Acide Orthosilicique, Atomic number 14, Dioxyde de Silicium, Numéro Atomique 14, Orthosilicic Acid, Phytolithic Silica, Polysilicone-11, Si, Silica, Silica Hydride, Silice Hydride, Silicea, Silicio, Silicium, Silicium de Sodium, Silicon Dioxide, Sodium Silicate.
Overview InformationSilicon is a naturally occurring mineral. Many foods including water, beer, coffee, and some vegetables naturally contain silicon. Silicon supplements are also used as medicine.
Some people take silicon by mouth for weak bones (osteoporosis), heart disease and stroke (cardiovascular disease), Alzheimer's disease, hair loss, and improving hair and nail quality. It is also used for skin healing and for treating sprains and strains, as well as digestive system disorders.
Do not confuse silicon with silicone. Silicone is the name of a group of materials resembling plastic that contain silicon, oxygen, and other chemicals. Silicone is used to make breast implants, medical tubing, and a variety of other medical devices.
How does it work?A clear function of silicon in humans has not been established. There is some evidence, though, that silicon might have a role in bone and collagen formation.
Uses & Effectiveness
Possibly Effective for
- Increasing bone strength when obtained from foods. Men and younger (pre-menopausal) women who get more silicon from their diet seem to have stronger bones, which could reduce the risk of weak bones (osteoporosis). But higher silicon intake does not seem to benefit older (post-menopausal) women unless. These women tend to develop weak bones because their bodies continually break down bone. Silicon doesn't seem to stop the bone breakdown. It promotes only bone formation.
Insufficient Evidence for
- Alzheimer's disease.
- Digestion problems.
- Hair loss.
- Heart disease.
- Sprains and strain.
- Other conditions.
Side Effects & SafetySilicon is LIKELY SAFE in food amounts. Its safety as a medicine is unknown.
Special Precautions & Warnings:Pregnancy and breast-feeding: Silicon is LIKELY SAFE when used in food amounts. Its safety in larger medicinal amounts is unknown. Stay on the safe side and avoid use.
Surgical removal of the stomach (gastrectomy): Silicon values may be lower in patients who have had their stomachs surgically removed.
We currently have no information for SILICON Interactions.
The following doses have been studied in scientific research:
- For osteoporosis: Eating a diet that includes 40 mg of silicon seems to be linked with stronger bones than lower doses.
- Barel, A., Calomme, M., Timchenko, A., De, Paepe K., Demeester, N., Rogiers, V., Clarys, P., and Vanden Berghe, D. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol.Res 2005;297(4):147-153. View abstract.
- Belles, M., Sanchez, D. J., Gomez, M., Corbella, J., and Domingo, J. L. Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease. Alzheimer Dis.Assoc Disord. 1998;12(2):83-87. View abstract.
- Birchall, J. D. The interrelationship between silicon and aluminium in the biological effects of aluminium. Ciba Found.Symp. 1992;169:50-61. View abstract.
- Carlisle, E. M. A silicon requirement for normal skull formation in chicks. J Nutr 1980;110(2):352-359. View abstract.
- Carlisle, E. M. and Curran, M. J. Effect of dietary silicon and aluminum on silicon and aluminum levels in rat brain. Alzheimer Dis.Assoc Disord. 1987;1(2):83-89. View abstract.
- Carlisle, E. M. Biochemical and morphological changes associated with long bone abnormalities in silicon deficiency. J Nutr 1980;110(5):1046-1056. View abstract.
- Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204. View abstract.
- Dobbie, J. W. and Smith, M. B. Urinary and serum silicon in normal and uraemic individuals. Ciba Found.Symp. 1986;121:194-213. View abstract.
- Domingo, J. L. Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents. J Alzheimers.Dis. 2006;10(2-3):331-341. View abstract.
- Domingo, J. L., Gomez, M., and Colomina, M. T. Oral silicon supplementation: an effective therapy for preventing oral aluminum absorption and retention in mammals. Nutr Rev 2011;69(1):41-51. View abstract.
- Drueke, T. B., Jouhanneau, P., Banide, H., Lacour, B., Yiou, F., and Raisbeck, G. Effects of silicon, citrate and the fasting state on the intestinal absorption of aluminium in rats. Clin Sci (Lond) 1997;92(1):63-67. View abstract.
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- Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. View abstract.
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- Macdonald HM, Hardcastle AE, Jugdaohsingh R, Reid DM, and Powell JJ. Dietary silicon intake is associated with bone mineral density in premenopasual women and postmenopausal women taking HRT. Journal of Bone Mineral Research 2005;20:S393.
