonly comes from soaking chicory roots in hot water.
People commonly use inulin by mouth for weight loss, constipation, and diabetes. It's also used for high blood fats, including cholesterol and triglycerides, and many other conditions, but there is no good scientific evidence to support most of these uses.
Uses & Effectiveness ?
Possibly Effective for
- Constipation. Taking inulin by mouth seems to help relieve constipation in some children and adults. It increases the number of stools by up to about one per week. But it might not reduce discomfort.
- Diabetes. Taking inulin by mouth along with antidiabetes drugs might improve blood sugar levels in some people with diabetes, short-term. But it's not clear if it helps long-term.
- Obesity. Taking inulin by mouth might increase short-term weight loss. But it's not clear if it helps with long-term weight loss or weight maintenance in people who are overweight or obese.
Special Precautions and Warnings
Children: Inulin is likely safe in children in the amounts found in foods. It is possibly safe for children when taken by mouth as a medicine, short-term. Inulin is possibly safe when used as part of infant formula, short-term.
Medications for diabetes (Antidiabetes drugs) interacts with INULIN
Inulin might lower blood sugar levels. Taking inulin along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Be watchful with this combination
Abrams SA, Griffin IJ. Calcium absorption is increased in adolescent girls receiving enriched inulin. World Congress of Pediatric Gastroenterology, Hepatology, & Nutrition, Boston, MA, August 5-9, 2000: Abstract 821.
Alptekin IM, Çakiroglu FP, Örmeci N. Effects of ß-glucan and inulin consumption on postprandial appetite, energy intake and food consumption in healthy females: A randomized controlled trial. Nutr Health 2021. View abstract.
Becerril-Alarcón Y, Campos-Gómez S, Valdez-Andrade JJ, et al. Inulin supplementation reduces systolic blood pressure in women with breast cancer undergoing neoadjuvant chemotherapy. Cardiovasc Ther. 2019;2019:5707150. View abstract.
Birkeland E, Gharagozlian S, Birkeland KI, Holm OKS, Thorsby PM, Aas AM. Effect of inulin-type fructans on appetite in patients with type 2 diabetes: a randomised controlled crossover trial. J Nutr Sci 2021;10:e72. View abstract.
Biruete A, Cross TL, Allen JM, et al. Effect of Dietary Inulin Supplementation on the Gut Microbiota Composition and Derived Metabolites of Individuals Undergoing Hemodialysis: A Pilot Study. J Ren Nutr 2021;31(5):512-522. View abstract.
Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. View abstract.
Bosscher D, Van Caillie-Bertrand M, Van Cauwenbergh R, Deelstra H. Availabilities of calcium, iron, and zinc from dairy infant formulas is affected by soluble dietary fibers and modified starch fractions. Nutrition. 2003;19(7-8):641-5. View abstract.
Brighenti F, Casiraghi MC, Canzi E, Ferrari A. Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr 1999;53:726-33.. View abstract.
Brighenti F. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. J Nutr. 2007 Nov;137(11 Suppl):2552S-2556S. doi: 10.1093/jn/137.11.2552S. View abstract.
Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res 2018;62(24):e1800865. View abstract.
Chong CYL, Orr D, Plank LD, Vatanen T, O'Sullivan JM, Murphy R. Randomised double-blind placebo-controlled trial of inulin with metronidazole in non-alcoholic fatty liver disease (NAFLD). Nutrients. 2020;12(4):E937. View abstract.
Closa-Monasterolo R, Ferré N, Castillejo-DeVillasante G, et al. The use of inulin-type fructans improves stool consistency in constipated children. A randomised clinical trial: pilot study. Int J Food Sci Nutr. 2017;68(5):587-594. View abstract.
Closa-Monasterolo R, Gispert-Llaurado M, Luque V, et al. Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial. Clin Nutr 2013;32(6):918-27. View abstract.
Collado Yurrita L, San Mauro Martín I, Ciudad-Cabañas MJ, Calle-Purón ME, Hernández Cabria M. Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials. Nutr Hosp 2014;30(2):244-52. View abstract.
Coudray C, Rambeau M, Feillet-Coudray C, et al. Dietary inulin intake and age can significantly affect intestinal absorption of calcium and magnesium in rats: a stable isotope approach. Nutr J. 2005;4:29. View abstract.
Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. View abstract.
Davidson MH, Maki KC, Synecki C, et al. Effects of dietary inulin on serum lipids in men and women with hypercholesterolemia. Nutr Res 1998;18:503-17.
Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. View abstract.
Drabinska N, Krupa-Kozak U, Abramowicz P, Jarocka-Cyrta E. Beneficial effect of oligofructose-enriched inulin on vitamin D and E status in children with celiac disease on a long-term gluten-free diet: a preliminary randomized, placebo-controlled nutritional intervention study. Nutrients 2018;10(11). pii: E1768. View abstract.
Dysseler P, Hoffem D. Inulin, an alternative dietary fibre. Properties and quantitative analysis. Eur J Clin Nutr 1995;49:S145-52.
