Ge, X., Fares, F. A., and Yannai, S. Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax. Anticancer Res. 1999;19(4B):3199-3203. View abstract.
Gong, Y., Sohn, H., Xue, L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Cancer Res. 5-1-2006;66(9):4880-4887. View abstract.
Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.Res. 2010;2(4):402-411. View abstract.
Hong, C., Firestone, G. L., and Bjeldanes, L. F. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. Biochem.Pharmacol. 3-15-2002;63(6):1085-1097. View abstract.
Hong, C., Kim, H. A., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Carcinogenesis 2002;23(8):1297-1305. View abstract.
Hsu, E. L., Chen, N., Westbrook, A., Wang, F., Zhang, R., Taylor, R. T., and Hankinson, O. CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. Cancer Lett. 6-28-2008;265(1):113-123. View abstract.
Hsu, J. C., Zhang, J., Dev, A., Wing, A., Bjeldanes, L. F., and Firestone, G. L. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. Carcinogenesis 2005;26(11):1896-1904. View abstract.
Ichite, N., Chougule, M. B., Jackson, T., Fulzele, S. V., Safe, S., and Singh, M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin.Cancer Res. 1-15-2009;15(2):543-552. View abstract.
Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. View abstract.
Jellinck, P. H., Makin, H. L., Sepkovic, D. W., and Bradlow, H. L. Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes. J.Steroid Biochem.Mol.Biol. 1993;46(6):791-798. View abstract.
Jin, Y., Zou, X., and Feng, X. 3,3'-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells. Anticancer Drugs 2010;21(9):814-822. [RETRACTED]. View abstract.
Kandala, P. K. and Srivastava, S. K. Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 2010;78(2):297-309. View abstract.
Kassie, F., Anderson, L. B., Scherber, R., Yu, N., Lahti, D., Upadhyaya, P., and Hecht, S. S. Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. Cancer Res. 7-1-2007;67(13):6502-6511. View abstract.
Kassie, F., Melkamu, T., Endalew, A., Upadhyaya, P., Luo, X., and Hecht, S. S. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis 2010;31(9):1634-1641. View abstract.
Kim, E. J., Park, H., Kim, J., and Park, J. H. 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. Mol.Carcinog. 2010;49(7):672-683. View abstract.
Kim, E. J., Park, S. Y., Shin, H. K., Kwon, D. Y., Surh, Y. J., and Park, J. H. Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. J.Nutr. 2007;137(1):31-36. View abstract.
Kim, E. J., Shin, M., Park, H., Hong, J. E., Shin, H. K., Kim, J., Kwon, D. Y., and Park, J. H. Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. J.Nutr. 2009;139(12):2373-2379. View abstract.
Kim, Y. H., Kwon, H. S., Kim, D. H., Shin, E. K., Kang, Y. H., Park, J. H., Shin, H. K., and Kim, J. K. 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Inflamm.Bowel.Dis. 2009;15(8):1164-1173. View abstract.
Kong, D., Li, Y., Wang, Z., Banerjee, S., and Sarkar, F. H. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 4-1-2007;67(7):3310-3319. [RETRACTED]. View abstract.
Sugiyama, T. and Sadzuka, Y. Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents. Biochim.Biophys.Acta 12-5-2003;1653(2):47-59. View abstract.
Sugiyama, T. and Sadzuka, Y. Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level. Cancer Lett. 8-30-2004;212(2):177-184. View abstract.
Sugiyama, T., Sadzuka, Y., Nagasawa, K., Ohnishi, N., Yokoyama, T., and Sonobe, T. Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin. Jpn J Cancer Res 1999;90(7):775-780. View abstract.
Terashima, T., Takido, J., and Yokogoshi, H. Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine. Biosci.Biotechnol.Biochem. 1999;63(4):615-618. View abstract.
Yang, Q. S., Xu, P. X., Li, Y. H., Jiang, S., Zhang, X., and Xue, M. [Effects of theanine and houpu extract in 7-day chick social separation-stress procedure]. Zhongguo Zhong.Yao Za Zhi. 2007;32(19):2040-2043. View abstract.
Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. View abstract.
Camfield DA, Stough C, Farrimond J, Scholey AB. Actue effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. 2014;72(8):507-522. View abstract.
Dodd FL, Kennedy DO, Riby LM, Haskell-Ramsay CF. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology. 2015;232(14):2563-2576. View abstract.
Einöther SJ, Martens VE, Rycroft JA, De Bruin EA. L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite 2010;54(2):406-9. View abstract.
Foxe JJ, et al. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology. 2012;62(7):2320-2327. View abstract.
Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev Med 1992;21:334-50. View abstract.
Hamaguchi R, Tsuchiya T, Miyata G, et al. Efficacy of oral administration of cystine and theanine in colorectal cancer patients undergoing capecitabine-based adjuvant chemotherapy after surgery: a multi-institutional, randomized, double-blinded, placebo-controlled, phase II trial (JORTC-CAM03). Support Care Cancer. 2019. View abstract.