- Martin, K. R. The chemistry of silica and its potential health benefits. J Nutr Health Aging 2007;11(2):94-97. View abstract.
- McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. View abstract.
- McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. View abstract.
- Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. View abstract.
- Mock, T., Samanta, M. P., Iverson, V., Berthiaume, C., Robison, M., Holtermann, K., Durkin, C., Bondurant, S. S., Richmond, K., Rodesch, M., Kallas, T., Huttlin, E. L., Cerrina, F., Sussman, M. R., and Armbrust, E. V. Whole-genome expression profiling of the marine diatom Thalassiosira pseudonana identifies genes involved in silicon bioprocesses. Proc.Natl.Acad.Sci U.S.A 2-5-2008;105(5):1579-1584. View abstract.
- Nielsen, F. H. How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr 1996;126(9 Suppl):2377S-2385S. View abstract.
- Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. View abstract.
- Popplewell, J. F., King, S. J., Day, J. P., Ackrill, P., Fifield, L. K., Cresswell, R. G., di Tada, M. L., and Liu, K. Kinetics of uptake and elimination of silicic acid by a human subject: a novel application of 32Si and accelerator mass spectrometry. J Inorg.Biochem. 2-15-1998;69(3):177-180. View abstract.
- Reffitt, D. M., Jugdaohsingh, R., Thompson, R. P., and Powell, J. J. Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. J Inorg.Biochem. 8-30-1999;76(2):141-147. View abstract.
- Rondeau, V. A review of epidemiologic studies on aluminum and silica in relation to Alzheimer's disease and associated disorders. Rev Environ Health 2002;17(2):107-121. View abstract.
- Rondeau, V., Jacqmin-Gadda, H., Commenges, D., Helmer, C., and Dartigues, J. F. Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. Am J Epidemiol. 2-15-2009;169(4):489-496. View abstract.
- Scheinfeld, N., Dahdah, M. J., and Scher, R. Vitamins and minerals: their role in nail health and disease. J Drugs Dermatol. 2007;6(8):782-787. View abstract.
- Schiano, A., Eisinger, F., Detolle, P., Laponche, A. M., Brisou, B., and Eisinger, J. [Silicon, bone tissue and immunity]. Rev Rhum.Mal Osteoartic. 1979;46(7-9):483-486. View abstract.
- Semple, J. L. Breast-feeding and silicone implants. Plast Reconstr Surg 2007;120(7 Suppl 1):123S-128S. View abstract.
- Soyseth, V., Johnsen, H. L., Benth, J. S., Hetland, S. M., and Kongerud, J. Production of silicon metal and alloys is associated with accelerated decline in lung function: a 5-year prospective study among 3924 employees in norwegian smelters. J Occup.Environ Med 2007;49(9):1020-1026. View abstract.
- Spector TD, Calomme MR, Anderson S, Swaminathan R, Jugdaohsingh R, Vanden-Berge DA, and Powell JJ. Effect of bone turnover and BMD of low dose oral silicon as an adjunct to calcium/vitamin D3 in a randomized placebo-controlled trial. Journal of Bone Mineral Research 2005;20:S172.
- Sripanyakorn, S., Jugdaohsingh, R., Dissayabutr, W., Anderson, S. H., Thompson, R. P., and Powell, J. J. The comparative absorption of silicon from different foods and food supplements. Br J Nutr 2009;102(6):825-834. View abstract.
- Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. View abstract.
- Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. View abstract.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
- Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. View abstract.
- Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. 13, Arsenic, Boron, Nickel, Silicon, and Vanadium. https://www.ncbi.nlm.nih.gov/books/NBK222322/. Accessed September 29, 2017.
- Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. View abstract.
- Jugdaohsingh R, Tucker KL, Qiao N, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res 2004;19:297-307. View abstract.
- Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. View abstract.
- Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5.
- Li Z, Karp H, Zerlin A, Lee TY, Carpenter C, Heber D. Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study. Nutr J. 2010;9:44. View abstract.
- Marcowycz A, Housez B, Maudet C, Cazaubiel M, Rinaldi G, Croizet K. Digestive absorption of silicon, supplemented as orthosilicic acid-vanillin complex. Mol Nutr Food Res. 2015;59(8):1584-9. View abstract.
- Rico H, Gallego-Lago JL, Hernandez ER, et al. Effect of silicon supplement on osteopenia induced by ovariectomy in rats. Calcif Tissue Int 2000;66:53-5. View abstract.
- Tatara MR, Krupski W, Szpetnar M, Dabrowski A, Bury P, Szabelska A, et al. Effects of total gastrectomy on plasma silicon and amino acid concentrations in men. Abstract. Exp Biol Med (Maywood). 2015;240(12):1557-63. View abstract.
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