People use threonine for conditions such as a muscle control disorder marked by involuntary movements and muscle tightness (spasticity), multiple sclerosis (MS), inherited disorders marked by weakness and stiffness in the legs (familial spastic paraparesis or FSP), and Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS), but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness
Possibly Ineffective for
- Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS). Taking 2 grams to 4 grams of threonine daily for up to 12 months does not seem to slow the progression of ALS or reduce symptoms. There is also some evidence that threonine might actually worsen lung function in people with ALS.
Insufficient Evidence for
- Inherited disorders marked by weakness and stiffness in the legs (familial spastic paraparesis or FSP). Early research suggests that taking 1.5 grams to 2 grams of threonine by mouth three times daily might improve some symptoms in people with familial spastic paraparesis. But the improvement does not seem to be very significant.
- Multiple sclerosis (MS). Early research suggests that taking 2.5 grams of threonine by mouth three times daily for 8 weeks does not reduce muscle stiffness (spasticity) in people with MS.
- A muscle control disorder marked by involuntary movements and muscle tightness (spasticity). Early research suggests that taking 2 grams of threonine by mouth three times daily modestly decreases muscle contractions in people with spinal spasticity caused by spinal cord injury.
- Other conditions.
Special Precautions and Warnings
Amyotrophic lateral sclerosis (Lou Gehrig's disease):There is some concern that threonine might decrease lung function in patients with ALS. In one study, ALS patients taking 1 gram of threonine four times per day for 6 months had significantly reduced lung function compared to patients who did not receive threonine. More evidence is needed to determine if threonine was actually at fault.
Medications for Alzheimer disease (NMDA antagonists) interacts with THREONINE
There is some concern that threonine might decrease how well a medication used for Alzheimer's disease works. This medication is called memantine (Namenda).
Do not take this combination
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
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© Therapeutic Research Faculty 2020.