Hidese S, Ogawa S, Ota M, et al. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial. Nutrients. 2019;11(10). pii: E2362. View abstract.
Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9. View abstract.
Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci 2017;20(6):369-77. View abstract.
Kahathuduwa CN, Wakefield S, West BD, et al. Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT. Sci Rep 2020;10(1):13072. View abstract.
Kakuda T, Nozawa A, Unno T, et al. Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat. Biosci Biotechnol Biochem 2000;64:287-93. View abstract.
Kakuda T, Yanase H, Utsunomiya K, et al. Protective effect of gamma-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils. Neurosci Lett 2000;289:189-92. View abstract.
Kardashev A, Ratner Y, Ritsner MS.Add-on pregnenolone with L-theanine to antipsychotic therapy relieves negative and anxiety symptoms of schizophrenia: an 8-week, randomized, double-blind, placebo-controlled trial. Clin Schizophr Relat Psychoses. 2018;12(1):31-41. doi: 10.3371/CSRP.KARA.070415. View abstract.
Kawada S, Kobayashi K, Ohtani M, Fukusaki C. Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men. J Strength Cond Res 2010;24(3):846-51. View abstract.
Kelly SP, Gomez-Ramirez M, Montesi JL, Foxe JJ. L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. J Nutr 2008;138(8):1572S-1577S. View abstract.
Kimura R, Murata T. Effect of theanine on norepinephrine and serotonin levels in rat brain. Chem Pharm Bull 1986;34:3053-57.
Lin L, Zeng L, Liu A, et al. L-theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways. Food Funct. 2020;11(2):1798-1809. View abstract.
Lu K, Gray MA, Oliver C, et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol 2004;19:457-65. View abstract.
Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-354. View abstract.
Miodownik C, Maayan R, Ratner Y, et al. Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients. Clin Neuropharmacol 2011;34(4):155-60. View abstract.
Miyachi T, et al. Perioperative oral administration of cystine and theanine enhances recovery after distal gastrectomy: a prospective randomized trial. JPEN. 2013;37(3):384-391. View abstract.
Murakami S, Kurihara S, Koikawa N, et al. Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial. Biosci Biotechnol Biochem 2009;73(4):817-21. View abstract.
Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci 2008;11(4):193-8. View abstract.
Park SK, Jung IC, Lee WK, et al. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food 2011;14(4):334-43. View abstract.
Ritsner MS, Miodownik C, Ratner Y, et al. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry 2011;72(1):34-42. View abstract.
Sadzuka Y, Sugiyama T, Miyagishima A, et al. The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin. Cancer Lett 1996;105:203-9. View abstract.
Sadzuka Y, Sugiyama T, Sonobe T. Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol Lett 2000;114:155-62. View abstract.
Sadzuka Y, Sugiyama T, Sonobe T. Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea. Cancer Lett 2000;158:119-24. View abstract.
Sakato Y. The chemical constituents of tea: III. A new amide theanine. Nippon Nogei Kagakukaishi 1949;23:262-267.
Sarris J, Byrne GJ, Cribb L, et al. L-theanine in the adjunctive treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled trial. J Psych Res 2019;110:31-7. View abtract.
Scheid L, et al. Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanin via capsules and green tea. J Nutr. 2012;142(12):2091-2096. View abstract.
Sugiyama T, Sadzuda Y. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma. Cancer Lett 1998;133:19-26. View abstract.
Sugiyama T, Sadzuka Y, Tanaka K, Sonobe T. Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicol Lett 2000:121:89-96. View abstract.
Sugiyama T, Sadzuka Y. Combination of theanine with doxorobucin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin Cancer Res 1999;5:413-6. View abstract.
Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. View abstract.
Unno K, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary a-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav. 2013;111:128-135. View abstract.
Williams J, Kellett J, Roach PD, et al. L-theanine as a functional food additive: its role in disease prevention and health promotion. Beverages 2016;2(2):13.
Williams J, McKune AJ, Georgousopoulou EN, et al. The effect of L-theanine incorporated in a functional food product (mango sorbet) on physiological responses in healthy males: a pilot randomised controlled trial. Foods 2020;9(3):371. View abstract.
Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8. View abstract.
Yokogoshi H, Mochizuki M, Saitoh K. Theanine-induced reduction of brain serotonin concentration in rats. Biosci Biotechnol Biochem 1998;62:816-7. View abstract.
Yokozawa T, Dong E. Influence of green tea and its three major components upon low-density lipoprotein oxidation. Exp Toxicol Pathol 1997;49:329-35. View abstract.
Yokozawa T, Oura H, Nakagawa H, et al. Effects of a component of green tea on the proliferation of vascular smooth muscle cells. Biosci Biotechnol Biochem 1995;59:2134-6. View abstract.
Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012;31:28. View abstract.
Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 2004;18:55-62. View abstract.