SULFORAPHANE

OTHER NAME(S):

Glucosinolate de Sulforaphane, SFN, Sulforafane, Sulforaphane Glucosinolate, Sulforofano, Sulphoraphane, 1-isothiocayanate-4-methyl-sulfonyl butane.<br/><br/>

Overview

Overview Information

Sulforaphane is a chemical found in certain kinds of vegetables such as broccoli, cabbage, and cauliflower.

Sulforaphane is used for the prevention of prostate cancer and other types of cancer.

How does it work?

Sulforaphane may increase the death of cancer cells.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Asthma. Early research shows that taking sulforaphane does not improve lung function in people with asthma. However, it might protect against symptoms of lung squeezing in response to an airborne trigger in some people.
  • Autism. Early research in children and young adults with autism shows that taking sulforaphane might modestly improve behavior and social skills.
  • Chronic obstructive pulmonary disease (COPD). Early research shows that taking sulforaphane does not improve symptoms of COPD.
  • Allergy symptoms.
  • Preventing cancer.
  • Sunburn.
  • Other conditions.
More evidence is needed to rate the effectiveness of sulforaphane for these uses.

Side Effects

Side Effects & Safety

Sulforaphane is safe when used in the amounts found in foods. But there isn't enough information available to know if it is safe to take by mouth as a medicine.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Sulforaphane is safe in amounts found in food, but there's not enough information to know if it's safe in the larger amounts that are used as medicine.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SULFORAPHANE

    Some medications are changed and broken down by the liver.<br /> Sulforaphane might decrease how quickly the liver breaks down some medications. Taking sulforaphane along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking sulforaphane talk to your healthcare provider if you take any medications that are changed by the liver.<br /> Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Dosing

Dosing

The appropriate dose of sulforaphane depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sulforaphane. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. View abstract.
  • ASCEND Study Collaborative Group, Bowman L, Mafham M, et al. Effects of n-3 Fatty Acid Supplements in Diabetes Mellitus. N Engl J Med. 2018 Oct 18;379(16):1540-1550. View abstract.
  • Atwell LL, Zhang Z, Mori M, et al. Sulforaphane bioavailability and chemopreventive activity in women scheduled for breast biopsy. Cancer Prev Res (Phila). 2015;8(12):1184-91. View abstract.
  • Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. View abstract.
  • Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. View abstract.
  • Bose C, Awasthi S, Sharma R, et al. Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PLoS One. 2018;13(3):e0193918. View abstract.
  • Brooks JD, Paton V. Potent induction of carcinogen defense enzymes with sulforaphane, a putative prostate cancer chemopreventive agent. Prostate Cancer Prostatic Dis 1999;2:S8.. View abstract.
  • Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW. Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways. Respir Res. 2015;16:106. View abstract.
  • Chiao JW, Chung FL, Kancherla R, et al. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol 2002;20:631-6.. View abstract.
  • Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. View abstract.
  • Conaway CC, Getahun SM, Liebes LL, et al. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer 2000;38:168-78.. View abstract.
  • Doss JF, Jonassaint JC, Garrett ME, Ashley-Koch AE, Telen MJ, Chi JT. Phase 1 study of a sulforaphane-containing broccoli sprout homogenate for sickle cell disease. PLoS One. 2016;11(4):e0152895. View abstract.
  • Elkashty OA, Ashry R, Elghanam GA, et al. Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas. Med Oncol. 2018;35(9):124. View abstract.
  • Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). View abstract.
  • Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. View abstract.
  • Heiss E, Herhaus C, Klimo K, et al. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 2001;276:32008-15. View abstract.
  • Hintze KJ, Keck AS, Finley JW, Jeffery EH. Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats. J Nutr Biochem 2003;14:173-9. View abstract.
  • Nestle M. Broccoli sprouts in cancer prevention. Nutr Rev 1998;56:127-30.. View abstract.
  • Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. View abstract.
  • Rutz J, Juengel E, Euler S, et al. Chronic sulforaphane application does not induce resistance in renal cell carcinoma cells. Anticancer Res. 2018;38(11):6201-6207. View abstract.
  • Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. View abstract.
  • Vermeulen M, van Rooijen HJ, Vaes WH. Analysis of isothiocyanate mercapturic acids in urine: a biomarker for cruciferous vegetable intake. J Agric Food Chem 2003;51:3554-9.. View abstract.
  • Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. View abstract.
  • Wu L, Noyan Ashraf MH, Facci M, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci U S A 2004;101:7094-9. View abstract.
  • Zhang J, Svehlikova V, Bao Y, et al. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 2003;24:497-503.. View abstract.
  • Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J 2002;364:301-7.. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.