BLACKBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Blackberry is a plant. The leaf, root, and fruit (berry) are used to make medicine.

Blackberry is used for diarrhea, fluid retention, diabetes, gout, pain and swelling (inflammation), throat irritation, and other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

Blackberry contains chemicals that might have antioxidant effects. It also contains chemicals that might protect against cancer.

Uses & Effectiveness ?

Insufficient Evidence for

Fluid retention.
Diabetes.
Diarrhea.
Gout.
Pain and swelling (inflammation).
Cancer.
Heart disease.
Other conditions.

More evidence is needed to rate the effectiveness of blackberry for these uses.

Side Effects

When taken by mouth: Blackberry fruit is LIKELY SAFE in the amounts commonly found in food. There isn't enough reliable information to know if blackberry is safe in the larger amounts used as medicine or what the side effects might be.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if blackberry is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Interactions ?

We currently have no information for BLACKBERRY overview.

Dosing

The appropriate dose of blackberry for use as treatment depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for blackberry. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

Blomhoff, R. [Antioxidants and oxidative stress]. Tidsskr.Nor Laegeforen. 6-17-2004;124(12):1643-1645. View abstract.

Carmen Ramirez-Tortosa, M., Garcia-Alonso, J., Luisa Vidal-Guevara, M., Quiles, J. L., Jesus, Periago M., Linde, J., Dolores, Mesa M., Ros, G., Abellan, P., and Gil, A. Oxidative stress status in an institutionalised elderly group after the intake of a phenolic-rich dessert. Br J Nutr 2004;91(6):943-950. View abstract.

Halvorsen, B. L., Holte, K., Myhrstad, M. C., Barikmo, I., Hvattum, E., Remberg, S. F., Wold, A. B., Haffner, K., Baugerod, H., Andersen, L. F., Moskaug, O., Jacobs, D. R., Jr., and Blomhoff, R. A systematic screening of total antioxidants in dietary plants. J Nutr 2002;132(3):461-471. View abstract.

Netzel, M., Strass, G., Janssen, M., Bitsch, I., and Bitsch, R. Bioactive anthocyanins detected in human urine after ingestion of blackcurrant juice. J Environ.Pathol Toxicol Oncol 2001;20(2):89-95. View abstract.

Pellegrini, N., Serafini, M., Colombi, B., Del Rio, D., Salvatore, S., Bianchi, M., and Brighenti, F. Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J Nutr 2003;133(9):2812-2819. View abstract.

Alonso R, Cadavid I, Calleja JM. A preliminary study of hypoglycemic activity of Rubus fruticosus. Planta Med 1980;Suppl:102-6.. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182

Feng R, Bowman LL, Lu Y, et al. Blackberry extracts inhibit activating protein 1 activation and cell transformation by perturbing the mitogenic signaling pathway. Nutr Cancer 2004;50:80-9. . View abstract.

Fernández-Demeneghi R, Rodríguez-Landa JF, Guzmán-Gerónimo RI, et al. Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats. Int J Food Sci Nutr 2019;70(7):856-67. View abstract.

Gowd V, Bao T, Wang L, et al. Antioxidant and antidiabetic activity of blackberry after gastrointestinal digestion and human gut microbiota fermentation. Food Chem. 2018 Dec 15;269:618-627. View abstract.

Ivanovska N, Philipov S. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol 1996;18:553-61. View abstract.

Miller CS, Danaher RJ, Kirakodu S, Carlson CR, Mumper RJ. Effect of chewing gum containing Xylitol and blackberry powder on oral bacteria: A randomized controlled crossover trial. Arch Oral Biol. 2022 Nov;143:105523. doi: 10.1016/j.archoralbio.2022.105523. View abstract.

Mirazi N, Hosseini A. Attenuating properties of Rubus fruticosus L. on oxidative damage and inflammatory response following streptozotocin-induced diabetes in the male Wistar rats. J Diabetes Metab Disord 2020;19(2):1311-1316. View abstract.

Rossi A, Serraino I, Dugo P, et al. Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation. Free Radic Res 2003;37:891-900.. View abstract.

Sauebin L, Rossi A, Serraino I, et al. Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Planta Med 2004;70:745-52. . View abstract.

Serraino I, Dugo L, Dugo P, et al. Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sci 2003;73:1097-114.. View abstract.

Siriwoharn T, Wrolstad RE, Finn CE, Pereira CB. Et al. Influence of cultivar, maturity, and sampling on blackberry (Rubus L. Hybrids) anthocyanins, polyphenolics, and antioxidant properties. J Agric Food Chem 2004;52:8021-30. . View abstract.

Solverson PM, Rumpler WV, Leger JL, et al. Blackberry Feeding Increases Fat Oxidation and Improves Insulin Sensitivity in Overweight and Obese Males. Nutrients. 2018 Aug 9;10(8). pii: E1048. View abstract.

Spínola V, Pinto J, Llorent-Martínez EJ, Tomás H, Castilho PC. Evaluation of Rubus grandifolius L. (wild blackberries) activities targeting management of type-2 diabetes and obesity using in vitro models. Food Chem Toxicol. 2019 Jan;123:443-452. View abstract.

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Wang SY, Jiao H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem 2000;48:5677-84.. View abstract.

Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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BLACKBERRY - Uses, Side Effects, and More