Ferus K, Drabinska N, Krupa-Kozak U, Jarocka-Cyrta E. A randomized, placebo-controlled, pilot clinical trial to evaluate the effect of supplementation with prebiotic Synergy 1 on iron homeostasis in children and adolescents with celiac disease treated with a gluten-free diet. Nutrients 2018;10(11). pii: E1818. View abstract.
Gay-Crosier F, Schreiber G, Hauser C. Anaphylaxis from inulin in vegetables and processed food. N Engl J Med 2000;342:1372. View abstract.
Gibson GR, Beatty ER, Wang X, Cummings JH. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 1995;108:975-82.. View abstract.
Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. View abstract.
Harrold JA, Hughes GM, O'Shiel K, et al. Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice. Appetite 2013;62:84-90. View abstract.
Heap S, Ingram J, Law M, Tucker AJ, Wright AJ. Eight-day consumption of inulin added to a yogurt breakfast lowers postprandial appetite ratings but not energy intakes in young healthy females: a randomised controlled trial. Br J Nutr 2016;115(2):262-70. View abstract.
Hess AL, Benítez-Páez A, Blædel T, et al.; The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention. Eur J Nutr. 2020;59(6):2507-2524. View abstract.
Hoeger WW, Harris C, Long EM, Hopkins DR. Four-week supplementation with a natural dietary compound produces favorable changes in body composition. Adv Ther 1998;15:305-14. View abstract.
Kleessen B, Sykura B, Zunft HJ, Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 1997;65:1397-402.. View abstract.
Kok N, Roberfroid M, Delzenne N. Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism. Metabolism 1996;45:1547-50. View abstract.
Lai S, Mazzaferro S, Muscaritoli M, et al. Prebiotic therapy with inulin associated with low protein diet in chronic kidney disease patients: evaluation of nutritional, cardiovascular and psychocognitive parameters. Toxins (Basel). 2020 Jun 9;12(6):381. doi: 10.3390/toxins12060381. View abstract.
Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. View abstract.
Lightowler H, Thondre S, Holz A, Theis S. Replacement of glycaemic carbohydrates by inulin-type fructans from chicory (oligofructose, inulin) reduces the postprandial blood glucose and insulin response to foods: report of two double-blind, randomized, controlled trials. Eur J Nutr 2018;57(3):1259-68. View abstract.
Liu F, Prabhakar M, Ju J, Long H, Zhou HW. Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2017;71(1):9-20. View abstract.
Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. View abstract.
Menne E, Guggenbuhl N, Roberfroid M. Fn-type chicory inulin hydrolysate has a prebiotic effect in humans. J Nutr 2000;130:1197-9. View abstract.
Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. View abstract.
Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. View abstract.
Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. View abstract.
Neumer F, Urraca O, Alonso J, et al. Long-Term Safety and Efficacy of Prebiotic Enriched Infant Formula-A Randomized Controlled Trial. Nutrients 2021;13(4):1276. View abstract.
Nicolucci AC, Hume MP, Martínez I, Mayengbam S, Walter J, Reimer RA. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 2017;153(3):711-722. View abstract.
Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. View abstract.
Piazza C, Privitera MG, Melilli B, et al. Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal women. Am J Clin Nutr 2007;86(3):775-80. View abstract.
Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. View abstract.
Roberfroid MB, Van Loo JA, Gibson GR. The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr 1998;128:11-9. View abstract.
Roberfroid MB. Functional effects of food components and the gastrointestinal system: chicory fructo-oligosaccharides. Nutr Rev 1996;54:S38-42. View abstract.
Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. View abstract.
Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23(2):75-81. View abstract.
Szajewska H, Weizman Z, Abu-Zekry M, et al.; ESPGHAN Working Group on Probiotics and Prebiotics. Inulin and fructo-oligosaccharides for the prevention of antibiotic-associated diarrhea in children: report by the ESPGHAN Working Group on Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2012;54(6):828-9. View abstract.
Teuri U, Karkkainen M, Lamberg-Allardt C, Korpela R. Addition of inulin to breakfast does not acutely affect serum ionized calcium and parathyroid hormone concentrations. Ann Nutr Metab 1999;43:356-64.. View abstract.
van der Beek CM, Canfora EE, Kip AM, et al. The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men. Metabolism 2018;87:25-35. View abstract.
Wang X, Wang T, Zhang Q, Xu L, Xiao X. Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes. Int J Endocrinol 2021;2021:5579369. View abstract.
Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. View abstract.
Yang HY, Yang SC, Chao JC, Chen JR. Beneficial effects of catechin-rich green tea and inulin on the body composition of overweight adults. Br J Nutr 2012;107(5):749-54. View abstract.
Zhang W, Tang Y, Huang J, Yang Y, Yang Q, Hu H. Efficacy of inulin supplementation in improving insulin control, HbA1c and HOMA-IR in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. J Clin Biochem Nutr 2020;66(3):176-83. doi: 10.3164/jcbn.19-103. View abstract.
Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf) 2022. View abstract.
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